Catalog No.
YHG67201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys780-Asn1035
Predicted molecular weight
32.17 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13905
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Guanine nucleotide-releasing factor 2, RAPGEF1, GRF2, Protein C3G, CRK SH3-binding GNRP, Rap guanine nucleotide exchange factor 1
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response., PMID:39989399
Identification and Functional Analysis of Ras-Related Associated with Diabetes Gene (rrad) in Edwardsiella piscicida-Resistant Individuals of Japanese Flounder (Paralichthys olivaceus)., PMID:39408905
Development and tissue specific expression of RAPGEF1 (C3G) transcripts having exons encoding disordered segments with predicted regulatory function., PMID:39141165
Platelet C3G: a key player in vesicle exocytosis, spreading and clot retraction., PMID:38345631
New and Old Key Players in Liver Cancer., PMID:38138981
Identification and functional validation of SRC and RAPGEF1 as new direct targets of miR-203, involved in regulation of epidermal homeostasis., PMID:37635193
Transcriptome, proteome and metabolome analysis provide insights on fat deposition and meat quality in pig., PMID:36914311
Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms., PMID:36737758
C3G down-regulation enhances pro-migratory and stemness properties of oval cells by promoting an epithelial-mesenchymal-like process., PMID:36263169
Identity-by-descent analysis of a large Tourette's syndrome pedigree from Costa Rica implicates genes involved in neuronal development and signal transduction., PMID:36224258
Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice., PMID:35502705
Andrographolide suppresses osteoarthritis progression by regulating circ_Rapgef1/miR-383-3p/NLRP3 signaling axis., PMID:35122957
Experimental Characterization of the Interaction between the N-Terminal SH3 Domain of Crkl and C3G., PMID:34947971
Effects of Maternal Nutrition on Female Offspring Weight Gain and Sexual Development., PMID:34887899
Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis., PMID:34685730
C3G Protein, a New Player in Glioblastoma., PMID:34576182
Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells., PMID:33951626
Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation., PMID:33834495
C3G Regulates STAT3, ERK, Adhesion Signaling, and Is Essential for Differentiation of Embryonic Stem Cells., PMID:33624208
C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies., PMID:33553598
Complex formation and reciprocal regulation between GSK3β and C3G., PMID:33450305
Expression of a novel brain specific isoform of C3G is regulated during development., PMID:33139841
C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length., PMID:32371504
Whole exome sequencing identifies multiple novel candidate genes in familial gastroschisis., PMID:32163230
Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis., PMID:32041892
Biological Pathways Leading From ANGPTL8 to Diabetes Mellitus-A Co-expression Network Based Analysis., PMID:30627105
How Rap and its GEFs control liver physiology and cancer development. C3G alterations in human hepatocarcinoma., PMID:30302196
Development and characterization of a novel monoclonal antibody that recognizes an epitope in the central protein interaction domain of RapGEF1 (C3G)., PMID:30143974
A Genome-Wide Association Study of α-Synuclein Levels in Cerebrospinal Fluid., PMID:29959729
C3G promotes a selective release of angiogenic factors from activated mouse platelets to regulate angiogenesis and tumor metastasis., PMID:29340032
Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion., PMID:28273099
C3G shows regulated nucleocytoplasmic exchange and represses histone modifications associated with euchromatin., PMID:28148649
Pathway analysis of bladder cancer genome-wide association study identifies novel pathways involved in bladder cancer development., PMID:27738493
C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development., PMID:27111087
C3G (RapGEF1), a regulator of actin dynamics promotes survival and myogenic differentiation of mouse mesenchymal cells., PMID:26133694
Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways., PMID:24263067
Neutrophil cell surface receptors and their intracellular signal transduction pathways., PMID:23994464
Reciprocal Negative Regulation between the Guanine Nucleotide Exchange Factor C3G and β-Catenin., PMID:23486661
Emerging role of tyrosine phosphatase, TCPTP, in the organelles of the early secretory pathway., PMID:23328081
TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells., PMID:21876762
Analysis of potential biomarkers and modifier genes affecting the clinical course of CLN3 disease., PMID:21863212
Frequent somatic demethylation of RAPGEF1/C3G intronic sequences in gastrointestinal and gynecological cancer., PMID:21399874
Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans., PMID:21283750
Cytoskeletal remodeling by C3G to induce neurite-like extensions and inhibit motility in highly invasive breast carcinoma cells., PMID:21223981
Association between polymorphisms in RAPGEF1, TP53, NRF1 and type 2 diabetes in Chinese Han population., PMID:21146886
F-actin-binding domain of c-Abl regulates localized phosphorylation of C3G: role of C3G in c-Abl-mediated cell death., PMID:20581864
RAPGEF1 gene variants associated with type 2 diabetes in the Korean population., PMID:19297053
Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes., PMID:18678618
C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment., PMID:18506028
C3G regulates the size of the cerebral cortex neural precursor population., PMID:16858399
For research use only. Not for human or drug use.
