Catalog No.
YHJ03301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Trp34-Arg300
Predicted molecular weight
33.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5TCY1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA1855, TTBK1, Brain-derived tau kinase, Tau-tubulin kinase 1, BDTK
Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration., PMID:40340943
Environmental enrichment attenuates sevoflurane anesthesia-induced learning deficits in aged mice through regulating TTBK1 and phosphorylated Tau expression., PMID:39953251
Enriched environment mitigates cognitive impairment in pre-adolescent mice following repeated neonatal sevoflurane exposure by reducing TTBK1 expression and Tau phosphorylation., PMID:39892471
Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond., PMID:39638711
Computational Design of Novel Tau-Tubulin Kinase 1 Inhibitors for Neurodegenerative Diseases., PMID:39065802
Computational identification of potential tau tubulin kinase 1 (TTBK1) inhibitors: a structural analog approach., PMID:39050776
CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation., PMID:38677657
Liraglutide versus pramlintide in protecting against cognitive function impairment through affecting PI3K/AKT/GSK-3β/TTBK1 pathway and decreasing Tau hyperphosphorylation in high-fat diet- streptozocin rat model., PMID:38536493
Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice., PMID:37853497
Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells-derived neural rosettes., PMID:37558899
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library., PMID:37399991
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis., PMID:37059819
Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation., PMID:36538853
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy., PMID:34978799
Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology., PMID:34752923
Characterizing the role of Tupaia DNA damage inducible transcript 3 (DDIT3) gene in viral infections., PMID:34748795
CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1., PMID:34726688
The structural, functional, and dynamic effect of Tau tubulin kinase1 upon a mutation: A neuro-degenerative hotspot., PMID:34297427
Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo., PMID:33944571
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice., PMID:33228809
Long non-coding RNA 00507/miRNA-181c-5p/TTBK1/MAPT axis regulates tau hyperphosphorylation in Alzheimer's disease., PMID:32891070
Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms., PMID:32424773
Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites., PMID:32255788
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor., PMID:32133995
Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models., PMID:32019603
Tau tubulin kinases in proteinopathy., PMID:31034749
Identification of human tau-tubulin kinase 1 inhibitors: an integrated e-pharmacophore-based virtual screening and molecular dynamics simulation., PMID:30829560
miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β in Alzheimer's disease., PMID:30556160
Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases., PMID:30342424
Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration., PMID:29409526
Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock., PMID:28886336
Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau., PMID:28711868
Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by Aβ1-42., PMID:28018474
De novo variants in sporadic cases of childhood onset schizophrenia., PMID:26508570
Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1., PMID:25673844
The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43., PMID:25473830
Tau-tubulin kinase., PMID:24808823
The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor., PMID:24637750
Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1., PMID:24418258
X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitors., PMID:24039150
Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain., PMID:23088643
Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese., PMID:21219968
Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice., PMID:20354135
Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases., PMID:20158871
Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort., PMID:20096481
[Bioinformatic search of plant protein kinases, participating in microtubule protein phosphorylation and cell division regulation]., PMID:19938639
The microtubule-associated protein tau is also phosphorylated on tyrosine., PMID:19542604
Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1., PMID:19118186
Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation., PMID:16923168
For research use only. Not for human or drug use.
