Catalog No.
YHH06101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys29-Asn278
Predicted molecular weight
30.59 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15303
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HER4, Tyrosine kinase-type cell surface receptor HER4, p180erbB4, s80HER4, ERBB4, 4ICD, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, E4ICD
Modeling acquired TKI resistance and effective combination therapeutic strategies in murine RET+ lung adenocarcinoma., PMID:40502048
7,7-Bis(3-Indolyl)-p-Cresol, a Metabolite from Marine-Derived Bacterium Vibrio spp. DJA11, Suppresses the Proliferation and Motility of Prostate Cancer Cells., PMID:40374533
Exploring Neuregulin3: From physiology to pathology, a novel target for rational drug design., PMID:40320052
Clinicopathological and molecular characterization of KRAS wild-type pancreatic ductal adenocarcinomas reveals precursor lesions with oncogenic mutations and fusions in RAS pathway genes., PMID:40317966
Prenatal exposure to Bisphenol A sex-specifically disrupts prepulse inhibition and decreases parvalbumin-positive neurons in the prefrontal cortex of adult rats., PMID:40311724
Prefrontal ErbB4-positive interneurons for avoidance., PMID:40310724
SH003 Inhibits Proliferation and Induces Apoptosis in NSCLC Cell Lines by Inhibiting the Receptor Tyrosine Kinase-related Pathway., PMID:40295074
Multiple Roles for Neuregulins and Their ERBB Receptors in Neurodegenerative Disease Pathogenesis and Therapy., PMID:40254133
ERBB4 as a therapeutic target in aortic dissection: Implications for cell-based therapies in vascular regeneration., PMID:40227858
The dynamics of chemoattractant receptors redistribution in the electrotaxis of 3T3 fibroblasts., PMID:40200280
Application of promoting blood circulation and resolving blood stasis in intracerebral hemorrhage: a traditional method gradually being reconsidered., PMID:40151133
The Status of SOX2 Expression in Gastric Cancers with Induction of CDX2 Defines Groups with Different Genomic Landscapes., PMID:40149431
10-Methoxy-leonurine accelerated wound healing through ErbB4/PI3K-AKT pathway., PMID:40118194
Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model., PMID:40089796
EGF receptor in organ development, tissue homeostasis and regeneration., PMID:39966897
Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway., PMID:39959423
The Brain-Penetrant Pan-ErbB Inhibitor Poziotinib Effectively Targets HER2+ Breast Cancer Brain Metastases., PMID:39932819
The role of the neuregulin 1-ErbB4 signaling pathway in neurological disorders., PMID:39923224
Exercise Training After Myocardial Infarction Enhances Endothelial Progenitor Cells Function via NRG-1 Signaling., PMID:39893285
Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling., PMID:39891907
ERBB4 selectively amplifies TGF-β pro-metastatic responses., PMID:39854208
LncRNA GAS5 reduces blood glucose levels and alleviates renal fibrosis in diabetic nephropathy by regulating the miR-542-3p/ERBB4 axis., PMID:39849629
Identification of clinicopathological-specific driver gene and genetic subtyping of colorectal cancer., PMID:39797621
Small-molecule-induced ERBB4 activation to treat heart failure., PMID:39794341
Injury-induced Neuregulin-ErbB signaling from muscle mobilizes stem cells for whole-body regeneration in Acoels., PMID:39764063
Dehydroevodiamine Alleviates Doxorubicin-Induced Cardiomyocyte Injury by Regulating Neuregulin-1/ErbB Signaling., PMID:39742014
The Putative Antilipogenic Role of NRG4 and ERBB4: First Expression Study on Human Liver Samples., PMID:39735994
NRG1-ErbB4 signaling in the cerebrospinal fluid-contacting nucleus regulates thermal pain in mice., PMID:39733821
[Protective effect of Anmeidan on hippocampal neuronal damage and synaptic microenvironment in sleep-deprived rats based on NRG1/ErbB4 signaling pathway]., PMID:39701678
ERBB2/ERBB3-mutated S100/SOX10-positive uterine sarcoma: something new., PMID:39666109
The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI., PMID:39635532
ErbB4 precludes the occurrence of PTSD-like fear responses by supporting the bimodal activity of the central amygdala., PMID:39623093
Structure-based pharmacophore modelling for ErbB4-kinase inhibition: a systematic computational approach for small molecule drug discovery for breast cancer., PMID:39621018
ErbB deletion effect on pulmonary intracellular surfactant distribution., PMID:39618116
Emodin disrupts the KITENIN oncogenic complex by binding ErbB4 and suppresses colorectal cancer progression in dual blockade with KSRP-binding compound., PMID:39586126
Pre-radiation Nivolumab plus ipilimumab in patients with newly diagnosed high-grade gliomas., PMID:39572979
Establishing a new human lung squamous cell carcinoma cell line, OMUL-1, expressing insulin-like growth factor 1 receptor and programmed cell death ligand 1., PMID:39552203
Retraction notice to "The novel antibody fusion protein rhNRG1-HER3i promotes heart regeneration by enhancing NRG1-ERBB4 signaling pathway" [Journal of Molecular and Cellular Cardiology 187 (2023) 26-37]., PMID:39551682
ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome., PMID:39543371
Neuregulin 4 Downregulation Alters Mitochondrial Morphology and Induces Oxidative Stress in 3T3-L1 Adipocytes., PMID:39519269
Overexpressed nicotinamide N‑methyltransferase in endometrial stromal cells induced by macrophages and estradiol contributes to cell proliferation in endometriosis., PMID:39489776
Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment., PMID:39482781
Isothiocyanates attenuate heparin-induced proliferation of colon cancer cells in vitro., PMID:39479720
Discovery of novel Macrocyclic small molecules Based on 2-Amino-4-thiazolylpyridineas selective EGFR inhibitors with high Blood-Brain barrier penetration for the treatment of glioblastoma., PMID:39476599
Denervation‑induced NRG3 aggravates muscle heterotopic ossification via the ErbB4/PI3K/Akt signaling pathway., PMID:39450542
Targeted Genetic Sequencing Analysis of 223 Cases of Pseudomyxoma Peritonei Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Shows Survival Related to GNAS and KRAS Status., PMID:39435876
Systemic ALK-negative anaplastic large cell lymphoma: Insights into morphologic, immunophenotypic, genetic and molecular characteristics., PMID:39424106
MicroRNA expression profiles in plasma exosomes of late pregnant giant pandas., PMID:39422788
The influence of the NRG1/ERBB4 signaling pathway on pulmonary artery endothelial cells., PMID:39411231
The role and mechanism of NRG1/ErbB4 in inducing the differentiation of induced pluripotent stem cells into cardiomyocytes., PMID:39407109
For research use only. Not for human or drug use.
