Catalog No.
YHG80201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln13-Gln239
Predicted molecular weight
28.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14457
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BECN1, Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, GT197
Macrophage TRIM21 knockout inhibits septic acute lung injury by downregulating autophagy regulator protein ubiquitination., PMID:40509575
Investigating the impact of berberine on autophagy-mediated drug resistance in chronic lymphocytic leukemia tumor cells., PMID:40473844
BECN1 regulates ferroptosis induced by 2,4-dichlorophenoxyacetic acid in SH-SY5Y cells., PMID:40451026
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex., PMID:40442316
Capsaicin induces ferroptosis via suppression of SLC7A11 activity and upregulation of ACSL4 mediated by AMPK in tongue squamous cell carcinoma., PMID:40438695
Intestinal Microbiota and Gene Expression Alterations in Chinese Mitten Crab (Eriocheir sinensis) Under Deltamethrin Exposure., PMID:40427392
Oscillatory shear stress activates integrin β3, blocking autophagic flux in endothelial cells and promoting endothelial cells senescence., PMID:40412535
Neuronal activity triggers secretory autophagy to mediate the extracellular release of SNCA/α-synuclein., PMID:40395520
Autophagy Process in Parkinson's Disease Depends on Mutations in the GBA1 and LRRK2 Genes., PMID:40388077
Autophagy- and oxidative stress-related protein deregulation mediated by extracellular vesicles of human MJD/SCA3 iPSC-derived neuroepithelial stem cells and differentiated neural cultures., PMID:40374597
NSP6 regulates calcium overload-induced autophagic cell death and is regulated by KLHL22-mediated ubiquitination., PMID:40373961
Beclin-1-dependent autophagy protects perivascular adipose tissue function from hyperaldosteronism effects., PMID:40327449
Mechanism of Mitophagy to Protect Yak Kidney from Hypoxia-Induced Fibrosis Damage by Regulating Ferroptosis Pathway., PMID:40305351
Dual-specificity tyrosine-regulated kinase 4 modulates the STAT3-FOS signaling axis to inhibit hepatitis B virus replication via autophagy., PMID:40303300
NF-κB-mediated enhancement of H3K27me3 through EZH2: a mechanism to suppress pyocyanin-induced autophagy in macrophages., PMID:40301947
Rice stripe mosaic virus M protein antagonizes G-protein-induced antiviral autophagy in insect vectors., PMID:40300033
Perfluorooctanoic acid (PFOA) activates astrogliosis-associated neuroinflammation through ER stress-autophagy axis., PMID:40288163
The Protective Effect of Annexin A1 on Autophagy Via the CAMK2/BECN1 Signaling Pathway in PC12 Cells Stimulated with H2O2., PMID:40272685
tRF-3019A/STAU1/BECN1 axis promotes autophagy and malignant progression of colon cancer., PMID:40268078
RANKL promotes MT2 degradation and ROS production in osteoclast precursors through Beclin1-dependent autophagy., PMID:40267773
Rituximab-Chidamide combination chemotherapy enhances autophagy to overcome drug resistance in diffuse large B-cell lymphoma., PMID:40258315
IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming., PMID:40240362
TUT7-Mediated Uridine Degradation of MCPIP1 in the Pterygium to Regulate TRAF6-Mediated Autophagy., PMID:40238115
Lactoferrin influences atherosclerotic progression by modulating macrophagic AMPK/mTOR signaling-dependent autophagy., PMID:40148507
The Effect of Vitamin D3 Injection Combined With High-Intensity Interval Training on Excessive Autophagy in the Heart Tissue of Type 2 Diabetes-Induced Rats: An Analysis of the mTOR-Beclin-1-Fyco-1-Cathepsin D Pathway., PMID:40144137
TRIM21-driven K63-linked ubiquitination of RBM38c, as a novel interactor of BECN1, contributes to DNA damage-induced autophagy., PMID:40133668
Mechanistic insights into the kidney injury in chickens induced by hypervirulent fowl adenovirus serotype 4., PMID:40130861
Skeletal muscle preservation in arctic ground squirrels during hibernation season., PMID:40122513
Acacetin ameliorates pressure overload-induced cardiac remodeling by targeting USP10 and inhibiting maladaptive cardiomyocyte autophagy., PMID:40118748
Luteolin Inhibits Dexamethasone-Induced Osteoporosis by Autophagy Activation Through miR-125b-5p/SIRT3/AMPK/mTOR Axis, an In Vitro and In Vivo Study., PMID:40104207
ADSL-produced fumarate increases BECN1 dimethylation to promote autophagy and liver tumor growth., PMID:40103200
Immunohistochemical and bioinformatics analysis of the placental BCL-2 and Beclin-1 expressions in preeclampsia and HELLP syndrome., PMID:40094536
The Human Milk Oligosaccharide Lacto-N-Fucopentaose III Conjugated to Dextran Inhibits HIV Replication in Primary Human Macrophages., PMID:40077760
LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2., PMID:40066518
Cullin 3 mitigates nonesterified fatty acid-induced oxidative stress in mammary epithelial cells: Involvement of BCL2/BECN1 and autophagy., PMID:40054686
Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis., PMID:40032858
17β-estradiol delays cardiac aging through suppressing the methylation of Beclin1 in a murine model., PMID:40032072
MiR-30b-5p ameliorates experimental autoimmune uveitis by inhibiting the Atg5/Atg12/Becn1 Axis., PMID:40020463
The RNA-binding protein ELAVL1 promotes Beclin1-mediated cellular autophagy and thus endometrial cancer development by affecting LncRNA-neat stability., PMID:40018990
Renal Expression Levels of C5a Receptor and Autophagy-related Beclin-1 and LC3A/B Are Simultaneously Enhanced Under Immunoglobulin Treatment in a Rat Model of Sepsis., PMID:40010959
RORA Regulates Autophagy in Hair Follicle Stem Cells by Upregulating the Expression Level of the Sqstm1 Gene., PMID:40001602
Artemether relieves liver fibrosis by triggering ferroptosis in hepatic stellate cells via DHHC12-mediated S-palmitoylation of the BECN1 protein., PMID:39988062
Matricaria chamomilla L. Ameliorates Asthma by Protecting OVA-Induced Rats and LPS-Induced Human Bronchial Epithelial Cells Through Suppressing Autophagy and Apoptosis., PMID:39949885
The RNA Demethyltransferase FTO Regulates Ferroptosis in Major Depressive Disorder., PMID:39940841
The mechanism of lncRNA PVT1 targeting the miR-30a/Beclin-1 axis to mediate ventricular remodeling in spontaneously hypertensive rats., PMID:39923929
Dima decoction inhibits ulcerative colitis by activating autophagy through modulation of HIF-1α/BNIP3/Beclin-1 signaling pathway., PMID:39923140
Prognostic Utility of Autophagy Marker Beclin1 in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis., PMID:39907919
Fibrinogen degradation products exacerbate alpha-synuclein aggregation by inhibiting autophagy via downregulation of Beclin1 in multiple system atrophy., PMID:39904669
Loss of DDX24 inhibits lung cancer progression by stimulating IKBKG splicing-mediated autophagy., PMID:39897555
Bioinformatics analysis combined with experimental validation reveals the biological role of the ILK gene in prostate cancer., PMID:39890647
For research use only. Not for human or drug use.
