Catalog No.
YHH98801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu1222-Gln1368
Predicted molecular weight
18.47 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5D862
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Intermediate filament-associated and psoriasis-susceptibility protein, Filaggrin-2, FLG2, Ifapsoriasin, IFPS, FLG-2
ART26.12, an FABP5 Inhibitor, Shows Efficacy in Preclinical Psoriasis Models., PMID:40210114
Filaggrinopathies-FLG/FLG2: Diagnostic Complexities and Immunotherapy., PMID:39927906
Effect of tumour necrotic factor-α, interleukin-17 and interleukin-22 on the expression of filaggerin-2 and hornerin: Analysis of a three-dimensional psoriatic skin model., PMID:39624730
Recombinant filaggrin-2 improves skin barrier function and attenuates ultraviolet B (UVB) irradiation-induced epidermal barrier disruption., PMID:39341309
Dermal Injection of Recombinant Filaggrin-2 Ameliorates UVB-Induced Epidermal Barrier Dysfunction and Photoaging., PMID:39199247
Integrative multi-omics analysis unravels the host response landscape and reveals a serum protein panel for early prognosis prediction for ARDS., PMID:38956604
Comparative genomics of sirenians reveals evolution of filaggrin and caspase-14 upon adaptation of the epidermis to aquatic life., PMID:38653760
Comparative genomics of monotremes provides insights into the early evolution of mammalian epidermal differentiation genes., PMID:38228724
Altered expression of S100 fused-type proteins in an atopic dermatitis skin model., PMID:36995036
Scleral Proteome in Noninfectious Scleritis Unravels Upregulation of Filaggrin-2 and Signs of Neovascularization., PMID:36930145
Integrated Whole-Exome and Transcriptome Sequencing Indicated Dysregulation of Cholesterol Metabolism in Eyelid Sebaceous Gland Carcinoma., PMID:36735267
Gene Expression Linked to Reepithelialization of Human Skin Wounds., PMID:36555389
Delayed type hypersensitivity reactions to various allergens may differently model inflammatory skin diseases., PMID:36178084
Robust prognostic model based on immune infiltration-related genes and clinical information in ovarian cancer., PMID:35735060
Penehyclidine hydrochloride suppresses inflammation response and reduces podocyte injury in diabetic nephropathy by targeting fibrinogen-like protein 2., PMID:35303505
Uncommon variants in FLG2 and TCHHL1 are associated with remission of atopic dermatitis in a large longitudinal US cohort., PMID:34984527
Expression levels of filaggrin-2 in relation to drip loss in pigs., PMID:34696573
Dystrophic epidermolysis bullosa pruriginosa: a new case series of a rare phenotype unveils skewed Th2 immunity., PMID:34543471
Investigation of the role of IL18, IL-1β and NLRP3 inflammasome in reducing expression of FLG-2 protein in Psoriasis vulgaris skin lesions., PMID:34313166
N6-Methyladenosine-Related RNA Signature Predicting the Prognosis of Ovarian Cancer., PMID:34137363
MMP-3 plays a major role in calcium pantothenate-promoted wound healing after fractional ablative laser treatment., PMID:33990899
Targeted Sequencing of Pancreatic Adenocarcinomas from Patients with Metachronous Pulmonary Metastases., PMID:33255265
Sphingosine 1-Phosphate Receptor 2 Is Central to Maintaining Epidermal Barrier Homeostasis., PMID:33197483
Could cellular and signaling abnormalities converge to provoke atopic dermatitis?, PMID:33048449
Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis., PMID:32751111
Identification of candidate mediators of chemoresponse in breast cancer through therapy-driven selection of somatic variants., PMID:32734521
Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis., PMID:32709423
Tape strips from early-onset pediatric atopic dermatitis highlight disease abnormalities in nonlesional skin., PMID:32639640
Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation., PMID:32437351
Expression Profiles of Genes Encoding Cornified Envelope Proteins in Atopic Dermatitis and Cutaneous T-Cell Lymphomas., PMID:32213830
Analysis of filaggrin 2 gene polymorphisms in patients with atopic dermatitis., PMID:32151410
Skin barrier damage after exposure to paraphenylenediamine., PMID:31783056
Identification and functional characterization of two novel mutations in KCNJ10 and PI4KB in SeSAME syndrome without electrolyte imbalance., PMID:31640787
Clinical and in vitro evaluation of new anti-redness cosmetic products in subjects with winter xerosis and sensitive skin., PMID:31309600
EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis., PMID:31158401
Whole-exome sequencing indicates FLG2 variant associated with leg ulcers in Brazilian sickle cell anemia patients., PMID:31079484
Development of a platform for activatable fluorescent substrates of glucose transporters (GLUTs)., PMID:30935790
Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch., PMID:30851411
The Amino-Terminal Part of Human FLG2 Is a Component of Cornified Envelopes., PMID:30528829
The Effect of Adiponectin on the Regulation of Filaggrin Expression in Normal Human Epidermal Keratinocytes., PMID:33911503
Peeling Skin Disorders: A Paradigm for Skin Desquamation., PMID:30032785
Filaggrin 2 Deficiency Results in Abnormal Cell-Cell Adhesion in the Cornified Cell Layers and Causes Peeling Skin Syndrome Type A., PMID:29758285
Generalized Ichthyotic Peeling Skin Syndrome due to FLG2 Mutations., PMID:29505760
Expression and Regulation of S100 Fused-Type Protein Hornerin at the Ocular Surface and Lacrimal Apparatus., PMID:29183042
GATA3 regulates FLG and FLG2 expression in human primary keratinocytes., PMID:28928464
Peeling skin syndrome associated with novel variant in FLG2 gene., PMID:28884927
Molecular effects of fractional ablative erbium:YAG laser treatment with multiple stacked pulses on standardized human three-dimensional organotypic skin models., PMID:28299490
Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing., PMID:28068897
Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype., PMID:27304082
The expression profile of filaggrin-2 in the normal and pathologic human oral mucosa., PMID:26858109
For research use only. Not for human or drug use.
