Catalog No.
YHG58601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys401
Predicted molecular weight
46.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13561
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p50 dynamitin, DCTN50, DCTN2, Dynactin subunit 2, DCTN-50, 50 kDa dynein-associated polypeptide, Dynactin complex 50 kDa subunit
Serum inflammation-related proteins in a acute compartment syndrome rat model., PMID:39747444
Thoracic small round cell sarcoma with FGFR2::DCTN2 fusion., PMID:38859769
Pan-cancer analysis of DCTN2 and its tumour-promoting role in HCC by modulating the AKT pathway., PMID:38842133
Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy., PMID:38773124
Dynactin 2 acts as an oncogene in hepatocellular carcinoma through promoting cell cycle progression., PMID:39958200
The expression, localisation and interactome of pigeon CRY2., PMID:34645873
Binding between ROCK1 and DCTN2 triggers diabetes‑associated centrosome amplification in colon cancer cells., PMID:34080666
Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma., PMID:33896271
Cellular and Viral Determinants of HSV-1 Entry and Intracellular Transport towards Nucleus of Infected Cells., PMID:33472938
Role of Phosphorylated Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in the Regulation of Germ Cell Specific mRNAs in Chromatoid Bodies During Spermatogenesis., PMID:33425888
Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila., PMID:33404278
Inherited motor-sensory neuropathy with upper limb predominance associated with the tropomyosin-receptor kinase fused gene., PMID:32085962
Evaluation of Skin Response After Erbium:Yttrium- Aluminum-Garnet Laser Irradiation: A Network Analysis Approach., PMID:31749945
Dynactin pathway-related gene expression is altered by aging, but not by vitrification., PMID:31260804
Distinct prognostic value of dynactin subunit 4 (DCTN4) and diagnostic value of DCTN1, DCTN2, and DCTN4 in colon adenocarcinoma., PMID:30510450
Dynactin is involved in Lewy body pathology., PMID:30215870
Prognostic Value of Dynactin mRNA Expression in Cutaneous Melanoma., PMID:29864111
Proteomic analysis of chicken embryo fibroblast cells infected with recombinant H5N1 avian influenza viruses with and without NS1 eIF4GI binding domain., PMID:29492200
Perry Syndrome: A Distinctive Type of TDP-43 Proteinopathy., PMID:28789478
Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection., PMID:27194765
Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family., PMID:26517670
Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum., PMID:25669897
The functional proteomics analysis of VEGF-treated human epithelial ovarian cancer cells., PMID:25192722
Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5., PMID:25088759
Enhancement of dynein-mediated autophagosome trafficking and autophagy maturation by ROS in mouse coronary arterial myocytes., PMID:24912985
Dynactin integrity depends upon direct binding of dynamitin to Arp1., PMID:24829381
Interaction of foot-and-mouth disease virus nonstructural protein 3A with host protein DCTN3 is important for viral virulence in cattle., PMID:24352458
Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters., PMID:23380587
Disruption of the dynein-dynactin complex unveils motor-specific functions in osteoclast formation and bone resorption., PMID:22887640
Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein., PMID:22726940
New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics., PMID:22402058
The dynactin complex enhances the speed of microtubule-dependent motions of adenovirus both towards and away from the nucleus., PMID:21994728
Dynamics of native β-actin mRNA transport in the cytoplasm., PMID:21518164
Recruitment of dynein to late endosomes and lysosomes through light intermediate chains., PMID:21169557
The dynactin complex maintains the integrity of metaphasic centrosomes to ensure transition to anaphase., PMID:21163948
Molecular and functional basis for the scaffolding role of the p50/dynamitin subunit of the microtubule-associated dynactin complex., PMID:20463029
The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum., PMID:20308060
Effect of chronic mild stress and imipramine on the proteome of the rat dentate gyrus., PMID:20180829
A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration., PMID:19657041
The effects of dynein inhibition on the autophagic pathway in glioma cells., PMID:19496938
Membrane targeting and intracellular trafficking of the human sodium-dependent multivitamin transporter in polarized epithelial cells., PMID:19211916
Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic., PMID:19075109
Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis., PMID:19029334
Geminin is partially localized to the centrosome and plays a role in proper centrosome duplication., PMID:18798731
N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function., PMID:18782227
MTOC translocation modulates IS formation and controls sustained T cell signaling., PMID:18779373
Dynactin is essential for growth cone advance., PMID:18477476
Dynamitin mutagenesis reveals protein-protein interactions important for dynactin structure., PMID:18182012
Apical membrane targeting and trafficking of the human proton-coupled transporter in polarized epithelia., PMID:18003745
Microtubule motors regulate ISOC activation necessary to increase endothelial cell permeability., PMID:17921144
For research use only. Not for human or drug use.
