Catalog No.
YHG80101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser66-Thr327
Predicted molecular weight
31.56 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14451
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GRB7, Growth factor receptor-bound protein 7, GRB7 adapter protein, Epidermal growth factor receptor GRB-7, B47
Stemness-Relevant Gene Signature for Chemotherapeutic Response and Prognosis Prediction in Ovarian Cancer., PMID:40182754
Identification and validation of a novel defined stress granule-related gene signature for predicting the prognosis of ovarian cancer via bioinformatics analysis., PMID:39809219
TRIM36 Inhibits the Development of AOM/DSS-Induced Colitis-Associated Colorectal Cancer by Promoting the Ubiquitination and Degradation of GRB7., PMID:39803720
A Comprehensive Pan-Cancer Analysis Reveals GRB7 as a Potential Diagnostic and Prognostic Biomarker., PMID:39742197
Identification and Validation of circDOCK1/miR-138-5p/GRB7 Axis for Promoting Breast Cancer Progression., PMID:39628959
Distinct copy number signatures between residual benign and transformed areas of carcinoma ex pleomorphic adenoma., PMID:39384827
GRB7-mediated enhancement of cell malignant characteristics induced by Helicobacter pylori infection., PMID:39360313
Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism., PMID:39343875
GRB7 Plays a Vital Role in Promoting the Progression and Mediating Immune Evasion of Ovarian Cancer., PMID:39204147
TCF12-regulated GRB7 facilitates the HER2+ breast cancer progression by activating Notch1 signaling pathway., PMID:39113057
Unravelling the molecular landscape of endometrial cancer subtypes: insights from multiomics analysis., PMID:38775562
Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females., PMID:38578949
Differential Gene Regulatory Network Analysis between Azacitidine-Sensitive and -Resistant Cell Lines., PMID:38542276
Grb7 knockout mice develop normally but litters born to knockout females fail to thrive., PMID:38140940
GRB7 plays a promoting role in the progression of gastric cancer., PMID:38129809
Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways., PMID:38036593
Functional analysis of a putative HER2-associated expressed enhancer, Her2-Enhancer1, in breast cancer cells., PMID:37945744
Detecting Human Epidermal Growth Factor Receptor 2 (HER2) Amplification: Proof of Concept of an Alternative Approach., PMID:37809181
Using Surface Plasmon Resonance to Study SH2 Domain-Peptide Interactions., PMID:37668975
Chromosome instability region analysis and identification of the driver genes of the epithelial ovarian cancer cell lines A2780 and SKOV3., PMID:37525498
Prognostic value of ALK overexpression and molecular abnormalities in high-grade serous ovarian carcinoma., PMID:37522200
Whole-exome sequencing in moyamoya patients of Northern-European origin identifies gene variants involved in Nitric Oxide metabolism: A pilot study., PMID:37383439
Follicular cells protect Xenopus oocyte from abnormal maturation via integrin signaling downregulation and O-GlcNAcylation control., PMID:37354972
GRB10 is a novel factor associated with gastric cancer proliferation and prognosis., PMID:37179120
ERBB family fusions are recurrent and actionable oncogenic targets across cancer types., PMID:37168365
Long range inter-chromosomal interaction of Oct4 distal enhancer loci regulates ESCs pluripotency., PMID:36781845
Astragalus propinquus schischkin and Salvia miltiorrhiza bunge promote angiogenesis to treat myocardial ischemia via Ang-1/Tie-2/FAK pathway., PMID:36699092
Up-regulated GRB7 protein in gastric cancer cells correlates with clinical properties and increases proliferation and stem cell properties., PMID:36686796
Association of genetic ancestry with HER2, GRB7 AND estrogen receptor expression among Colombian women with breast cancer., PMID:36620598
Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability., PMID:35625882
circCDYL2 promotes trastuzumab resistance via sustaining HER2 downstream signaling in breast cancer., PMID:34980129
Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells., PMID:34783299
Gene expression analysis of invasive breast carcinoma yields differential patterns in luminal subtypes of breast cancer., PMID:34517157
Ovarian cycle stage critically affects 21-gene recurrence scores in Mmtv-Pymt mouse mammary tumours., PMID:34174867
Aquaporin-1 facilitates proliferation and invasion of gastric cancer cells via GRB7-mediated ERK and Ras activation., PMID:33209198
Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway., PMID:33162827
Human papillomavirus-positivity is associated with EREG down-regulation and promoter hypermethylation in head and neck squamous cell carcinoma., PMID:33007298
GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma., PMID:32737994
The prognostic significance of GRB7 protein expression and localization in human breast and ovarian cancers., PMID:32595827
Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling., PMID:32577949
Grb7-derived calmodulin-binding peptides inhibit proliferation, migration and invasiveness of tumor cells while they enhance attachment to the substrate., PMID:32420488
Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain., PMID:32360748
Direct Interaction between Calmodulin and the Grb7 RA-PH Domain., PMID:32079204
The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis., PMID:31991573
MicroRNA-374a-5p promotes metastasis of colorectal cancer by targeting GRB7., PMID:31985182
Phase II Feasibility and Biomarker Study of Neoadjuvant Trastuzumab and Pertuzumab With Chemoradiotherapy for Resectable Human Epidermal Growth Factor Receptor 2-Positive Esophageal Adenocarcinoma: TRAP Study., PMID:31809243
Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression., PMID:31740718
Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity., PMID:31627265
Characterization of the full-length human Grb7 protein and a phosphorylation representative mutant., PMID:31353673
Key candidate genes associated with BRAFV600E in papillary thyroid carcinoma on microarray analysis., PMID:31161615
For research use only. Not for human or drug use.
