Catalog No.
YHG66301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe191-Thr445
Predicted molecular weight
31.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13882
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein-tyrosine kinase 6, BRK, PTK6, Breast tumor kinase, Tyrosine-protein kinase BRK
PTK6 drives HNRNPH1 phase separation to activate autophagy and suppress apoptosis in colorectal cancer., PMID:40103198
Development and validation of a kinase-related gene signature as a novel diagnostic and prognostic model for prostate cancer., PMID:39965532
Investigation of the protective effect of cilostazol on acute lung injury-mediated inflammation and in silico molecular modelling studies of inflammatory signalling pathway: a repurposing study., PMID:39754679
Circular RNAs as a new perspective in the diagnosis and mechanism of Leishmania infections., PMID:39706505
High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study., PMID:39669579
A PROTAC degrader suppresses oncogenic functions of PTK6, inducing apoptosis of breast cancer cells., PMID:39541980
Impaired activation of succinate-induced type 2 immunity and secretory cell production in the small intestines of Ptk6-/- male mice., PMID:39461944
Trifolirhizin targets PTK6 to induce autophagy and exerts antitumor effects in nasopharyngeal carcinoma., PMID:39392221
Circular RNA hsa_circ_0001610 promotes prostate cancer progression by sponging miR-1324 and upregulating PTK6., PMID:39098513
Glucocorticoid receptors orchestrate a convergence of host and cellular stress signals in triple negative breast cancer., PMID:38950871
Comprehensive analysis of autophagy associated genes and immune infiltrates in cervical cancer., PMID:38800011
Kinase activities in pancreatic ductal adenocarcinoma with prognostic and therapeutic avenues., PMID:38650175
Gastric cancer prognosis: unveiling autophagy-related signatures and immune infiltrates., PMID:38617515
PTK6: An emerging biomarker for prognosis and immunotherapeutic response in clear cell renal carcinoma (KIRC)., PMID:38596018
Identification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6., PMID:38573548
MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases., PMID:38457262
Autophagy-related risk signature based on CDNK2A to facilitate survival prediction of patients with endometrial cancer., PMID:38282156
In Silico Screening of Multi-Domain Targeted Inhibitors for PTK6: A Strategy Integrating Drug Repurposing and Consensus Docking., PMID:38256893
Prognostic impact of PTK6 expression in triple negative breast cancer., PMID:37932734
Prognostic model construction and target identification of Si-Wu-Tang against breast cancer., PMID:37876445
Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer., PMID:37509364
Brk/PTK6 and Involucrin Expression May Predict Breast Cancer Cell Responses to Vitamin D3., PMID:37445934
CD147 monoclonal antibody attenuates abdominal aortic aneurysm formation in angiotensin II-Infused apoE-/- mice., PMID:37393837
BRK confers tamoxifen-resistance in breast cancer via regulation of tyrosine phosphorylation of CDK1., PMID:37216999
[Mechanism of Huangjing Qianshi Decoction in treatment of prediabetic mice based on transcriptome sequencing]., PMID:36872274
Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk., PMID:36854171
PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation., PMID:36690663
ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer., PMID:36670069
Long-term exposure to genistein inhibits the proliferation of gallbladder cancer by downregulating the MCM complex., PMID:36546234
Genistein suppresses gallbladder cancer tumorigenesis and progression via downregulating ERBB2 mediated PTK6/AKT/MCM pathway., PMID:36545974
Comprehensive Analysis Reveals PTK6 as a Prognostic Biomarker Involved in the Immunosuppressive Microenvironment in Breast Cancer., PMID:36405012
Protein tyrosine kinase 6 regulates activation of SRC kinase., PMID:36228719
The roles of the tumor suppressor parafibromin in cancer., PMID:36211470
An eleven autophagy-related genes-based prognostic signature for endometrial carcinoma., PMID:36210389
Interference of PTK6/GAB1 signaling inhibits cell proliferation, invasion, and migration of cervical cancer cells., PMID:35894144
Epigenetic Deregulation of Protein Tyrosine Kinase 6 Promotes Carcinogenesis of Oral Squamous Cell Carcinoma., PMID:35562900
FSCN1 Promotes Esophageal Carcinoma Progression Through Downregulating PTK6 via its RNA-Binding Protein Effect., PMID:35401239
Breast Tumour Kinase (Brk/PTK6) Contributes to Breast Tumour Xenograft Growth and Modulates Chemotherapeutic Responses In Vitro., PMID:35327957
Prognostic value of protein tyrosine kinase 6 overexpression in cancers: a meta-analysis., PMID:35227003
Knockdown of microRNA-214-3p Promotes Tumor Growth and Epithelial-Mesenchymal Transition in Prostate Cancer., PMID:34884984
Possible Therapeutic Applications of Targeting STAP Proteins in Cancer., PMID:34853263
Identification and Validation of Autophagy-Related Genes as Potential Biomarkers and Therapeutic Targets in Atrial Fibrillation., PMID:34785936
Mucin Expression and Splicing Determine Novel Subtypes and Patient Mortality in Pancreatic Ductal Adenocarcinoma., PMID:34615717
A Four Autophagy-Related Gene-Based Prognostic Signature for Pancreatic Cancer., PMID:34587439
Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis., PMID:34555678
Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer., PMID:34551797
PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression., PMID:34340703
TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling., PMID:34145060
Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile., PMID:34138566
Prognostic biomarker identification and tumor classification in breast cancer patients by methylation and transcriptome analysis., PMID:34056873
For research use only. Not for human or drug use.
