Catalog No.
YHG62601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser32-Ser355
Predicted molecular weight
37.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13641
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
5T4, TPBG, WAIF1, M6P1, 5T4 oncofetal trophoblast glycoprotein, Trophoblast glycoprotein, 5T4 oncofetal antigen, 5T4 oncotrophoblast glycoprotein, Wnt-activated inhibitory factor 1
Proteogenomic analysis of the CALGB 40601 (Alliance) HER2+ breast cancer neoadjuvant trial reveals resistance biomarkers., PMID:40480221
Exploring the Therapeutic Potential of the DOT1L Inhibitor EPZ004777 Using Bioinformatics and Molecular Docking Approaches in Acute Myeloid Leukemia., PMID:40136427
Identification and validation of a novel autoantibody biomarker panel for differential diagnosis of pancreatic ductal adenocarcinoma., PMID:39949781
Proteomic Approach Using DIA-MS Identifies Morphogenesis-Associated Proteins during Cardiac Differentiation of Human iPS Cells., PMID:39829588
In-Depth Examination of TPBG as a New Predictive Indicator for Gastric Cancer., PMID:39823250
ANGPTL4 mediated mesothelial-mesenchymal transition in pulmonary fibrosis: a potential therapeutic target., PMID:39707362
A randomized phase II trial to examine modified vaccinia Ankara-5T4 vaccine in patients with relapsed asymptomatic ovarian cancer (TRIOC)., PMID:38760075
Overexpressed Trophoblast Glycoprotein Contributes to Preeclampsia Development by Inducing Abnormal Trophoblast Migration and Invasion Toward the Uterine Spiral Artery., PMID:38716674
Identification of survival related key genes and long-term survival specific differentially expressed genes related key miRNA network of primary glioblastoma., PMID:38601561
Trophoblast glycoprotein is required for efficient synaptic vesicle exocytosis from retinal rod bipolar cells., PMID:38099150
Quantitative Proteomics for the Development and Manufacturing of Human-Induced Pluripotent Stem Cell-Derived Neural Stem Cells Using Data-Independent Acquisition Mass Spectrometry., PMID:37097202
Parkinson's Disease Gene Biomarkers Screened by the LASSO and SVM Algorithms., PMID:36831718
Immunohistochemical Detection of 5T4 in Renal Cell Carcinoma., PMID:36735485
Inflammation in Preeclampsia: Genetic Biomarkers, Mechanisms, and Therapeutic Strategies., PMID:35880174
Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse., PMID:35551574
LINC00342 induces metastasis of lung adenocarcinoma by targeting miR-15b/TPBG., PMID:35452205
ASN004, A 5T4-targeting scFv-Fc Antibody-Drug Conjugate with High Drug-to-Antibody Ratio, Induces Complete and Durable Tumor Regressions in Preclinical Models., PMID:34045226
LRR-Containing Oncofetal Trophoblast Glycoprotein 5T4 Shapes Neural Circuits in Olfactory and Visual Systems., PMID:33192298
The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis., PMID:32848510
Safety and immunogenicity of novel 5T4 viral vectored vaccination regimens in early stage prostate cancer: a phase I clinical trial., PMID:32591433
Expression and distribution of trophoblast glycoprotein in the mouse retina., PMID:31891182
Preclinical development of T-cell receptor-engineered T-cell therapy targeting the 5T4 tumor antigen on renal cell carcinoma., PMID:31686124
Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope., PMID:31619516
Expression of Oncofetal Antigen 5T4 in Murine Taste Papillae., PMID:31417363
Identification of PKCα-dependent phosphoproteins in mouse retina., PMID:31255707
Role of TPBG (Trophoblast Glycoprotein) Antigen in Human Pericyte Migratory and Angiogenic Activity., PMID:31018661
Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer., PMID:30736848
Combining data from TCGA and GEO databases and reverse transcription quantitative PCR validation to identify gene prognostic markers in lung cancer., PMID:30718962
Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition., PMID:30352801
Expression of 5T4 extracellular domain fusion protein and preparation of anti-5T4 monoclonal antibody with high affinity and internalization efficiency., PMID:29981846
WAIF1 Is a Cell-Surface CTHRC1 Binding Protein Coupling Bone Resorption and Formation., PMID:29624737
The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking., PMID:29549047
The 5T4 oncofetal glycoprotein does not act as a general organizer of the CXCL12 system in cancer cells., PMID:29408206
Preclinical Assessment of CAR T-Cell Therapy Targeting the Tumor Antigen 5T4 in Ovarian Cancer., PMID:29239915
Detecting expression of 5T4 in CTCs and tumor samples from NSCLC patients., PMID:28727782
5T4-specific chimeric antigen receptor modification promotes the immune efficacy of cytokine-induced killer cells against nasopharyngeal carcinoma stem cell-like cells., PMID:28687750
5T4 oncofoetal glycoprotein: an old target for a novel prostate cancer immunotherapy., PMID:28537896
Transethnic genome-wide scan identifies novel Alzheimer's disease loci., PMID:28183528
First-in-human trial of an anti-5T4 antibody-monomethylauristatin conjugate, PF-06263507, in patients with advanced solid tumors., PMID:28070718
5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Squamous Cell Carcinoma., PMID:27780858
5T4 oncofoetal antigen: an attractive target for immune intervention in cancer., PMID:27757559
Biodistribution and Targeting of Anti-5T4 Antibody-Drug Conjugate Using Fluorescence Molecular Tomography., PMID:27466353
Enhanced Antitumor Activity of an Anti-5T4 Antibody-Drug Conjugate in Combination with PI3K/mTOR inhibitors or Taxanes., PMID:26319086
Preclinical Development of an anti-5T4 Antibody-Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice., PMID:26180901
Trophoblast glycoprotein promotes pancreatic ductal adenocarcinoma cell metastasis through Wnt/planar cell polarity signaling., PMID:25738465
Cross-Presentation of the Oncofetal Tumor Antigen 5T4 from Irradiated Prostate Cancer Cells--A Key Role for Heat-Shock Protein 70 and Receptor CD91., PMID:25678582
Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer., PMID:25669203
Evolving Strategies for Target Selection for Antibody-Drug Conjugates., PMID:25585957
TroVax in colorectal cancer., PMID:25483641
Phenotype of TPBG Gene Replacement in the Mouse and Impact on the Pharmacokinetics of an Antibody-Drug Conjugate., PMID:25423493
For research use only. Not for human or drug use.
