Catalog No.
YHJ01801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu544-Ser806
Predicted molecular weight
31.74 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5JRX3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pitrilysin metalloproteinase 1, hMP1, MP1, Metalloprotease 1, PREP, KIAA1104, Presequence protease, mitochondrial, PITRM1, hPreP
Exploiting Mitochondria by Triggering a Faulty Unfolded Protein Response Leads to Effective Cardioprotection., PMID:39744160
Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity., PMID:38906862
PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients., PMID:37576821
In silico exploration of antioxidants as oxidation protectant for PITRM1 peptidase activity, an Alzheimer disease target., PMID:37218421
Exploring Whether Iron Sequestration within the CNS of Patients with Alzheimer's Disease Causes a Functional Iron Deficiency That Advances Neurodegeneration., PMID:36979320
Functional genomics analysis reveals the evolutionary adaptation and demographic history of pygmy lorises., PMID:36161902
PITRM1 interaction studies with amyloidogenic nonapeptide mutants of familial Alzheimer's disease., PMID:35751131
DELE1 tracks perturbed protein import and processing in human mitochondria., PMID:35388015
Role of PITRM1 in Mitochondrial Dysfunction and Neurodegeneration., PMID:34356897
Gain of PITRM1 peptidase in cortical neurons affords protection of mitochondrial and synaptic function in an advanced age mouse model of Alzheimer's disease., PMID:33951271
In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration., PMID:33835239
Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation., PMID:32857715
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids., PMID:32632204
Functional coupling of presequence processing and degradation in human mitochondria., PMID:32491259
Mitochondrial PITRM1 peptidase loss-of-function in childhood cerebellar atrophy., PMID:29764912
Systematic analysis reveals long noncoding RNAs regulating neighboring transcription factors in human cancers., PMID:29753811
Functional requirement for human pitrilysin metallopeptidase 1 arginine 183, mutated in amyloidogenic neuropathy., PMID:29383861
An Exome-Wide Association Study Identifies New Susceptibility Loci for Age of Smoking Initiation in African- and European-American Populations., PMID:29216386
Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin., PMID:29183787
Amyloid-β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing., PMID:26813924
Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration., PMID:26697887
Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin., PMID:26671574
Identification of putative SNPs in progressive retinal atrophy affected Canis lupus familiaris using exome sequencing., PMID:26515695
Genetic and biochemical studies of SNPs of the mitochondrial A beta-degrading protease, hPreP., PMID:19962426
The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors., PMID:19877269
Association of gene polymorphisms with chronic kidney disease in Japanese individuals., PMID:19724895
Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases., PMID:10360838
For research use only. Not for human or drug use.
