Catalog No.
YHG70601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro447-Ile675
Predicted molecular weight
28.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14114
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LRP8, LRP-8, Low-density lipoprotein receptor-related protein 8, APOER2, Apolipoprotein E receptor 2
Reelin-LRP8 signaling mediates brain dissemination of breast cancer cells via abluminal migration., PMID:40506610
Identification of candidate genes affecting egg weight trait of Putian Black duck based on whole genome resequencing., PMID:40380810
LRP8 Regulates Lipid Metabolism to Stimulate Malignant Progression and Cisplatin Resistance in Bladder Cancer., PMID:40372166
Structural impact of GSR and LRP8 gene polymorphisms on protein function and their role in racing performance of homing pigeons., PMID:40246119
LRP8-dependent cholesterol metabolism modulates mTORC1 signaling and apoptotic pathways in multiple myeloma., PMID:40199866
Development of a prognostic model based on the ceRNA network in Triple-Negative Breast cancer., PMID:40034665
Physical and functional interactions between LDLR family members and CXCR4 in breast cancer., PMID:40022442
Effect of PCSK9 Inhibitors on Regulators of Lipoprotein Homeostasis, Inflammation and Coagulation., PMID:40002707
LRP8 inhibits bladder cancer cell ferroptosis by activating the Wnt/β-catenin-SCD1 positive feedback loop., PMID:39989004
KAT8 catalyzes the acetylation of SEPP1 at lysine 247/249 and modulates the activity of CD8+ T cells via LRP8 to promote anti-tumor immunity in pancreatic cancer., PMID:39972392
Deletion of an evolutionarily conserved TAD boundary impacts spermatogenesis in mice†., PMID:39903672
Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction., PMID:39892386
A bioinformatic approach to characterize the vitellogenin receptor and the low density lipoprotein receptor superfamily in the newt Cynops orientalis., PMID:39870874
Transcriptome analyses reveal molecular mechanisms of novel compound heterozygous ACO2 variants causing infantile cerebellar retinal degeneration., PMID:39600307
PCSK9 inhibitor protects against myocardial ischemia-reperfusion injury via inhibiting LRP8/GPX4-mediated ferroptosis., PMID:39422930
Single-cell RNA sequencing of pediatric Hodgkin lymphoma to study the inhibition of T cell subtypes., PMID:39233904
Identifying novel proteins underlying bipolar disorder via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data., PMID:39191728
OCRL1 Deficiency Affects the Intracellular Traffic of ApoER2 and Impairs Reelin-Induced Responses., PMID:39062513
Deletion of an evolutionarily conserved TAD boundary compromises spermatogenesis in mice., PMID:39026739
Expression levels of the selenium-uptake receptor LRP8, the antioxidant selenoprotein GPX1 and steroidogenic enzymes correlate in granulosa cells., PMID:38990713
Cerebrospinal Fluid Proteomics Identifies Potential Biomarkers for Early-Onset Alzheimer's Disease., PMID:38848183
Uncovering novel drug targets for bipolar disorder: a Mendelian randomization analysis of brain, cerebrospinal fluid, and plasma proteomes., PMID:38720515
Spon1+ inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signaling., PMID:38716730
Detection and Analysis of Genes Affecting the Number of Thoracic Vertebrae in Licha Black Pigs., PMID:38674411
Lrp8 knockout mice fed a selenium-replete diet display subtle deficits in their spatial learning and memory function., PMID:38661671
Enhanced LRP8 expression induced by Helicobacter pylori drives gastric cancer progression by facilitating β-Catenin nuclear translocation., PMID:38609049
Low-density lipoprotein receptor-related protein 5/6 promotes endometrial cancer progression and cancer cell immune escape., PMID:38528715
MiR-378a-5p exerts a radiosensitizing effect on CRC through LRP8/β-catenin axis., PMID:38389136
Single-cell analysis with childhood and adult systemic lupus erythematosus., PMID:38347676
LRP8 promotes tumorigenesis in ovarian cancer through inhibiting p53 signaling., PMID:38263609
MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells., PMID:38182558
"Alphabet" Selenoproteins: Their Characteristics and Physiological Roles., PMID:37958974
[Tau Protein Induces Aberrant Alternative Splicing Changes in PS19 Transgenic Mice]., PMID:37866941
Therapeutic targeting of the TPX2/TTK network in colorectal cancer., PMID:37770979
Important roles of Hif1a in maternal or adult BPA exposure induced pancreatic injuries., PMID:37460698
LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma., PMID:37435859
Different sensitivity to diet-induced hyperinsulinemia and hyperglycemia between mice with global or bone marrow-specific apoE receptor-2 deficiency., PMID:37212552
Apolipoprotein C3 facilitates internalization of cationic lipid nanoparticles into bone marrow-derived mouse mast cells., PMID:36624108
Interaction networks and pathway analysis of genetic resistance to gastrointestinal nematodes in sheep., PMID:36609787
Identification of Two CDK5R1-Related Subtypes and Characterization of Immune Infiltrates in Alzheimer's Disease Based on an Integrated Bioinformatics Analysis., PMID:36561735
miR-1322 protects against the myocardial ischemia via LRP8/PI3K/AKT pathway., PMID:36446154
Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells., PMID:36343682
Tumor Apolipoprotein E is a key checkpoint blocking anti-tumor immunity in mouse melanoma., PMID:36341364
Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma., PMID:36273157
Relationship between RELN signaling pathway genes and language development of autism based on a cluster model., PMID:36039581
Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration., PMID:36012187
Reduced serum high-density lipoprotein cholesterol levels and aberrantly expressed cholesterol metabolism genes in colorectal cancer., PMID:35663062
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability., PMID:35637349
Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations., PMID:35449212
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension., PMID:35257044
For research use only. Not for human or drug use.
