Catalog No.
YHG72101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala90-Ile250
Predicted molecular weight
20.37 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14145
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
INrf2, INRF2, KLHL19, KEAP1, KIAA0132, Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, Kelch-like protein 19
Design of spiro-heterocyclic substituted diaminonaphthalene Keap1-Nrf2 protein-protein interaction inhibitors as novel anti-depressant agents., PMID:40513368
Lachnospiraceae bacterium alleviates alcohol-associated liver disease by enhancing N-acetyl-glutamic acid levels and inhibiting ferroptosis through the KEAP1-NRF2 pathway., PMID:40511521
Potential of rutin from Rhizophora mucronata leaves as a Inhibitor of Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2 related factor 2 Keap1/Nrf2): An in silico study for Alzheimer's therapy., PMID:40510902
AS-IV Attenuates Oxidative Stress-Induced Apoptosis in Zebrafish via Modulation of the AKT/NRF2/HO-1/Caspase-3 Signaling Axis., PMID:40509241
Suk-SaiYasna Remedy, a Traditional Thai Medicine, Mitigates Stress-Induced Cognitive Impairment via Keap1-Nrf2 Pathway., PMID:40508195
ADSC exosomes improve high glucose induced fibroblast oxidative stress injury and accelerate DFU wound healing via regulating Keap1/Nrf2 axis., PMID:40505843
Pueraria lobata-derived peptides hold promise as a novel antioxidant source by mitigating ethanol-induced oxidative stress in HepG2 cells through regulating the Keap1/Nrf2 pathway., PMID:40505314
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction., PMID:40504949
Computational design of diverse nuclear factor erythroid 2 activators with cellular antioxidative activity., PMID:40502689
FUNCTIONAL ANALYSIS OF BIPARTITE NRF2 ACTIVATORS THAT OVERCOME FEEDBACK REGULATION FOR AGE-RELATED CHRONIC DISEASES., PMID:40501562
Investigating the impact of camel whey protein hydrolysate on cyp1a1 and keap1/nrf2 expression in hypoxic stress-affected liver tissue of Oreochromis niloticus., PMID:40493086
Linking oxidative stress biomarkers to disease progression and antioxidant therapy in hypertension and diabetes mellitus., PMID:40492113
Role of nuclear factor erythroid 2-related factor 2 in negative pressure wound therapy for diabetic foot ulcers., PMID:40487630
Purification, identification, and mechanism of action of novel antioxidant peptides from quinoa (Chenopodium quinoa wild.) protein hydrolysate., PMID:40482480
Thioredoxin-interacting protein: an emerging target for Alzheimer's disease., PMID:40480363
Research progress on Nrf2 intervention in the treatment of diabetic retinopathy., PMID:40469432
Competitive Binding of Pseudomonas aeruginosa to Kelch-Like ECH-Associated Protein 1 Inhibits Nuclear Factor Erythroid 2-Related Factor 2 Ubiquitination and Suppresses Ferroptosis in Macrophages., PMID:40468416
Screening of enzymes for bi-functional whey protein hydrolysates: virtual enzymolysis, fragmentomics, and molecular docking in silico., PMID:40467217
The essential oil from the rhizomes of Stahlianthus involucratus attenuates the progression of vascular aging and atherosclerosis by regulating Nrf2-mediated mitochondrial quality., PMID:40463900
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1., PMID:40456322
CB5712809, a novel Keap1 inhibitor upregulates SQSTM1/p62 mediated Nrf2 activation to induce cell death in colon cancer cells., PMID:40451905
Anti-inflammatory Function of Ozonated Ethyl Ester of Unsaturated Fatty Acids., PMID:40451818
Involvement of the PINK1/Parkin signaling pathway in 4-vinylcyclohexene diepoxide-induced ovary toxicity in rats., PMID:40451534
Tectorigenin alleviates irinotecan-induced intestinal inflammation by activating the Nrf2/Keap1 pathway and synergistically enhances the anti-colon cancer efficacy of irinotecan., PMID:40449752
