Catalog No.
YHG71201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys275-Val533
Predicted molecular weight
31.27 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14126
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5
An energy metabolism-related signature relevant to the tumor immune microenvironment in HNSCC., PMID:40383838
DSG2 attenuates gemcitabine efficacy through PTX3 in lung adenocarcinoma., PMID:40316058
Genomic and molecular evidence that the lncRNA DSP-AS1 modulates Desmoplakin expression., PMID:40236443
Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy., PMID:40139877
Natural History and Clinical Outcomes of Patients With DSG2/DSC2 Variant-Related Arrhythmogenic Right Ventricular Cardiomyopathy., PMID:40123482
Case report: Severe arrhythmogenic cardiomyopathy in a young girl with compound heterozygous DSG2 and MYBPC3 variants with a 6-year follow-up., PMID:40115818
Generation of the human iPSC line UNIPDi006-A from a patient with arrhythmogenic cardiomyopathy carrying the DSG2 c.1672C > T pathogenic variant., PMID:40106965
SFRP4 Knockdown Attenuates Dsg2-Deficient Arrhythmogenic Cardiomyopathy by Down-Regulating TGF-β and Smad3., PMID:40019607
Identification of DNA Methylation Differences in Pituitary Tissues of Sichuan White Geese Using Whole-Genome Bisulfite Sequencing (WGBS)., PMID:40001922
Exploring Molecular Alterations in Breast Cancer Among Indian Women Using Label-Free Quantitative Serum Proteomics., PMID:39990193
Predicted Risk of Ventricular Arrhythmias in a Genome-First Population With Genetic Risk for Arrhythmogenic Right Ventricular Cardiomyopathy., PMID:39989366
Coexistence of cardiac sarcoidosis and arrhythmogenic cardiomyopathy-associated genetic variants: a multicentre case-control study., PMID:39837597
Desmoglein-2 was a novel cancer-associated fibroblasts-related biomarker for oral squamous cell carcinoma., PMID:39833796
Proximity Labeling and Genetic Screening Reveal that DSG2 is a Counter Receptor of Siglec-9 and Suppresses Macrophage Phagocytosis., PMID:39813162
Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy., PMID:39763850
ALCAM is an entry factor for severe community acquired Pneumonia-associated Human adenovirus species B., PMID:39738070
Electrophysiological Phenotype-Genotype Study of Sustained Monomorphic Ventricular Tachycardia in Inherited, High Arrhythmic Risk, Left Ventricular Cardiomyopathy., PMID:39611258
Prevalence and Correlates of Anti-DSG2 Antibodies in Arrhythmogenic Right Ventricular Cardiomyopathy and Myocarditis: Immunological Insights from a Multicenter Study., PMID:39597880
Prevalence, Penetrance, and Phenotypic Manifestation of Cardiomyopathy-Associated Genetic Variants in the General Population: Insights from a Mayo Clinic Biobank Study., PMID:39387793
Case report: Additional variants induced sudden cardiac death among pediatric ACM with DSG2 homozygous mutant genotype: a report of three cases., PMID:39253717
Hyperactivation of ATF4/TGF-β1 signaling contributes to the progressive cardiac fibrosis in Arrhythmogenic cardiomyopathy caused by DSG2 Variant., PMID:39227800
Up-regulated DSG2 promotes tumor growth and reduces immune infiltration in cervical cancer., PMID:39226803
Expression and prognosis of DSG-2, CXADR, CD46 in head and neck squamous cell carcinoma., PMID:39173463
Prognostic potential of PRMT5 and DSG2 proteins in pre-malignant cervical lesions., PMID:39166520
Enhanced desmosome assembly driven by acquired high-level desmoglein-2 promotes phenotypic plasticity and endocrine resistance in ER+ breast cancer., PMID:39154704
Cardiac sympathetic neurons are additional cells affected in genetically determined arrhythmogenic cardiomyopathy., PMID:39141822
Machine learning and 4D-LFQ quantitative proteomic analysis explore the molecular mechanism of kidney stone formation., PMID:39114033
Adhesion of pancreatic tumor cell clusters by desmosomal molecules enhances early liver metastases formation., PMID:39107343
Arrhythmogenic cardiomyopathy-related cadherin variants affect desmosomal binding kinetics., PMID:39079569
High-Fat Diet Augments Myocardial Inflammation and Cardiac Dysfunction in Arrhythmogenic Cardiomyopathy., PMID:38999835
Dissecting Crucial Gene Markers Involved in HPV-Associated Oropharyngeal Squamous Cell Carcinoma from RNA-Sequencing Data through Explainable Artificial Intelligence., PMID:38940026
Animal Models and Molecular Pathogenesis of Arrhythmogenic Cardiomyopathy Associated with Pathogenic Variants in Intercalated Disc Genes., PMID:38892395
Comprehensive landscape of junctional genes and their association with overall survival of patients with lung adenocarcinoma., PMID:38841188
Desmosomal Hyper-Adhesion Affects Direct Inhibition of Desmoglein Interactions in Pemphigus., PMID:38677661
Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer., PMID:38671389
Molecular genetic screening after non-ischaemic sudden cardiac arrest and no overt cardiomyopathy in real life: A major tool for the aetiological diagnostic work-up., PMID:38670870
Dsg2 ectodomain organization increases throughout desmosome assembly., PMID:38566311
CD109 drives pro-tumorigenic cell properties in human non-small cell lung cancer through interaction with desmoglein-2., PMID:38562713
A Retrospective View of the Triple-Negative Breast Cancer Microenvironment: Novel Markers, Interactions, and Mechanisms of Tumor-Associated Components Using Public Single-Cell RNA-Seq Datasets., PMID:38539508
Extracellular Vesicles as Novel Diagnostic and Therapeutic Agents for Non-Melanoma Skin Cancer: A Systematic Review., PMID:38473864
Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy., PMID:38463975
Serine/threonine-protein kinase D2-mediated phosphorylation of DSG2 threonine 730 promotes esophageal squamous cell carcinoma progression., PMID:38411280
The role of desmoglein-2 in kidney disease., PMID:38395410
Ser194Leu DSG2 mutation, associated with arrhythmogenic left ventricular cardiomyopathy and ventricular tachycardia., PMID:38375917
Desmoglein-2 Affects Vascular Function in Moyamoya Disease by Interacting with MMP-9 and Influencing PI3K Signaling., PMID:38326520
JNK inhibition enhances cell-cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes., PMID:38227055
Serum proteomics reveals a tolerant immune phenotype across multiple pathogen taxa in wild vampire bats., PMID:38193073
Desmoglein-2 as a cancer modulator: friend or foe?, PMID:38188287
Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathy., PMID:38185631
For research use only. Not for human or drug use.
