Catalog No.
YHG99401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg323-Arg553
Predicted molecular weight
28.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15046
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0070, KARS, Lysyl-tRNA synthetase, LysRS, Lysine--tRNA ligase, KARS1
Lysyl-tRNA synthetase 1 promotes atherogenesis via autophagy-related secretion and inflammation., PMID:40169806
Assembly of the Human Multi-tRNA Synthetase Complex Through Leucine Zipper Motifs., PMID:39542129
Novel Cases of Non-Syndromic Hearing Impairment Caused by Pathogenic Variants in Genes Encoding Mitochondrial Aminoacyl-tRNA Synthetases., PMID:39062730
Expansion of the phenotypic spectrum of KARS1-related disorders to include arthrogryposis multiplex congenita and summary of experiences with lysine supplementation., PMID:38980148
Antibody Deficiency in Patients with Biallelic KARS1 Mutations., PMID:37770806
Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death., PMID:36242734
Changes in subcellular localization of Lysyl-tRNA synthetase and the 67-kDa laminin receptor in epithelial ovarian cancer metastases., PMID:35912727
Bi-allelic KARS1 pathogenic variants affecting functions of cytosolic and mitochondrial isoforms are associated with a progressive and multisystem disease., PMID:33942428
The complex relationship between MITF and the immune system: a Melanoma ImmunoTherapy (response) Factor?, PMID:33276788
Biallelic variants in LARS2 and KARS cause deafness and (ovario)leukodystrophy., PMID:30737337
Lysyl-tRNA synthetase-expressing colon spheroids induce M2 macrophage polarization to promote metastasis., PMID:30188867
Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism., PMID:28887846
Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells., PMID:28611052
Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP., PMID:28003362
Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell‑extracellular matrix adhesion for migration., PMID:26891990
Activation of human mitochondrial lysyl-tRNA synthetase upon maturation of its premitochondrial precursor., PMID:22235746
Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response., PMID:15851690
For research use only. Not for human or drug use.
