Catalog No.
YHG62201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu122-Leu249
Predicted molecular weight
17.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13635
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein patched homolog 1, PTC1, PTCH, PTCH1, PTC
PKR Inhibition Reduces High Glucose and H2O2-Induced Injury in Rat Renal Epithelial Cells by Suppressing the Sonic Hedgehog Pathway., PMID:40516780
Rare Variant Association Analysis Uncovers Involvement of VNN2 in Stroke Outcome., PMID:40495801
Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression., PMID:40393452
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target., PMID:40378836
Silencing HMGB1 secretion inhibited EV71-induced blood-brain barrier dysfunction and neural inflammation by depressing astrocyte activation via sHh signal blockage., PMID:40349912
Hedgehog signalling in solitary motile cilia: detection and role of hedgehog factors in sperm functions and in vitro fertilization., PMID:40338802
Embryonic exposure to Smoothened Agonist disrupts tongue development in mice., PMID:40311729
Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of LSD1 and OXPHOS., PMID:40286267
Increased expression of PTCH1 and GLI1 in Bangladeshi TNBC Patients after Treatment with Doxorubicin and Cyclophosphamide Suggests a Favorable Response to Chemotherapy., PMID:40156412
Identification of RCC2 as a Risk Gene Associated With Basal Cell Carcinoma and Experimental Validation., PMID:40129067
EPS-8 regulates human malignant melanoma development by activating the Hedgehog pathway via degradation of Ptch1., PMID:39978252
Germline Variants in Pediatric Cancer : Based on Oncogenic Pathways., PMID:39961591
Clinicopathologic and Molecular Characterization of Basal Cell Carcinoma Arising at Sun-protected Sites., PMID:39807820
Inhibition of Differentiation of 3T3-L1 Cells by Increasing Glioma-Associated Oncogene Expression in Chrysanthemum indicum L. Using Lactococcus lactis KCTC 3115., PMID:39759806
Congenital urinary tract anomalies are a variable finding associated with nevoid basal cell carcinoma syndrome., PMID:39740804
Essential strategies for the detection of constitutive and ligand-dependent Gi-directed activity of 7TM receptors using bioluminescence resonance energy transfer., PMID:39713355
Pirfenidone promotes cell cycle arrest and apoptosis of triple‑negative breast cancer cells by suppressing Hedgehog/GLI1 signaling., PMID:39621085
A new nonsense mutation of PTCH1 gene in mother and daughter with late-onset nevus basal cell carcinoma syndrome: Case report., PMID:39612443
Dissecting the Impact of Genetic Background on Oncogenic Response to Radiation Exposure in the Ptch1+/- Mouse Model., PMID:39594660
Analysis of Germline and Somatic Mutation in Patients With Developmental Odontogenic Cysts Using Targeted Gene Panel., PMID:39581763
[A case of familial adenomatous polyposis in an adult male with Lynch-like syndrome]., PMID:39572183
Ginsenoside Rg3 enhances the anticancer effects of 5-fluorouracil in colorectal cancer and reduces drug resistance and the Hedgehog pathway activation., PMID:39500672
Curcumin and Methotrexate: A Promising Combination for Osteosarcoma Treatment via Hedgehog Pathway Inhibition., PMID:39457084
Whole‑exome sequencing insights into synchronous bilateral breast cancer with discordant molecular subtypes., PMID:39430730
Sonic hedgehog signaling facilitates pyroptosis in mouse heart following ischemia/reperfusion via enhancing the formation of CARD10-BCL10-MALT1 complex., PMID:39343081
Inherited Basaloid Neoplasms Associated With SUFU Pathogenic Variants., PMID:39292485
Clinicopathological and molecular spectrum of patients with germline SUFU mutations: A case series., PMID:39276021
Effects of Isoxazolyl Steroids on Key Genes of Sonic Hedgehog Cascade Expression in Tumor Cells., PMID:39274874
Examination of piperonyl butoxide developmental toxicity as a Sonic hedgehog pathway inhibitor targeting limb and palate morphogenesis., PMID:39255949
Hedgehog components are overexpressed in a series of liver cancer cases., PMID:39174588
Study of the Immune Infiltration and Sonic Hedgehog Expression Mechanism in Synovial Tissue of Rheumatoid Arthritis-Related Interstitial Lung Disease under Machine Learning CIBERSORT Algorithm., PMID:39110383
New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer., PMID:39106711
Prevalence of KRAS amplification in patients with metastatic cancer: Real-world next-generation sequencing analysis., PMID:39106591
A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma., PMID:39078737
Putative Pharmacological Depression and Anxiety-Related Targets of Calcitriol Explored by Network Pharmacology and Molecular Docking., PMID:39065743
Integrative genomic analysis reveals cancer-associated mutations in patients with ophthalmic tumors., PMID:39053449
Relative Biological Effectiveness of Carbon Ion Beams for Induction of Medulloblastoma with Radiation-specific Chromosome 13 Deletion in Ptch1+/- Mice., PMID:39048112
Roles of astrocytic sonic hedgehog production and its signal for regulation of the blood-brain barrier permeability., PMID:39029978
CPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling., PMID:39029571
Implicating clinical utility of altered expression of PTCH1 & SMO in oral squamous cell carcinoma., PMID:38954185
Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review., PMID:38928661
Applying Spinal Cord Organoids as a quantitative approach to study the mammalian Hedgehog pathway., PMID:38917070
TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway., PMID:38884661
Effects of mesenchymal stem cells versus curcumin on sonic hedgehog signaling in experimental model of Hepatocellular Carcinoma., PMID:38874802
Germline PTCH1: c.361_362insAlu alteration identified by comprehensive exome and RNA sequencing in a patient with Gorlin syndrome., PMID:38864234
Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis., PMID:38848388
Staphylococcal enterotoxin B exposed to pregnant rats inhibits the hedgehog signaling pathway in thymic T lymphocytes of the offspring., PMID:38823465
MiRNA-210 is involved in cigarette smoke extract-induced apoptosis of MLE-12 via the Shh signaling pathway., PMID:38813585
ZMYND8 Is a Regulator of Sonic Hedgehog Signaling in ATRA-Mediated Differentiation of Neuroblastoma Cells., PMID:38804064
AEG-1 as a Novel Therapeutic Target in Colon Cancer: A Study from Silencing AEG-1 in BALB/c Mice to Large Data Analysis., PMID:38783530
For research use only. Not for human or drug use.
