Catalog No.
YHJ08101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe103
Predicted molecular weight
38.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6UUV7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CRTC3, Transducer of regulated cAMP response element-binding protein 3, Transducer of CREB protein 3, TORC3, TORC-3, CREB-regulated transcription coactivator 3
Dietary advanced glycation end-products exacerbate sarcopenia onset by activating apoptosis through PRMT1-mediated CRTC3 arginine methylation., PMID:40192801
Genomic and Transcriptomic Profiling of Digital Papillary Adenocarcinomas Reveals Alterations in Matrix Remodeling and Metabolic Genes., PMID:39757862
CRTC3 restricts SARS-CoV-2 replication and is antagonized by CREB., PMID:39736320
Regulation of Sleep Amount by CRTC1 via Transcription of Crh in Mice., PMID:39622645
Long read sequencing identifies complex structural variant landscape and recurrent TERT rearrangements in mucoepidermoid carcinoma., PMID:39549430
Comprehensive mutational profiling identifies new driver events in cutaneous leiomyosarcoma., PMID:39392932
Semaxanib, a VEGF inhibitor, suppresses melanogenesis by modulating CRTC3 independently of VEGF signaling., PMID:39127591
Low-grade carcinoma with acinic cell carcinoma-like features of the parotid gland with CRTC3::IQGAP1 fusion., PMID:38563588
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation., PMID:38147543
Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse., PMID:37730843
In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma., PMID:37666810
Genetic and Immunohistochemical Profiling of Mammary Hidradenoma and Comparison to Mucoepidermoid Carcinoma., PMID:37422157
Discovery of pyrimidine-5-carboxamide derivatives as novel salt-inducible kinases (SIKs) inhibitors for inflammatory bowel disease (IBD) treatment., PMID:37178481
Stress signaling boosts interferon-induced gene transcription in macrophages., PMID:36512641
Mucoepidermoid carcinoma may be devoid of squamoid cells by immunohistochemistry: expanding the histologic and immunohistochemical spectrum of MAML2- rearranged salivary gland tumours., PMID:36208053
CRTC3, a sensor and key regulator for melanogenesis, as a tunable therapeutic target for pigmentary disorders., PMID:34815795
Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB/MITF pathway in melanocytes and ex vivo human skin., PMID:34803425
[MAML2 gene rearrangement, fusion patterns and clinicopathological characteristics in primary pulmonary mucoepidermoid carcinoma]., PMID:34344072
Mucoepidermoid carcinoma of the salivary glands revisited with special reference to histologic grading and CRTC1/3-MAML2 genotyping., PMID:34231055
Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling., PMID:34196217
Targeted RNA sequencing in the routine clinical detection of fusion genes in salivary gland tumors., PMID:34176176
CRTC3 Regulates the Lipid Metabolism and Adipogenic Differentiation of Porcine Intramuscular and Subcutaneous Adipocytes by Activating the Calcium Pathway., PMID:34142819
Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways., PMID:34010639
HG-9-91-01 Attenuates Murine Experimental Colitis by Promoting Interleukin-10 Production in Colonic Macrophages Through the SIK/CRTC3 Pathway., PMID:33988718
Morphological and biological properties of silica nanoparticles for CRTC3-siRNA delivery and downregulation of the RGS2 expression in preadipocytes., PMID:33947275
SalvGlandDx - a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets., PMID:33878706
TORC2/3-mediated DUSP1 upregulation is essential for human decidualization., PMID:33780908
Dasatinib Stimulates Its Own Mechanism of Resistance by Activating a CRTC3/MITF/Bcl-2 Pathway in Melanoma with Mutant or Amplified c-Kit., PMID:33741716
The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA Pol II from Binding to HIV-1 LTR., PMID:33723808
Comprehensive evaluation of the metabolic effects of porcine CRTC3 overexpression on subcutaneous adipocytes with metabolomic and transcriptomic analyses., PMID:33653408
Genetic Factors in Antiphospholipid Syndrome: Preliminary Experience with Whole Exome Sequencing., PMID:33333988
Activation and expression of endogenous CREB-regulated transcription coactivators (CRTC) 1, 2 and 3 in the rat adrenal gland., PMID:33314405
Prognostic impact of CRTC1/3-MAML2 fusions in salivary gland mucoepidermoid carcinoma: A multiinstitutional retrospective study., PMID:32860299
Lung Cancer Occurrence-Correlation with Serum Chromium Levels and Genotypes., PMID:32648197
Breed difference and regulatory role of CRTC3 in porcine intramuscular adipocyte., PMID:32400010
JNK suppresses melanogenesis by interfering with CREB-regulated transcription coactivator 3-dependent MITF expression., PMID:32226536
Clinicopathological significance of EGFR pathway gene mutations and CRTC1/3-MAML2 fusions in salivary gland mucoepidermoid carcinoma., PMID:32129900
An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders., PMID:32092816
Involvement of CREB-regulated transcription coactivators (CRTC) in transcriptional activation of steroidogenic acute regulatory protein (Star) by ACTH., PMID:31604124
Therapeutic Potential of Rottlerin for Skin Hyperpigmentary Disorders by Inhibiting the Transcriptional Activity of CREB-Regulated Transcription Coactivators., PMID:31176710
Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment., PMID:30611118
Genetic variants and haplotype combination in the bovine CRTC3 affected conformation traits in two Chinese native cattle breeds (Bos Taurus)., PMID:30529539
Cold exposure induces nuclear translocation of CRTC3 in brown adipose tissue., PMID:30506739
Parathyroid hormone(1-34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling., PMID:30377251
"Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid Carcinoma of the Salivary Gland, and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma With Mucoepidermoid Carcinoma-like Features., PMID:30138216
Cyclic adenosine monophosphate-regulated transcriptional co-activator 3 polymorphism in Chinese patients with acute coronary syndrome., PMID:29979427
Rapid Communication: Porcine CRTC3 gene clone, expression pattern, and its regulatory role in intestinal epithelial cells., PMID:29796654
cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis., PMID:29784793
Dual Role of CREB in The Regulation of VSMC Proliferation: Mode of Activation Determines Pro- or Anti-Mitogenic Function., PMID:29559698
NEDD4L limits cAMP signaling through ubiquitination of CREB-regulated transcription coactivator 3., PMID:29505301
For research use only. Not for human or drug use.
