Catalog No.
YHH20001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys20-Ile355
Predicted molecular weight
39.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15796
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mothers against decapentaplegic homolog 2, SMAD 2, SMAD2, JV18-1, Mad-related protein 2, hMAD-2, MADR2, Mothers against DPP homolog 2, SMAD family member 2, MADH2, Smad2, hSMAD2, MAD homolog 2
Phosphocreatine alleviates liver fibrosis in diabetic mice by targeting TGF-β/Smad and α-SMA pathways., PMID:40513426
Mechanism of Sangqi Qingxuan Liquid in Alleviating Vascular Endothelial Injury in Hypertension Focuses on β-Catenin., PMID:40512366
Tacrolimus Modulates TGF-β Signaling-Related Genes and MicroRNAs in Human Retinal Pigment Epithelial Cells Activated by Lipopolysaccharide., PMID:40508210
FOXO1 contributes to cigarette smoke condensate-induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway., PMID:40498253
Ligand-specific regulation of a binary enhancer code dictating cellular senescence., PMID:40493192
MiR-155-5p Inhibits Multiple Myeloma Cell Malignancy and Tumorigenesis by Targeting JARID2 and Inactivating the TGFβ/SMAD2 Signaling., PMID:40488275
Amygdalin Alleviates Airway Inflammation and Remodeling in Asthma Mice: Involvement of TGF-β1/Smads Signaling Pathway., PMID:40485525
Propofol-mediated inhibition of ovarian function by mitophagy over-activation via TGF-β1/SMAD2/3 signaling pathway., PMID:40480431
Plasma exosome proteomics reveals upregulation of CILP-1 in concave side of paraspinal muscle in adolescent idiopathic scoliosis., PMID:40461962
RGS3 acts as a tumor promoter by facilitating the regulation of the TGF-β signaling pathway and promoting EMT in ovarian cancer., PMID:40456746
FSTL-1 as a Novel Cardiokine of Cardiac Angiogenesis: A Systematic Review., PMID:40453420
Finerenone alleviates the high glucose-induced fibrosis in HK-2 cells by inhibiting EMT via the TGF-β1/Smads signaling., PMID:40436765
Growth differentiation factor-8 promotes human extravillous trophoblast cell invasion by increasing ANGPTL4 expression., PMID:40435667
MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3., PMID:40425777
SMAD2 S-palmitoylation promotes its linker region phosphorylation and TH17 cell differentiation in a mouse model of multiple sclerosis., PMID:40424363
GDF15 suppresses abdominal aortic aneurysm by upregulating AREG expression to adjust macrophage polarization., PMID:40414071
Primary cilium restricts TGF-β/SMAD signaling induced RIBEs in the co-culture model., PMID:40412783
LncRNA SNHG12 promotes EMT and metastasis of colorectal cancer via regulating TGF-β/Smad2/3 signaling pathway., PMID:40412277
Effect and mechanism of Nintedanib on acute and chronic radiation-induced lung injury in mice., PMID:40408456
PERK Regulates Epithelial-Mesenchymal Transition Through Autophagy and Lipid Metabolism in Lens Epithelial Cells., PMID:40408092
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity., PMID:40407837
Autophagic degradation of SQSTM1 enables fibroblast activation to accelerate wound healing., PMID:40400126
Lycium barbarum glycopeptide reduces inflammation and fibrosis in corneal injury by modulating the NF-κB/NLRP3/IL-1 β signaling pathway and microRNA-21a-5p/SMAD7., PMID:40398709
Functional metabolomics revealed pyroglutamic acid may play a key role in idiopathic pulmonary fibrosis., PMID:40398246
Structural insights into the binding of human TGIF1 with SMAD2 MH2 domain., PMID:40395157
Taraxacum mongolicum total triterpenoids and taraxasterol ameliorate benign prostatic hyperplasia by inhibiting androgen levels, inflammatory responses, and epithelial-mesenchymal transition via the TGFβ1/Smad signalling pathway., PMID:40393639
Mesenchymal stem cell exosomes regulate TGFβ/Smad3 by decreasing the METTL3-NEAT1 axis to inhibit scar progression after breast surgery., PMID:40392368
Transcriptome and Proteome Analysis Identify Decorin as a Principal Antifibrotic Component Trapping TGF-β1 Within Adipose-Derived Stem Cell Secretome., PMID:40386129
Nintedanib regulates miR-23b-3p/TGFBR2 axis and competitively binds to TGFBR2 protein, inhibiting EMT process in human pterygium cells., PMID:40385123
Selective JAK-1 inhibitor Upadacitinib and peptide PD29 modulate the JAK and TGF-β/Smad signaling pathways reducing experimental dermal fibrosis., PMID:40381666
Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development., PMID:40372775
Phosphatase-independent activity of smooth-muscle calcineurin orchestrates a gene expression program leading to hypertension., PMID:40367288
In silico prediction of GRP78-CRIPTO binding sites to improve therapeutic targeting in glioblastoma., PMID:40360533
Gestational Exposure to Phenanthrene Induces Superfluous Fibrosis and Calcification and Metabolic Imbalance of the Placenta in Mice., PMID:40359265
Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degeneration., PMID:40356987
Rubus coreanus extract prevents kidney fibrosis through TGF-β/Smad pathway inhibition., PMID:40354602
Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer., PMID:40348815
From stem cells to skin: ADSCP6 peptide's role in transforming scar therapy., PMID:40348095
Drugs targeting novel pathways in pulmonary arterial hypertension., PMID:40341051
MRI-based machine learning reveals proteasome subunit PSMB8-mediated malignant glioma phenotypes through activating TGFBR1/2-SMAD2/3 axis., PMID:40335825
CASK promotes prostate cancer progression via kinase-dependent activation of AKT., PMID:40327999
Icaritin Attenuates HSC Activation by Down-regulating the HIF-1α and TGF-β/Smad Signaling Pathways to Ameliorate Liver Fibrosis., PMID:40326028
Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF-β/Smad2/3 Signaling in Mice., PMID:40323694
Protective effects and mechanisms of cynaroside on renal fibrosis in mice with unilateral ureteral obstruction., PMID:40322965
Discovery of Novel Cyclic Peptides as SMAD2-SMAD4 Interaction Inhibitors for the Treatment of Hepatic Fibrosis., PMID:40320643
CD147 inhibition reduced fibronectin expression in TGF-β1-induced keloid fibroblasts by targeting Smad2 signaling pathway., PMID:40319830
Procyanidin C1 ameliorates aging-related skin fibrosis through targeting EGFR to inhibit TGFβ/SMAD pathway., PMID:40315640
Sirtuin1 Promotes the Migration of Cells and Reduces the Accumulation of Extracellular Matrix in Trabecular Meshwork Cells Induced by Transform Growth Factor-β via Smads System., PMID:40287804
Inhibition of M2 macrophage-mediated mesenchymal stem cell migration: Boldine attenuates elbow heterotopic ossification., PMID:40287052
Mechanism of Green Tea Peptides in Lowering Blood Pressure and Alleviating Renal Injury Induced by Hypertension Through the Ang II/TGF-β1/SMAD Signaling Pathway., PMID:40284165
For research use only. Not for human or drug use.
