Catalog No.
YHG93501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala349
Predicted molecular weight
40.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14973
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cell growth-inhibiting gene 29 protein, Sodium/taurocholate cotransporting polypeptide, NTCP, SLC10A1, Sodium/bile acid cotransporter, Na(+)/taurocholate transport protein, Solute carrier family 10 member 1, Na(+)/bile acid cotransporter
Correction of a Traffic-Defective Missense ABCB11 Variant Responsible for Progressive Familial Intrahepatic Cholestasis Type 2., PMID:40508041
The proteomic differences and expression of fatty acid-binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone., PMID:40405508
Sodium taurocholate co-transporting polypeptide deficiency attenuates acetaminophen-induced hepatotoxicity via regulating expression of drug metabolism enzymes in mice., PMID:39947258
Desmodium styracifolium (Osb.) Merr. Extracts alleviate cholestatic liver disease by FXR pathway., PMID:39454708
Structure-Activity Relationships and Target Selectivity of Phenylsulfonylamino-Benzanilide Inhibitors Based on S1647 at the SLC10 Carriers ASBT, NTCP, and SOAT., PMID:39419503
Epigenetic regulation of thyroid hormone action in human metabolic dysfunction-associated steatohepatitis., PMID:39312733
The loss of hepatitis B virus receptor NTCP/SLC10A1 in human liver cancer cells is due to epigenetic silencing., PMID:39297647
Sodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide., PMID:38901675
SLC10A1 rs2296651 variant (S267F mutation) predicts biochemical traits, hepatitis B virus infection susceptibility and the risk of gallstone disease., PMID:38869622
3,3',5-Triiodothyroacetic Acid Transporters., PMID:38836423
Neonatal jaundice caused by compound mutations of SLC10A1 and a novel UGT1A1 gene., PMID:38588793
Evolutionary analysis of SLC10 family members and insights into function and expression regulation of lamprey NTCP., PMID:38429619
Sodium taurocholate cotransporter polypeptide deficiency from two pairs of twins with homozygous and heterozygous of p.Ser267Phe variant, respectively: Case report., PMID:38369284
The Mutational Landscape Of Genetic Cholestatic Diseases In Pakistani Children., PMID:37697751
LINC00659 Inhibits Hepatocellular Carcinoma Malignant Progression by Blocking Aerobic Glycolysis through FUS Recruitment and SLC10A1 Modulation., PMID:37234237
Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans., PMID:37146714
Interactions of Na+/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy., PMID:37103224
Serum miR-4488 as a potential biomarker of lean nonalcoholic fatty liver disease., PMID:36923095
The Clinical Relevance and Immune Correlation of SLC10 Family Genes in Liver Cancer., PMID:36606115
Pegylated interferon therapy-related microRNA-6126 downregulates sodium taurocholate cotransporting polypeptide expression in hepatocytes., PMID:36427676
In Vitro Rescue of the Bile Acid Transport Function of ABCB11 Variants by CFTR Potentiators., PMID:36142670
Treprostinil Supplementation Ameliorates Hepatic Ischemia Reperfusion Injury and Regulates Expression of Hepatic Drug Transporters: An Isolated Perfused Rat Liver (IPRL) Study., PMID:36071353
SLCO1B1 and SLC10A1 polymorphism and plasma rifampin concentrations in patients with co-morbidity tuberculosis-diabetes mellitus in Baja California, Mexico., PMID:36055153
Oligomerization of the HBV/HDV functional receptor NTCP expressed in Sf9 insect cell., PMID:35944837
NTCP Deficiency Affects the Levels of Circulating Bile Acids and Induces Osteoporosis., PMID:35937832
Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies., PMID:35807880
Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation., PMID:35806468
Tyrosine 146 of the Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes., PMID:35746730
IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and Infection., PMID:35458456
Gene Expression Profiling of 1α,25(OH)2 D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes., PMID:35184385
De novo mutation loci and clinical analysis in a child with sodium taurocholate cotransport polypeptide deficiency: A case report., PMID:35071582
Multitasking Na+/Taurocholate Cotransporting Polypeptide (NTCP) as a Drug Target for HBV Infection: From Protein Engineering to Drug Discovery., PMID:35052874
Layered Double Hydroxide Modified with Deoxycholic and Hyaluronic Acids for Efficient Oral Insulin Absorption., PMID:34880612
Dihydroartemisinin improves hypercholesterolemia in ovariectomized mice via enhancing vectorial transport of cholesterol and bile acids from blood to bile., PMID:34847494
Sodium taurocholate co-transporting polypeptide deficiency., PMID:34757153
A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis., PMID:34585848
Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics., PMID:34497279
Clinical characterization of NTCP deficiency in paediatric patients : A case-control study based on SLC10A1 genotyping analysis., PMID:34369070
Messenger RNA Expression of Albumin, Transferrin, Transthyretin, Asialoglycoprotein Receptor, Cytochrome P450 Isoform, Uptake Transporter, and Efflux Transporter Genes as a Function of Culture Duration in Prolonged Cultured Cryopreserved Human Hepatocytes as Collagen-Matrigel Sandwich Cultures: Evidence for Redifferentiation upon Prolonged Culturing., PMID:34135090
Substrate Specificities and Inhibition Pattern of the Solute Carrier Family 10 Members NTCP, ASBT and SOAT., PMID:34079822
Functional and Pharmacological Comparison of Human and Mouse Na+/Taurocholate Cotransporting Polypeptide (NTCP)., PMID:34060352
Rotor Syndrome: Glucuronidated Bile Acidemia From Defective Reuptake by Hepatocytes., PMID:33860121
Hyperosmolarity stimulates transporter-mediated insertion of estrone sulfate into the plasma membrane, but inhibits the uptake by SLC10A1 (NTCP)., PMID:33617845
Mouse NTCP-Mediated Rosuvastatin Uptake In Vitro and in Slc10a1-Deficient Mice., PMID:33404849
Unique Variant of Cerebrotendinous Xanthomatosis Presenting With Eyelid Involvement Due to Heterozygous CYP7A1 and SLC10A1 Gene Mutations., PMID:33298707
Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology., PMID:33222321
Identification and characterization of dynamically regulated hepatitis-related genes in a concanavalin A-induced liver injury model., PMID:33221747
Transient, Tunable Expression of NTCP and BSEP in MDCKII Cells for Kinetic Delineation of the Rate-Determining Process and Inhibitory Effects of Rifampicin in Hepatobiliary Transport of Taurocholate., PMID:33159914
Abnormal Bilirubin Metabolism in Patients With Sodium Taurocholate Cotransporting Polypeptide Deficiency., PMID:33093374
NTCP gene polymorphisms and hepatitis B virus infection status in a Ghanaian population., PMID:32620148
For research use only. Not for human or drug use.