The Single and Combined Effects of Decabromodiphenyl Ethane and Mixed Microplastics on Male Mice Reproductive Toxicity., PMID:40448585
Gastrodia elata polysaccharide alleviates depression via gut microbiota modulation and Keap1-Nrf2/BDNF-TrkB pathway activation., PMID:40447013
Hepatoprotective Activity of Prunus laurocerasus Fruit Extract Against 5-FU-Induced Liver Injury and LC-MS/MS Profiling., PMID:40446131
Study of the ameliorative effect of β-Bisabolene on ischemic stroke via COX-2 with the Keap1/Nrf2 and MAPK pathways., PMID:40441590
Bioactive ROS-responsive nanotherapeutics attenuate intermittent hypoxia-induced cognitive impairment via NRF2/KEAP1/HO-1 signaling., PMID:40436344
Potential applications of components of aged garlic extract in mitigating pro-inflammatory gene expression linked to human diseases (Review)., PMID:40432842
Icariin Ameliorates Cyclophosphamide-Induced Renal Encephalopathy by Modulating the NF-κB and Keap1-Nrf2 Signaling Pathways., PMID:40429978
Stachydrine from Natural Foods Alleviates Hyperuricemia by Modulating Renal Urate Transporters and Suppressing Mitochondrial Oxidative Stress., PMID:40428497
Bioinformatics-Assisted Discovery of Antioxidant Cyclic Peptides from Corn Gluten Meal., PMID:40428489
Antioxidant Peptides from the Fruit Source of the Oil Crop Litsea cubeba Ameliorate FFA-Induced Oxidative Stress Injury: Based on Nrf2/Keap1 Pathway and Molecular Dynamics Simulations., PMID:40428488
Anti-Inflammasome Effect of Impressic Acid on Diesel Exhaust Particulate Matter-Induced NLRP1 Inflammasome via the Keap1/p62/Nrf2-Signaling Pathway in Keratinocytes., PMID:40427491
Intestinal Microbiota and Gene Expression Alterations in Chinese Mitten Crab (Eriocheir sinensis) Under Deltamethrin Exposure., PMID:40427392
MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3., PMID:40425777
Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2-Related Factor 2 Function in Leukemia and Other Cancers., PMID:40422216
Yellow mealworm (Tenebrio molitor) meal in diets of grass carp (Ctenopharyngodon idellus): Effects on growth performance, antioxidant capacity, immunity, intestinal morphology, and intestinal microbiota., PMID:40416717
Taohong Siwu Decoction modulates glutathione metabolism to suppress hepatocyte ferroptosis and demonstrates anti-fibrotic effects in the liver., PMID:40414577
Alleviation of LPS-induced oxidative stress and inflammation by lesbicoumestan (7) via the increase of Nrf2 expression in mouse Kupffer cells., PMID:40414571
Timosaponin B-II suppresses gastric cancer cell proliferation and induces apoptosis via the Nrf2/miR-455-3p/KLF6 pathway., PMID:40410440
Sanghuangporus vaninii polysaccharides alleviates the effects of chlorpyrifos exposure on mouse liver: role of the gut- liver axis., PMID:40409648
Effect of Dietary Protein and Lipid Level on Growth, Antioxidant, and Gene Expression of Juvenile Parabramis pekinensis., PMID:40406057
PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma., PMID:40405713
Proteomic analysis reveals proteins and pathways associated with the effects of Hippophae rhamnoides L. total flavonoids on ameliorating excessive erythropoiesis in high-altitude polycythemia mice., PMID:40403894
Neoadjuvant PD-1 and PD-L1 Blockade With Chemotherapy for Borderline Resectable and Unresectable Stage III Non-Small Cell Lung Cancer., PMID:40402502
Cyclic peptide structure prediction and design using AlphaFold2., PMID:40399308
Genetic predictors of longevity and survival in cellular homeostasis genes: A case-control study., PMID:40398646
A redox-independent stress response mediated by phase-separated SQSTM1/p62., PMID:40395541
For research use only. Not for human or drug use.
