Catalog No.
YHG77701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu17-Lys259
Predicted molecular weight
30.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14315
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FLN-C, FLNC, Gamma-filamin, ABP-L, Filamin-C, FLN2, FLNc, ABP-280-like protein, Filamin-2, ABPL, Actin-binding-like protein
Selenium alleviates cadmium-induced Golgi stress via HSPB7/GM130/CX-43 axis in the heart of sheep., PMID:40490057
A genome-wide base-editing screen uncovers a pivotal role of paxillin δ ubiquitination in influenza virus infection., PMID:40434888
Immunotyping of thyroid cancer for clinical outcomes and implications., PMID:40418400
Evaluation of aggrephagy markers in myofibrillar myopathies., PMID:40413523
Differential Genes Analysis and Validation of Disulfideptosis in Rat Myocardial Ischemia-Reperfusion Injury Model., PMID:40323799
Filamin C dimerisation is regulated by HSPB7., PMID:40312381
Modulation of Gene Expression by Substrate Stiffness via Ubiquitination of Histone H2B by Ubiquitin-Conjugating Enzyme E2A/B., PMID:40290990
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum., PMID:40195560
Whole exome sequencing of 80 cases of sporadic mitral valve prolapse reveals novel disease-associated genes and variants in a Southern Chinese population., PMID:40131712
Protein Disulfide Isomerase Involvement in Dilated Cardiomyopathy Caused by Filamin C Deficiency in Male Mice., PMID:40099936
Comprehensive identification of hub mRNAs and lncRNAs in colorectal cancer using galaxy: an in silico transcriptome analysis., PMID:40056245
Full-length transcriptome analysis of a bloom-forming dinoflagellate Scrippsiella acuminata (Dinophyceae)., PMID:40016213
Mutations in Filamin C Associated with Both Alleles Do Not Affect the Functioning of Mice Cardiac Muscles., PMID:40003875
Frequent lncRNA-derived fusions in pediatric neuroblastoma identified by LncFusion : potential biomarker and therapeutic implications., PMID:39974126
Mutational and clinical spectrum of myofibrillar myopathy in one center from China., PMID:39973468
Arrhythmic Risk Stratification of Carriers of Filamin C Truncating Variants., PMID:39937464
Sudden cardiac death, arrhythmogenic cardiomyopathy and intercalated disc pathology due to reduced filamin C protein levels: a matter of life and death., PMID:39895064
Case Report: Filamin C gene mutation associated with restrictive cardiomyopathy leading to heart transplantation., PMID:39764157
Fructo-Oligosaccharides Enhance the Expression of Genes Related to Focal Adhesion- and Inflammation-Pathways in Small Intestinal Absorptive Caco-2 Cells., PMID:39756968
Explorations of novel MDR-related hub genes and the potential roles TRIM9 played in drug-resistant hepatocellular carcinoma., PMID:39706432
Identification of disease-specific extracellular vesicle-associated plasma protein biomarkers for Duchenne Muscular Dystrophy and Facioscapulohumeral Muscular Dystrophy., PMID:39649602
S6K/FLNC/ITGβ3 signaling pathway regulates osteoclastogenesis and the inhibition of osteoclastogenesis by columbianadin., PMID:39612888
Electrophysiological Phenotype-Genotype Study of Sustained Monomorphic Ventricular Tachycardia in Inherited, High Arrhythmic Risk, Left Ventricular Cardiomyopathy., PMID:39611258
Protein phosphatase-1 regulates the binding of filamin C to FILIP1 in cultured skeletal muscle cells under mechanical stress., PMID:39521905
Novel FLNC variants in pediatric cardiomyopathy: an insight into disease mechanisms., PMID:39472949
Role of Filamin C in Muscle Cells., PMID:39418514
Full-Length Transcriptome Construction and Systematic Characterization of Virulence Factor-Associated Isoforms in Vairimorpha (Nosema) Ceranae., PMID:39336702
Distinct molecular features of FLNC mutations, associated with different clinical phenotypes., PMID:39315490
Combination of FLNC and JUP variants causing arrhythmogenic cardiomyopathy in an Iranian family with different clinical features., PMID:39180012
SMRT sequencing of a full-length transcriptome reveals cold induced alternative splicing in Vitis amurensis root., PMID:38917739
A Comprehensive Analysis of Non-Desmosomal Rare Genetic Variants in Arrhythmogenic Cardiomyopathy: Integrating in Padua Cohort Literature-Derived Data., PMID:38892455
Identification of key genes for triacylglycerol biosynthesis and storage in herbaceous peony (Paeonia lactifolra Pall.) seeds based on full-length transcriptome., PMID:38877407
Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias., PMID:38761081
Phenotype and Clinical Outcomes in Desmin-Related Arrhythmogenic Cardiomyopathy., PMID:38727660
Filamin C-Associated Nemaline Myopathy., PMID:38657199
Dynamic transcriptome profiles of skeletal muscle growth and development in Shaziling and Yorkshire pigs using RNA-sequencing., PMID:38647104
Generation of a pluripotent stem cell line (UMGi270-A) and a corresponding CRISPR/Cas9 modified isogenic control (UMGi270-A-1) from a patient with sudden onset dilated cardiomyopathy harboring a FLNC p.R2187P mutation., PMID:38583294
Filamin C (FLNC) truncating mutation in a fatal arrhythmogenic left ventricular cardiomyopathy (ALVC)., PMID:38547641
Defective Biomechanics and Pharmacological Rescue of Human Cardiomyocytes with Filamin C Truncations., PMID:38474188
The FLNC Ala1186Val Variant Linked to Cytoplasmic Body Myopathy and Cardiomyopathy Causes Protein Instability., PMID:38397924
Variable clinical expression of a novel FLNC truncating variant in a large family., PMID:38360096
Filamin C Deficiency Impairs Sarcomere Stability and Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes., PMID:38334670
Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer., PMID:38324167
Generation of two hiPSCs lines of two patients carrying truncating mutations in the dimerization domain of filamin C., PMID:38309149
Comparison of differentially expressed genes in longissimus dorsi muscle of Diannan small ears, Wujin and landrace pigs using RNA-seq., PMID:38249550
Integrative analysis identifies gene signatures mediating the effect of DNA methylation on asthma severity and lung function., PMID:38245772
Anti-tumor target screening of sea cucumber saponin Frondoside A: a bioinformatics and molecular docking analysis., PMID:38144520
A case series of patients with filamin-C truncating variants attending a specialized cardiac genetic clinic., PMID:38116480
A child with dilated cardiomyopathy and homozygous splice site variant in FLNC gene., PMID:38077956
Interaction of the C-terminal immunoglobulin-like domains (Ig 22-24) of filamin C with human small heat shock proteins., PMID:38016530
For research use only. Not for human or drug use.
