Catalog No.
YHH89301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr15-Pro300
Predicted molecular weight
58.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q53H12
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MULK, Acylglycerol kinase, mitochondrial, hAGK, Multiple substrate lipid kinase, HsMuLK, MuLK, Multi-substrate lipid kinase, AGK
Oral iptacopan monotherapy in paroxysmal nocturnal haemoglobinuria: final 48-week results from the open-label, randomised, phase 3 APPLY-PNH trial in anti-C5-treated patients and the open-label, single-arm, phase 3 APPOINT-PNH trial in patients previously untreated with complement inhibitors., PMID:40447351
Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCδ and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-related neurodegenerative diseases., PMID:40313592
Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia., PMID:40279247
Computational Modeling of Effects of PKP2 Gene Therapy on Ventricular Conduction Properties in Arrhythmogenic Cardiomyopathy., PMID:40201954
MEK inhibitors for the treatment of immunotherapy-resistant, AGK-BRAF fusion advanced acral melanoma: a case report and literature review., PMID:40189647
Preclinical Activity of the Type II RAF Inhibitor Tovorafenib in Tumor Models Harboring Either a BRAF Fusion or an NF1 Loss-of-Function Mutation., PMID:40111124
Sengers syndrome caused by biallelic TIMM29 variants and RNAi silencing in Drosophila orthologue recapitulates the human phenotype., PMID:40022150
Novel c.221+1dup pathogenic variant in AGK gene linked to Sengers syndrome., PMID:39824030
Acylglycerol kinase inhibits macrophage anti-tumor activity via limiting mtDNA release and cGAS-STING-type I IFN response., PMID:39816692
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer., PMID:39814891
Aberrantly Expressed Mitochondrial Lipid Kinase, AGK, Activates JAK2-Histone H3 Axis and BCR Signal: A Mechanistic Study with Implication in CLL Therapy., PMID:39636206
Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking and Protein Degradation Mechanisms., PMID:39596274
Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson's and other related neurodegenerative diseases., PMID:39578912
Disease Activity in Pregnant and Postpartum Women With Multiple Sclerosis Receiving Ocrelizumab or Other Disease-Modifying Therapies., PMID:39442037
AGK2, a SIRT2 inhibitor, ameliorates D-galactose-induced liver fibrosis by inhibiting fibrogenic factors., PMID:39400930
Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer., PMID:39282910
The clinical relevance of MOG antibody testing in cerebrospinal fluid., PMID:39073255
Development and Progression of Polyneuropathy Over 5 Years in Patients With Type 2 Diabetes., PMID:39008800
High-Yield α-Synuclein Purification and Ionic Strength Modification Pivotal to Seed Amplification Assay Performance and Reproducibility., PMID:38892177
Multifocal Papillary Thyroid Carcinomas With Discordant Molecular Drivers: Emphasizing the Morphology and Collision Tumors., PMID:38818543
Manganese and Vanadium Co-Exposure Induces Severe Neurotoxicity in the Olfactory System: Relevance to Metal-Induced Parkinsonism., PMID:38791326
Developing a membrane-proximal CD33-targeting CAR T cell., PMID:38772686
GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit enhanced antitumor activity against hepatocellular carcinoma., PMID:38750075
Safety and Immunogenicity of Accelerated Heterologous 2-Dose Ebola Vaccine Regimens in Adults With and Without HIV in Africa., PMID:38657084
AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation., PMID:38643150
Pharmacokinetics, pharmacodynamics, efficacy, and safety of ravulizumab in pediatric paroxysmal nocturnal hemoglobinuria., PMID:38551806
Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Hemoglobinuria., PMID:38477987
The MOG antibody non-P42 epitope is predictive of a relapsing course in MOG antibody-associated disease., PMID:38290838
Rare AGK-BRAF gene fusion in an adolescent with supratentorial pleomorphic xanthoastrocytoma., PMID:38238163
A Systematic Review of Lipid-Focused Cardiovascular Disease Research: Trends and Opportunities., PMID:38132464
A novel somatostatin receptor ligand for human ACTH - and GH -secreting pituitary adenomas., PMID:38123488
Pharmacological inhibition of SIRT-2 by AK-7 modulates redox status and apoptosis via regulating Nrf2 in an experimental model of chronic obstructive pulmonary disease: an invivo and insilico study., PMID:38078439
Interaction of ROMK2 channel with lipid kinases DGKE and AGK: Potential channel activation by localized anionic lipid synthesis., PMID:38056763
Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling., PMID:38036617
Addition of danicopan to ravulizumab or eculizumab in patients with paroxysmal nocturnal haemoglobinuria and clinically significant extravascular haemolysis (ALPHA): a double-blind, randomised, phase 3 trial., PMID:38030318
SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer's Disease., PMID:37698780
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases., PMID:37684054
miR-3133 inhibits gastrointestinal cancer progression through activation of Hippo and p53 signalling pathways via multi-targets., PMID:37555915
The role of SIRT2 inhibition on the aging process of brain in male rats., PMID:37519449
Effectiveness of multiple disease-modifying therapies in relapsing-remitting multiple sclerosis: causal inference to emulate a multiarm randomised trial., PMID:37414534
Locus for severity implicates CNS resilience in progression of multiple sclerosis., PMID:37380766
Sengers syndrome and AGK-related disorders - Minireview of phenotypic variability and clinical outcomes in molecularly confirmed cases., PMID:37354892
Changing from preserved, to preservative-free cyclosporine 0.1% enhanced triple glaucoma therapy: impact on ocular surface disease-a randomized controlled trial., PMID:37221362
Probing differences among Aβ oligomers with two triangular trimers derived from Aβ., PMID:37216514
Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody., PMID:37202422
ZDHHC2-Mediated AGK Palmitoylation Activates AKT-mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma., PMID:37078777
AGK Potentiates Arterial Thrombosis by Affecting Talin-1 and αIIbβ3-Mediated Bidirectional Signaling Pathway., PMID:37051931
Adipose Insulin Resistance Associates With Dyslipidemia Independent of Liver Resistance and Involves Early Hormone Signaling., PMID:37051928
Microglial immune regulation by epigenetic reprogramming through histone H3K27 acetylation in neuroinflammation., PMID:37033967
LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma., PMID:37009826
For research use only. Not for human or drug use.
