Catalog No.
YHH35701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala301
Predicted molecular weight
36.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16719
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KYNU, Kynureninase, L-kynurenine hydrolase
Exploring causal plasma protein level ratios and potential drug targets for depression: A proteomics Mendelian randomization study., PMID:40499826
GPX4 knockdown suppresses M2 macrophage polarization in gastric cancer by modulating kynurenine metabolism., PMID:40365295
Identification of the shared gene signatures and biological mechanism in type 2 diabetes mellitus and hepatocellular carcinoma., PMID:40303585
Breast cancer metastasis progression is associated with elevated activity of kynurenine monooxygenase and kynureninase., PMID:39558063
Elucidating common biomarkers and pathways of osteoporosis and aortic valve calcification: insights into new therapeutic targets., PMID:39537712
Gene expression of kynurenine pathway enzymes in depression and following electroconvulsive therapy., PMID:39417574
Characterization of Circulating Protein Profiles in Individuals with Prader-Willi Syndrome and Individuals with Non-Syndromic Obesity., PMID:39407757
Rhodoquinone-dependent electron transport chain is essential for Caenorhabditis elegans survival in hydrogen sulfide environments., PMID:39178951
Neurological-related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity., PMID:39075931
Evaluation of Kynu, Defb2, Camp, and Penk Expression Levels as Psoriasis Marker in the Imiquimod-Induced Psoriasis Model., PMID:39045230
Dissecting gastric cancer heterogeneity and exploring therapeutic strategies using bulk and single-cell transcriptomic analysis and experimental validation of tumor microenvironment and metabolic interplay., PMID:38962317
Developing a novel immune infiltration-associated mitophagy prediction model for amyotrophic lateral sclerosis using bioinformatics strategies., PMID:38601155
KYNU Expression Promotes Cisplatin Resistance in Esophageal Cancer., PMID:38577600
Identification of potential drug targets for allergic diseases from a genetic perspective: A mendelian randomization study., PMID:38573314
A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder., PMID:38357931
Identification of potential crucial genes shared in psoriasis and ulcerative colitis by machine learning and integrated bioinformatics., PMID:38303405
On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging., PMID:38097593
Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease., PMID:37988864
Kynureninase knockdown inhibits cisplatin resistance in vivo and in vitro and impacts the prognosis of cervical adenocarcinoma., PMID:37742026
Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis., PMID:37621179
Bioinformatic Analysis of the Potential Common Pathogenic Mechanisms for Psoriasis and Metabolic Syndrome., PMID:37222907
Identification of novel interacts partners of ADAR1 enzyme mediating the oncogenic process in aggressive breast cancer., PMID:37221310
Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism., PMID:37138031
Plasma levels of neurology-related proteins are associated with cognitive performance in an older population with overweight/obesity and metabolic syndrome., PMID:36964401
Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis., PMID:36765792
Organ Protection by Caloric Restriction Depends on Activation of the De Novo NAD+ Synthesis Pathway., PMID:36758124
Targeted proteomic scan identifies alteration of serum proteins among workers occupationally exposed to low levels of trichloroethylene., PMID:36346153
Tryptophan metabolism and disposition in cancer biology and immunotherapy., PMID:36286592
IDO promotes the proliferation and invasion of prostate cancer cells through KYNU., PMID:36264416
Identification and characterization of the kynurenine pathway in the pond snail Lymnaea stagnalis., PMID:36114337
Mouse Model of Weak Depression Exhibiting Suppressed cAMP Signaling in the Amygdala, Lower Lipid Catabolism in Liver, and Correlated Gut Microbiota., PMID:35928791
Differential Gene Expression and Methylation Analysis of Melanoma in TCGA Database to Further Study the Expression Pattern of KYNU in Melanoma., PMID:35893303
HIV-1 Tat and cocaine impact astrocytic energy reservoirs and epigenetic regulation by influencing the LINC01133-hsa-miR-4726-5p-NDUFA9 axis., PMID:35892093
Human 5-lipoxygenase regulates transcription by association to euchromatin., PMID:35878796
Further characterization of tryptophan metabolism and its dysregulation in fibroids., PMID:35715314
Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma., PMID:35626147
Further description of two patients with biallelic variants in NADSYN1 in association with cardiac and vertebral anomalies., PMID:35491967
Re-sequencing of candidate genes FOXF1, HSPA6, HAAO, and KYNU in 522 individuals with VATER/VACTERL, VACTER/VACTERL-like association, and isolated anorectal malformation., PMID:35362267
Yixin Ningshen Tablet Alleviates Comorbidity of Myocardial Infarction and Depression by Enhancing Myocardial Energy Metabolism and Increasing Availability of Monoamine Neurotransmitter., PMID:35319073
The TZM-bl Reporter Cell Line Expresses Kynureninase That Can Neutralize 2F5-like Antibodies in the HIV-1 Neutralization Assay., PMID:35054825
The Role and Mechanism of SIRT6 in Regulating Phenotype Transformation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm., PMID:35035519
Alterations in Kynurenine and NAD+ Salvage Pathways during the Successful Treatment of Inflammatory Bowel Disease Suggest HCAR3 and NNMT as Potential Drug Targets., PMID:34948292
A metabolism-relevant signature as a predictor for prognosis and therapeutic response in pancreatic cancer., PMID:34632851
DNA Damage, n-3 Long-Chain PUFA Levels and Proteomic Profile in Brazilian Children and Adolescents., PMID:34444642
Cancer-associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T-cell suppression., PMID:34379869
Genetic Analysis of Tryptophan Metabolism Genes in Sporadic Amyotrophic Lateral Sclerosis., PMID:34194442
Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis., PMID:34177888
TDO2 knockdown inhibits colorectal cancer progression via TDO2-KYNU-AhR pathway., PMID:34051337
Changes in gene expression of adipose tissue CD14+ cells in patients with Type 2 diabetes mellitus and their relationship with environmental factors., PMID:33678630
KYNU, a novel potential target that underpins CD44-promoted breast tumour cell invasion., PMID:33486887
For research use only. Not for human or drug use.
