Catalog No.
YHH31801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys32-His430
Predicted molecular weight
46.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16620
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB, TRKB, NTRK2, Tropomyosin-related kinase B, BDNF/NT-3 growth factors receptor, Trk-B
Sex- and subregion-specific vulnerability of the hippocampus and amygdala to intermittent hypoxia in relation to learning/memory function and anxiety tendencies of infant rats., PMID:40490588
The physiopathology of brain-derived neurotrophic factor., PMID:40490314
Prolonged nicotine exposure, via electronic cigarette, selectively increases Bdnf/TrkB transcription, dynorphin peptide levels and OLIG2 in male rat VTA., PMID:40460907
Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age., PMID:40449249
Gastrodia elata polysaccharide alleviates depression via gut microbiota modulation and Keap1-Nrf2/BDNF-TrkB pathway activation., PMID:40447013
Kirenol alleviates cerebral ischemic injury by promoting synaptic plasticity via HDAC2-mediated BDNF expression., PMID:40446576
The role of LINGO-1 in regulating CB1R/TrkB signalling and GABAergic interneurons in Alzheimer's disease pathogenesis., PMID:40441519
BDNF/proBDNF Interplay in the Mediation of Neuronal Apoptotic Mechanisms in Neurodegenerative Diseases., PMID:40430064
Neurotrophic and Neurotoxic Effects of Aβ42 and Its Oligomers on Neuronal Survival: Revealed by Their Opposite Influence on the Potency of Extracellular BDNF., PMID:40429646
Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition., PMID:40426267
Psilocybin and psilocin regulate microglial immunomodulation and support neuroplasticity via serotonergic and AhR signaling., PMID:40424654
Oncogenic role of the brain‑derived neurotrophic factor‑TrkB axis with a focus on gallbladder cancer (Review)., PMID:40417878
The Effects of Treadmill Exercise on the Recovery of Synaptic Plasticity in Septic Mice: A Focus on Brain-Derived Neurotrophic Factor/Tropomyosin-Related Kinase B Signaling., PMID:40408291
The Intricate Relationship of Trk Receptors in Brain Diseases and Disorders., PMID:40408027
MiR-134-5p/BDNF/TrkB/CREB signaling pathway involved in the depression-like behaviors in mice following exposure to benzo[a]pyrene., PMID:40407953
Early maternal separation potentiates the impact of later social isolation in inducing depressive-like behavior via oxidative stress in adult rats., PMID:40389583
The leptin/BDNF/TrkB signaling pathway improves corticosteroid combined with chronic restraint stress-induced depressive-like behavior in mice., PMID:40389053
Unlocking Alzheimer's Disease: The Role of BDNF Signaling in Neuropathology and Treatment., PMID:40380033
S-ketamine ameliorates post-stroke depression in mice via attenuation of neuroinflammation, synaptic restoration, and BDNF pathway activation., PMID:40367907
BDNF alleviates senescence and enhances osteogenic differentiation in bone marrow mesenchymal stem cells via the TrkB/PI3K/AKT pathway., PMID:40367890
Oral 7,8-Dihydroxyflavone Protects Retinal Ganglion Cells by Modulating the Gut-Retina Axis and Inhibiting Ferroptosis via the Indoleacrylic Acid-AhR-ALDH1A3-FSP1 Pathway., PMID:40365730
From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine., PMID:40362507
Deciphering the polypharmacology of Dingzhi Xiaowan against comorbid depression: Integrated metabolomics of brain tissue and network pharmacology analysis in chronic restraint stress (CRS)-LPS model., PMID:40350046
Antidepressant effects of ershiwei roudoukou pills and its active ingredient Macelignan: Multiple mechanisms involving oxidative stress, neuroinflammation and synaptic plasticity., PMID:40346051
(R)-ketamine induces mGlu5 receptor-dependent antidepressant-like effects in the chronic unpredictable mild stress model of depression in mice., PMID:40342162
Enhanced ERK activity extends ketamine's antidepressant effects by augmenting synaptic plasticity., PMID:40339008
A novel Dual GLP-1/CCK Receptor Agonist Improves Cognitive Performance and Synaptogenesis in the 5 × FAD Alzheimer Mouse Model., PMID:40338455
Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schizophrenia cases with high inflammation., PMID:40335479
Low concentration of quercetin promotes BDNF expression and osteoblast differentiation during fracture healing via TrkB-ERK1/2 signaling pathway., PMID:40334810
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats., PMID:40328154
Aminooxyacetic acid ameliorates alcohol-induced learning and memory deficits through BDNF-TrkB pathway and calcium homeostasis., PMID:40325392
The Research Progress of Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusions and Tropomyosin Receptor Kinase (TRK) Inhibitors: A Narrative Review., PMID:40321931
Hypoxic preconditioning modulates BDNF signaling to alleviate depression-like behaviors in mice and its whole transcriptome sequencing analysis., PMID:40316595
Protective effects of dexmedetomidine against propofol-induced memory impairment in developing rat involved Src and RARα., PMID:40296644
Amomum tsao-ko Attenuates Hyperglycemia and Cognitive Impairment via Regulating Gut Microbiota, SCFAs, and CREB/BDNF/TrkB Signaling Pathway in T2DM Mice., PMID:40296313
7,8-Dihydroxyflavone provides neuroprotection and rescues behavioral deficits in Angiostrongylus cantonensis-infected mice by ameliorating synaptic loss., PMID:40287337
Truncated TrkB: The predominant TrkB isoform in nociceptors., PMID:40280290
Therapeutic effects of resveratrol on memory deficits in offspring of sleep-deprived rats: Involvement of hippocampal BDNF-TrkB pathways., PMID:40270329
Therapeutic Targets and Molecular Mechanisms of Calycosin in the Treatment of Depression: Insights From Chronic Mild Stress Animal Models., PMID:40260589
Alpha-Pinene Ameliorates Memory Deficits in 3-Nitropropionic Acid-Induced Rat Model of Huntington's Disease., PMID:40237934
A brain-accessible peptide modulates stroke inflammatory response and neurotoxicity by targeting BDNF-receptor TrkB-T1 specific interactome., PMID:40225562
A sensitive period for the development of episodic-like memory in mice., PMID:40215964
BDNF Signaling and Pain Modulation., PMID:40214430
Dysregulation of proBDNF/p75NTR and BDNF/TrkB Signaling in Acute Ischemic Stroke: Different Sides of the Same Coins., PMID:40209946
Ca2+/calmodulin-dependent protein kinase II regulates the inflammatory hDPSCs dentino-differentiation via BDNF/TrkB receptor signaling., PMID:40206401
Ketogenic diet attenuates neuroinflammation and restores hippocampal neurogenesis to improve CUMS induced depression-like behavior in mice., PMID:40197680
Intranasal Delivery of Brain-Derived Neurotrophic Factor (BDNF)-Loaded Small Extracellular Vesicles for Treating Acute Spinal Cord Injury in Rats and Monkeys., PMID:40194993
The combined damage of bisphenol A and high fat diet to learning and memory in young male mice: the regulatory effect of BDNF/TrkB/PI3K/AKT pathway on autophagy., PMID:40187395
Role of brain-derived neurotrophic factor in frailty: From mechanisms to interventions., PMID:40187046
Linagliptin mitigates lipopolysaccharide-induced acute kidney injury in mice: Novel renal BDNF/TrkB/NRF2-dependent antioxidant, anti-inflammatory, and antiapoptotic mechanisms., PMID:40185468
For research use only. Not for human or drug use.
