Catalog No.
YHH50001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser21-Ala135
Predicted molecular weight
15.00 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q2MKA7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
R-spondin-1, hRspo1, RSPO1, Roof plate-specific spondin-1
Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby., PMID:40481762
From Spheroid to Sprouting: Microenvironmental Modulation Boosts Hair Follicle Organoid Morphogenesis in 3D Culture., PMID:40464526
Phylogenetic Insights into the Evolutionary History of the RSPO Gene Family in Metazoa., PMID:40428299
Transcriptomic Profiling of Hypoxia-Adaptive Responses in Tibetan Goat Fibroblasts., PMID:40427283
RSPO1, a potent inducer of pancreatic β cell neogenesis., PMID:40339569
FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development., PMID:40102860
Tumour protein p53-activated lncRNA PGM5-AS1 suppresses lung cancer growth and stemness by targeting R-spondin1 via microRNA-1247-5p., PMID:40035308
Air-liquid interface culture combined with differentiation factors reproducing intestinal cell structure formation in vitro., PMID:39832187
R-spondin1 plays an indispensable role in ovarian development of Qi River crucian carp (Carassius auratus) by regulating estrogen synthesis., PMID:39826263
Functional and Biological Characterization of the LGR5Δ5 Splice Variant in HEK293T Cells., PMID:39769183
Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling., PMID:39753551
Human artificial chromosome carrying R-spondin1 and IL-22 expression cassettes in rejuvenated MSCs enhances therapeutic efficacy in ulcerative colitis model mice., PMID:39693903
Comparative Analysis of Commercial and Home-Made Media on RSPO1/S6R Axis in Organoids with Different Wnt Backgrounds: A Methodological Guide for the Selection of Intestinal Patient-Derived Organoids Culture Media., PMID:39519079
Wnt specifically induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL., PMID:39463927
RSPO/LGR signaling regulates proliferation of adult hippocampal neural stem cells., PMID:39432578
Hormonally and chemically defined expansion conditions for organoids of biliary tree Stem Cells., PMID:39309110
QPH-FR: A Novel Quinoa Peptide Enhances Chemosensitivity by Targeting Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 in Colorectal Cancer., PMID:39047262
Signaling pathways associated with Lgr6 to regulate osteogenesis., PMID:39033993
Delta-like noncanonical notch ligand 2 regulates the proliferation and differentiation of sheep myoblasts through the Wnt/β-catenin signaling pathway., PMID:39030845
Enhancing precision in colorectal cancer surgery: development of an LGR5-targeting RSPO1 peptide mimetic as a contrast agent for intraoperative fluorescence molecular imaging., PMID:38984667
Identification and Validation of Immune Implication of R-Spondin 1 and an R-Spondin 1-Related Prognostic Signature in Esophagus Cancer., PMID:38962149
A Search for New Biological Pathways in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy by Proteomic Research., PMID:38892848
Inhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development., PMID:38879537
Prognostic prediction and diagnostic role of Rspondin 1 expression in esophageal squamous cell carcinoma., PMID:38864442
Roles of estrogen receptors during sexual reversal in Pelodiscus sinensis., PMID:38727746
Hepatic LGR4 aggravates cholestasis-induced liver injury in mice., PMID:38440827
Inefficient Sox9 upregulation and absence of Rspo1 repression lead to sex reversal in the B6.XYTIR mouse gonad†., PMID:38376238
R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis., PMID:38183076
R-Spondin1 protects gastric stem cells and mitigates gastric GVHD in allogeneic hematopoietic stem cell transplantation., PMID:38147622
Differentially expressed genes in orbital adipose/connective tissue of thyroid-associated orbitopathy., PMID:38130930
Single-Exon Deletions of ZNRF3 Exon 2 Cause Congenital Adrenal Hypoplasia., PMID:37878959
Drynaria Naringin alleviated mechanical stress deficiency-caused bone loss deterioration via Rspo1/Lgr4-mediated Wnt/β-catenin signalling pathway., PMID:37831321
Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos., PMID:37767857
Circ_0000396 suppresses the proliferation and inflammation of rheumatoid arthritis synovial fibroblasts by targeting miR-574-5p/RSPO1 axis., PMID:37737195
CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate., PMID:37726790
Spatiotemporal expression patterns of R-spondins and their receptors, Lgrs, in the developing mouse telencephalon., PMID:37651925
Sensitive Quantitative In Vivo Assay for Evaluating the Effects of Biomolecules on Hair Growth and Coloring Using Direct Microinjections into Mouse Whisker Follicles., PMID:37509112
Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway., PMID:37475547
Female-Biased Expression of R-spondin 1 in Chicken Embryonic Gonads Is Estrogen-Dependent., PMID:37444038
A novel reporter mouse line for studying alveolar macrophages., PMID:37428305
Association of muscular strength and targeted proteomics involved in brain health in children with overweight/obesity., PMID:37190796
Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice., PMID:37102205
Cerebrospinal fluid and serum proteomic profiles accurately distinguish neuroaxonal dystrophy from cervical vertebral compressive myelopathy in horses., PMID:36929645
Comparison of the Cost and Effect of Combined Conditioned Medium and Conventional Medium for Fallopian Tube Organoid Cultures., PMID:36919683
Rspo1 inhibited apoptosis of glucocorticoid-induced osteoblasts via Wnt/β-catenin pathway in Legg-Calve-Perthes disease., PMID:36881360
Exploiting the Receptor-Binding Domains of R-Spondin 1 to Target Leucine-Rich Repeat-Containin G-Coupled Protein Receptor 5-Expressing Stem Cells in Ovarian Cancer., PMID:36849411
RSPO3 Furin domain-conjugated liposomes for selective drug delivery to LGR5-high cells., PMID:36813038
Somatic FGFR2 is Required for Germ Cell Maintenance in the Mouse Ovary., PMID:36786658
Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet-Induced Adiposity., PMID:36755192
R-spondin family biology and emerging linkages to cancer., PMID:36645115
For research use only. Not for human or drug use.
