Catalog No.
YHG69201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu142
Predicted molecular weight
18.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14019
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Coactosin-like protein, COTL1, CLP
Proteomics analysis and immune profiling reveal regulators of PD-L1 in oesophageal squamous cell carcinoma., PMID:40490504
Coactosin-like F-actin binding protein (Cotl1) plays a key role in adipocyte differentiation and obesity., PMID:40246959
Knockdown of BATF alleviates lung injury in septic neonates through transcriptional regulation of COTL1., PMID:39720271
Development and validation of a prognostic prediction model for endometrial cancer based on CD8+ T cell infiltration-related genes., PMID:39654198
Insights into preeclampsia: a bioinformatics approach to deciphering genetic and immune contributions., PMID:39165753
Coactosin-like protein 1 regulates integrity and repair of model intestinal epithelial barriers via actin binding dependent and independent mechanisms., PMID:39040043
Machine learning algorithms integrate bulk and single-cell RNA data to unveil oxidative stress following intracerebral hemorrhage., PMID:38865753
Potential marker genes for chronic obstructive pulmonary disease revealed based on single-cell sequencing and Mendelian randomization analysis., PMID:38787375
A novel imprinted locus on bovine chromosome 18 homologous with human chromosome 16q24.1., PMID:38546894
Coactosin-Like Protein 1 (COTL1) Could Be an Immunological and Prognostic Biomarker: From Pan-Cancer Analysis to Low-Grade Glioma Validation., PMID:38523681
Role of ALOX5 in non-small cell lung cancer: A potential therapeutic target associated with immune cell infiltration., PMID:37164914
Coactosin-Like Protein in Breast Carcinoma: Friend or Foe?, PMID:35873386
Plasma Proteomic Analysis Identified Proteins Associated with Faulty Neutrophils Functionality in Decompensated Cirrhosis Patients with Sepsis., PMID:35681439
Proteomic profiling reveals a distinctive molecular signature for critically ill COVID-19 patients compared with asthma and chronic obstructive pulmonary disease., PMID:35017110
Coactosin Promotes F-Actin Protrusion in Growth Cones Under Cofilin-Related Signaling Pathway., PMID:34235144
The Wdr1-LIMK-Cofilin Axis Controls B Cell Antigen Receptor-Induced Actin Remodeling and Signaling at the Immune Synapse., PMID:33928084
Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study., PMID:33912629
Long noncoding RNA Cfast regulates cardiac fibrosis., PMID:33473324
Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium., PMID:33440265
A 9 mRNAs-based diagnostic signature for rheumatoid arthritis by integrating bioinformatic analysis and machine-learning., PMID:33430905
Coactosin-Like Protein (COTL1) Promotes Glioblastoma (GBM) Growth in vitro and in vivo., PMID:33154670
Downregulation of microRNA-30c-5p was responsible for cell migration and tumor metastasis via COTL1-mediated microfilament arrangement in breast cancer., PMID:32775265
RETRACTED: Sevoflurane up-regulates microRNA-204 to ameliorate myocardial ischemia/reperfusion injury in mice by suppressing Cotl1., PMID:32730836
Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets., PMID:31582545
Further studies about Coactosin-like protein-1 affecting the migration of mouse neocortical neurons., PMID:30128637
Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins., PMID:29954413
Exposure to cigarette smoke extract and lipopolysaccharide modifies cytoskeleton organization in bronchial epithelial cells., PMID:29199880
Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling., PMID:28925397
Coactosin-like protein 1 inhibits neuronal migration during mouse corticogenesis., PMID:28385010
Does an increased body mass index affect endometrial gene expression patterns in infertile patients? A functional genomics analysis., PMID:27919438
Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression., PMID:27893417
The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length Counterpart., PMID:26173130
EhCoactosin stabilizes actin filaments in the protist parasite Entamoeba histolytica., PMID:25210743
Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis., PMID:25034252
Comparative proteome analysis of peripheral neutrophils from sulfur mustard-exposed and COPD patients., PMID:24852194
Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse., PMID:24454796
Differential expression of PAI-RBP1, C1orf142, and COTL1 in non-small cell lung cancer cell lines with different tumor metastatic potential., PMID:22373659
Proteomic analysis of human small cell lung cancer tissues: up-regulation of coactosin-like protein-1., PMID:21047053
Active chromatin marks are retained on X chromosomes lacking gene or repeat silencing despite XIST/Xist expression in somatic cell hybrids., PMID:20520737
Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102., PMID:19807693
NMR solution structures of actin depolymerizing factor homology domains., PMID:19768801
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo., PMID:19579006
Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders., PMID:19307756
The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression., PMID:18783612
Effect of protein structure on laccase-catalyzed protein oligomerization., PMID:17090138
Binding model of human coactosin-like protein with filament actin revealed by mutagenesis., PMID:17070122
Differentially expressed transcripts in shell glands from low and high egg production strains of chickens using cDNA microarrays., PMID:17034964
Towards unambiguous assignment of methyl-containing residues by double and triple sensitivity-enhanced HCCmHm-TOCSY experiments., PMID:16964533
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production., PMID:16924104
NMR structure of human coactosin-like protein., PMID:15754059
For research use only. Not for human or drug use.
