Catalog No.
YHG60001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val319-Gln668
Predicted molecular weight
41.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13591
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SEMA5A, Semaphorin-5A, Sema F, SEMAF, Semaphorin-F
Hsa-miR-21-5p is induced by interleukin-6 and affects multiple pathogenic factors associated with fibroblast-like synoviocytes in rheumatoid arthritis., PMID:40461641
Semaphorin 5A as a Novel Diagnostic Biomarker of Juvenile Idiopathic Arthritis., PMID:40441894
The NEXT complex regulates H3K27me3 levels to affect cancer progression by degrading G4/U-rich lncRNAs., PMID:39988317
Helicobacter pylori virulence factor CagA promotes Snail-mediated epithelial-mesenchymal transition and invasive behavior by downregulating Semaphorin 5A in gastric epithelial cells., PMID:39892055
Semaphorin 5A promotes Th17 differentiation via PI3K-Akt-mTOR in systemic lupus erythematosus., PMID:39563449
A genome-wide CRISPR/Cas9 knockout screen identifies SEMA3F gene for resistance to cyclin-dependent kinase 4 and 6 inhibitors in breast cancer., PMID:39352623
Altered N6-methyladenosine methylation level in spermatozoa messenger RNA of the male partners is related to unexplained recurrent pregnancy loss., PMID:38979761
BET Bromodomain Inhibition Potentiates Ocular Melanoma Therapy by Inducing Cell Cycle Arrest., PMID:38967943
The emerging role of the semaphorin family in cartilage and osteoarthritis., PMID:38849589
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape., PMID:38666924
Structure and function of Semaphorin-5A glycosaminoglycan interactions., PMID:38548715
lncRNA TTTY14 participates in the progression of repeated implantation failure by regulating the miR-6088/SEMA5A axis., PMID:38294620
A three-gene random forest model for diagnosing idiopathic pulmonary fibrosis based on circadian rhythm-related genes in lung tissue., PMID:38285622
RhoG-Binding Domain of Elmo1 Ameliorates Excessive Process Elongation Induced by Autism Spectrum Disorder-Associated Sema5A., PMID:38133141
Exosome-derived miR-182-5p promoted cholangiocarcinoma progression and vasculogenesis by regulating ADK/SEMA5a/PI3K pathway., PMID:37950359
Weighted gene co-expression network analysis of key targets and interventional mechanism of Milkvetch root in diabetic nephropathy., PMID:37916327
A fully human monoclonal antibody targeting Semaphorin 5A alleviates the progression of rheumatoid arthritis., PMID:37832409
Longitudinal Transcriptomic Analysis of Human Cortical Spheroids Identifies Axonal Dysregulation in the Prenatal Brain as a Mediator of Genetic Risk for Schizophrenia., PMID:37661009
SnRNA-Seq analysis reveals ten hub genes associated with alveolar epithelial cell injury during pulmonary acute respiratory distress syndrome., PMID:37389073
Axon Fasciculation, Mediated by Transmembrane Semaphorins, Is Critical for the Establishment of Segmental Specificity of Corticospinal Circuits., PMID:37344234
Identification and validation of immune-related biomarkers and potential regulators and therapeutic targets for diabetic kidney disease., PMID:37127580
A new immune signature for survival prediction and immune checkpoint molecules in non-small cell lung cancer., PMID:36793597
SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis Outgrowth through Enhancing the Warburg Effect., PMID:36741230
Durable response to low-dose pralsetinib in a renal insufficient patient with NSCLC harboring concurrent CCDC6-RET, LINCO1264-RET, and SEMA5A-RET fusions: A case report., PMID:36451418
Circulating small extracellular vesicle-encapsulated SEMA5A-IT1 attenuates myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass., PMID:36284269
Extracellular domain of semaphorin 5A serves a tumor‑suppressing role by activating interferon signaling pathways in lung adenocarcinoma cells., PMID:35059729
Comparative methylation and RNA-seq expression analysis in CpG context to identify genes involved in Backfat vs. Liver diversification in Nanchukmacdon Pig., PMID:34743693
PLXNA2 as a candidate gene in patients with intellectual disability., PMID:34327814
Decreased Lymphangiogenic Activities and Genes Expression of Cord Blood Lymphatic Endothelial Progenitor Cells (VEGFR3+/Pod+/CD11b+ Cells) in Patient with Preeclampsia., PMID:33921847
The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A., PMID:33801296
Relationship between disease and disease severity and semaphorin 5A and hemogram level in obsessive-compulsive disorder., PMID:33771090
Plexin-B3 Regulates Cellular Motility, Invasiveness, and Metastasis in Pancreatic Cancer., PMID:33669221
Analysis of Differentially Expressed Genes in the Dentate Gyrus and Anterior Cingulate Cortex in a Mouse Model of Depression., PMID:33628784
TSP1 is the essential domain of SEMA5A involved in pannus formation in rheumatoid arthritis., PMID:33616619
Circular RNA circSEMA5A promotes bladder cancer progression by upregulating ENO1 and SEMA5A expression., PMID:33176280
Transcriptomic profile of Pea3 family members reveal regulatory codes for axon outgrowth and neuronal connection specificity., PMID:33097800
A Knock-Down Cell-Based Study for the Functional Analysis of Chloride Intracellular Channel 1 (CLIC1): Integrated Proteomics and Microarray Study., PMID:32586242
Olig2-Induced Semaphorin Expression Drives Corticospinal Axon Retraction After Spinal Cord Injury., PMID:32564090
Knocking Out SST Gene of BGC823 Gastric Cancer Cell by CRISPR/Cas9 Enhances Migration, Invasion and Expression of SEMA5A and KLF2., PMID:32110105
Semaphorin 5A suppresses the proliferation and migration of lung adenocarcinoma cells., PMID:31789397
High Expression Levels of Long Noncoding RNA Small Nucleolar RNA Host Gene 18 and Semaphorin 5A Indicate Poor Prognosis in Multiple Myeloma., PMID:31597158
Assessment of the Usefulness of the SEMA5A Concentration Profile Changes as a Molecular Marker in Endometrial Cancer., PMID:31544715
FUS-mediated dysregulation of Sema5a, an autism-related gene, in FUS mice with hippocampus-dependent cognitive deficits., PMID:31509188
De Novo Germline Mutations in SEMA5A Associated With Infantile Spasms., PMID:31354784
Semaphorin-5A downregulation is associated with enhanced migration and invasion of BRAF-positive melanoma cells under vemurafenib treatment in melanomas with heterogeneous BRAF status., PMID:31116162
Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation., PMID:30598261
The association of semaphorins 3C, 5A and 6D with liver fibrosis stage in chronic hepatitis C., PMID:30592759
Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells., PMID:30577767
Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb., PMID:30454024
Differential Methylation of H3K79 Reveals DOT1L Target Genes and Function in the Cerebellum In Vivo., PMID:30302725
For research use only. Not for human or drug use.
