Catalog No.
YHG80901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu31-Phe124
Predicted molecular weight
12.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14508
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Epididymal secretory protein E4, Major epididymis-specific protein E4, HE4, WFDC2, WAP5, WAP four-disulfide core domain protein 2, Putative protease inhibitor WAP5
Accurate prediction of benign and malignant adnexal tumors in surgical resection and conservative treatment: construction and external validation of a diagnostic model based on CEUS, HE4, and O-RADS US v2022 evaluation., PMID:40481532
Plasma proteomic profiles for early detection and risk stratification of non-small cell lung carcinoma: A prospective cohort study with 52,913 participants., PMID:40480837
Comparison of sensitivity for Risk of Ovarian Malignancy Algorithm (ROMA) and Assessment of Different NEoplasias in the adneXa (ADNEX) model for predicting ovarian cancer in a woman with adnexal masses., PMID:40319538
Clinical significance of human epididymis protein 4 (HE4), cancer antigen 125 (CA125), the risk of ovarian malignancy algorithm (ROMA), and Copenhagen index (CPH-I) for the diagnosis of endometrial carcinoma., PMID:40270170
Diagnostic value of CEACAM6 and HE4 in pleural fluid for malignant pleural effusion., PMID:40232301
Early-Stage Lung Cancer Diagnosis by a Point-of-Care Electrochemical Aptamer-Based Sensor of NAP2 in Human Serum., PMID:40215095
Tumor marker elevations in chronic kidney disease: a retrospective study., PMID:40191749
The predictive prognostic value of serum CEA, CA153, HE4 combined with a variety of immune inflammatory indicators in breast cancer., PMID:40190530
Role of HE4 in evaluation of adnexal masses and its comparison with CA125, ROMA and RMI in premenopausal women., PMID:40190516
Prospective evaluation of 92 protein biomarkers for early detection of endometrial cancer., PMID:40177982
Sex-specific proteomic signatures improve cardiovascular risk prediction for the general population without cardiovascular disease or diabetes., PMID:40154735
The relationship between the expression of serum asprosin and miR-21 in patients with osteoporosis and delayed healing after OVCF surgery., PMID:40153558
CT83 Promotes Cancer Progression by Upregulation of PDL1 in Adenocarcinoma of the Cervix., PMID:40141328
A perspective on the potential use of aptamer-based field-effect transistor sensors as biosensors for ovarian cancer biomarkers CA125 and HE4., PMID:40120511
Two novel genetic variants in the WFDC2 gene from patients with bronchiectasis., PMID:40114242
Human epididymis secretory protein 4 in idiopathic inflammatory myopathy-associated interstitial lung disease., PMID:40095259
Relationship between HE4 levels and metabolic parameters in PET of non-small cell lung cancer patients., PMID:40083263
Column chart prediction model for ovarian cancer based on serum ovarian tumor related biomarkers and validation., PMID:40068807
Comparison of two automated immunoassays for quantifying ProGRP, SCC and HE4 in serum: impact on diagnostic accuracy., PMID:39954248
FSP1 expression as a predictor of platinum resistance and recurrence in epithelial ovarian cancer., PMID:39927929
Influences of age and sex on the diagnostic accuracy of human epididymis secretory protein 4 for malignant pleural effusion., PMID:39863671
The Evaluation of Urinary HE4, CEA, ProGRP, CYFRA 21-1 and NSE in the Diagnosis of Lung Cancer., PMID:39855745
Human epididymis protein 4-annexin II binding promotes aberrant epithelial-fibroblast crosstalk in pulmonary fibrosis., PMID:39833358
Multicenter study of ovarian cancer score for diagnosing ovarian cancer., PMID:39793443
Identifying proteins and pathways associated with multimorbidity in 53,026 adults., PMID:39740741
Value of miR200b and its combination with other biochemical markers in the diagnosis of epithelial ovarian cancer., PMID:39638936
Evaluation of serum human epididymis protein 4 in children with chronic liver diseases., PMID:39635859
Human epididymitis protein 4 as a biomarker of interstitial lung disease in patients with idiopathic inflammatory myopathies., PMID:39625826
The NF-κB-HE4 axis: A novel regulator of HE4 secretion in ovarian cancer., PMID:39621651
High-risk patient profiles for ovarian cancer: A new approach using cluster analysis of tumor markers., PMID:39617144
Proteomic and N-glycosylation analysis of fertile egg white during storage and incubation in chickens., PMID:39608286
Diagnostic accuracy of ultrasound classifications - O-RADS US v2022, O-RADS US v2020, and IOTA SR - in distinguishing benign and malignant adnexal masses: Enhanced by combining O-RADS US v2022 with tumor marker HE4., PMID:39541614
A Proteomics-Based Approach for Prediction of Different Cardiovascular Diseases and Dementia., PMID:39540306
Plasma proteomic signature of risk and prognosis of frailty in the UK Biobank., PMID:39535692
The diagnostic accuracy of HE4 in the differential diagnosis of pleural effusions., PMID:39528067
Diagnostic role of urine human epididymis protein 4 in ovarian cancer., PMID:39435168
The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma., PMID:39419971
Enhanced electrochemiluminescence of CdS QDs encapsulated in IRMOF-3 for sensitive detection of human epithelial protein 4., PMID:39418983
Correlation study of NF-κB, IER3, and Recurrence of Ovarian Endometrioid Cysts., PMID:39377902
Diagnostic performances of the Ovarian Adnexal Reporting and Data System, the Risk of Ovarian Malignancy Algorithm, and the Copenhagen Index in the preoperative prediction of ovarian cancer: a prospective cohort study., PMID:39344149
Increased serum human epididymis protein 4 is associated with disease activity and systemic involvement in pediatric-onset systemic lupus erythematosus., PMID:39318632
Potential for trans-pulmonary tumor markers in the early diagnosis of lung cancer: a case report., PMID:39294582
The Value of Human Epididymal Protein 4, Carcinoembryonic Antigen and Alpha-Fetoprotein in the Early Diagnosis of Cervical Cancer., PMID:39217979
Comprehensive serum glycopeptide spectra analysis to identify early-stage epithelial ovarian cancer., PMID:39198565
The clinical importance of IFN-γ and human epididymis protein 4 in Egyptian patients with epithelial ovarian cancer combined with HPV infection., PMID:39173571
Are there relationship otosclerosis with serum HE4 and CA125 level? A pilot study., PMID:39121351
Mediating and moderating effects of plasma proteomic biomarkers on the association between poor oral health problems and brain white matter microstructural integrity: the UK Biobank study., PMID:39080466
WFDC2 is a potential prognostic and immunotherapy biomarker in lung adenocarcinoma., PMID:39068532
Large-scale proteomics reveals precise biomarkers for detection of ovarian cancer in symptomatic women., PMID:39068297
Effect of human epididymis protein 4 on hyperoxia-induced bronchial dysplasia in newborn rats., PMID:39004907
For research use only. Not for human or drug use.
