Catalog No.
EHG63701
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Thr134
Predicted molecular weight
41.57 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13705
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B
Combined rapamycin and mesenchymal stem/stromal cells derived from induced pluripotent stem cells-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva., PMID:40416557
Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3., PMID:40360531
Gel Electrophoretic Detection of Black Market ACE-031., PMID:40312924
Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder., PMID:40144023
ACVR2B polymorphism, Adiponectin, and GDF-15 levels as biomarkers for cachexia in gastrointestinal cancer., PMID:39533028
LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity., PMID:39254854
KIT in oocytes: a key factor for oocyte survival and reproductive lifespan., PMID:39067135
Human Genetics of Defects of Situs., PMID:38884744
Inhibition of activin receptor 2 signalling ameliorates metabolic dysfunction-associated steatotic liver disease in western diet/L-NAME induced cardiometabolic disease., PMID:38705130
Cell communication pathway prognostic model identified detrimental neurodevelopmental pathways in neuroblastoma., PMID:38669760
Multi-organ single-cell transcriptomics of immune cells uncovered organ-specific gene expression and functions., PMID:38538617
iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva., PMID:38500216
Humoral immunoprofiling identifies novel biomarkers and an immune suppressive autoantibody phenotype at the site of disease in pancreatic ductal adenocarcinoma., PMID:38450186
The Activation of the Fibrodysplasia Ossificans Progressiva-Inducing ALK2-R206H Mutant Depends on the Distinct Homo-Oligomerization Patterns of ACVR2B and ACVR2A., PMID:38334613
Targeting myostatin using quercetin as a media supplement to improve myogenesis for cultured meat production: An in silico and in vitro study., PMID:38298827
ACVR1: A Novel Therapeutic Target to Treat Anemia in Myelofibrosis., PMID:38201581
Genetic variants in myostatin and its receptors promote elite athlete status., PMID:38082252
Genome-wide characterization of the TGF-β gene family and their expression in different tissues during tail regeneration in the Schlegel's Japanese gecko Gekko japonicus., PMID:37984573
Identification of Missense Variants Affecting Carcass Traits for Hanwoo Precision Breeding., PMID:37895191
Genome-wide analysis of BMP/GDF family and DAP-seq of YY1 suggest their roles in Cynoglossus semilaevis sexual size dimorphism., PMID:37793513
Expression Levels of the Tnni3k Gene in the Heart Are Highly Associated with Cardiac and Glucose Metabolism-Related Phenotypes and Functional Pathways., PMID:37628941
Bioinformatics Analysis of the Genetic and Epigenetic Alterations of Bone Morphogenetic Protein Receptors in Metastatic Breast Cancer., PMID:37486509
Aberrant expression of bone morphogenetic proteins in the disease progression and metastasis of breast cancer., PMID:37333824
Identification of zona pellucida defects revealed a novel loss-of-function mutation in ZP2 in humans and rats., PMID:37293489
Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway., PMID:36950748
A novel pyroptosis gene expression-based risk score for survival in gastric cancer., PMID:36793271
Circ_0000566 contributes oxygen-glucose deprivation and reoxygenation (OGD/R)-induced human brain microvascular endothelial cell injury via regulating miR-18a-5p/ACVR2B axis., PMID:36781583
The Potential Circular RNAs Biomarker Panel and Regulatory Networks of Parkinson's Disease., PMID:35645729
Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition., PMID:35643319
Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin., PMID:35510530
RNA sequence analysis identified bone morphogenetic protein-2 (BMP2) as a biomarker underlying form deprivation myopia., PMID:35494490
Transcriptome-guided resolution of tumor microenvironment interactions in pheochromocytoma and paraganglioma subtypes., PMID:35088383
The Exploration of Poor Ovarian Response-Related Risk Factors: A Potential Role of Growth Differentiation Factor 8 in Predicting Ovarian Response in IVF-ET Patient., PMID:34630324
Autoantibodies in the diagnosis, prognosis, and prediction of colorectal cancer., PMID:34528528
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs., PMID:34520530
An lncRNA-miRNA-mRNA-ceRNA network regulates intervertebral disc degeneration: A bioinformatics study based on the dataset analysis., PMID:34350836
Association of myostatin deficiency with collagen related disease-umbilical hernia and tippy toe standing in pigs., PMID:34304368
The association between sarcopenia susceptibility and polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans., PMID:34302448
Deficiency of myostatin protects skeletal muscle cells from ischemia reperfusion injury., PMID:34131275
Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis., PMID:34099644
Downregulated in renal carcinoma 1 (DRR1) mediates the differentiation of neural stem cells through transcriptional regulation., PMID:33965500
Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2/Acvr2b competitive receptor-activated Smad pathway., PMID:33838528
Three SNPs within exons of INHA and ACVR2B genes are significantly associated with litter size in Dazu black goats., PMID:33720451
Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic Encephalopathy., PMID:33706404
Gonadal Cycle-Dependent Expression of Genes Encoding Peptide-, Growth Factor-, and Orphan G-Protein-Coupled Receptors in Gonadotropin- Releasing Hormone Neurons of Mice., PMID:33551743
A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities., PMID:33408083
Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A., PMID:33219121
A polymorphism in the cachexia-associated gene INHBA predicts efficacy of regorafenib in patients with refractory metastatic colorectal cancer., PMID:32970737
Enzymatic preparation of Crassostrea oyster peptides and their promoting effect on male hormone production., PMID:32918991
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight., PMID:32900939
For research use only. Not for human or drug use.
