Catalog No.
YHG55101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn394-Arg656
Predicted molecular weight
31.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13480
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1, GRB2-associated-binding protein 1
Modeling acquired TKI resistance and effective combination therapeutic strategies in murine RET+ lung adenocarcinoma., PMID:40502048
Comprehensive molecular characteristics of hepatocellular carcinoma based on multi-omics analysis., PMID:40159482
Genetic susceptibility to essential hypertension in the Chinese han population: a study on GAB1, GAB2, and GAB3 gene polymorphisms., PMID:40140746
Molecular classification of medulloblastoma using immunohistochemistry: A single centre study., PMID:40056547
Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2., PMID:39974929
miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades., PMID:39571732
Functional Targets for Epstein-Barr Virus BART MicroRNAs in B Cell Lymphomas., PMID:39456631
Exploration of the shared gene signatures and molecular mechanisms between Alzheimer's disease and intracranial aneurysm., PMID:39427050
[Mechanism of Paeoniae Radix Rubra and Aconiti Lateralis Radix Praeparata herbal pair in promoting hepatocellular regeneration in chronic acute liver failure based on HGF/PI3K/Akt signaling axis]., PMID:39307751
Emerging fusion-associated mesenchymal tumours: a tabular guide and appraisal of five 'novel' entities., PMID:39304199
SIK2: A Novel Negative Feedback Regulator of FGF2 Signaling., PMID:39267218
Lactate Oxidase Disrupts Lactate-Activated RAS and PI3K Oncogenic Signaling., PMID:39199589
The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor., PMID:39173814
Deafness DFNB128 Associated with a Recessive Variant of Human MAP3K1 Recapitulates Hearing Loss of Map3k1-Deficient Mice., PMID:39062623
Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis., PMID:38935609
Inhibition of pseudo-allergic reactions by vitamin K3 directly targeting GAB1 in mast cells., PMID:38897121
Molecular Subgrouping Based on Immunohistochemistry in Medulloblastoma: A Single-Center Experience., PMID:38874255
Dysregulated Gab1 signalling in triple negative breast cancer., PMID:38448989
Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes., PMID:38180972
A Case Report of Infant-Type Hemispheric Glioma with a Novel GAB1-ABL2 Kinase Fusion Treated with Dasatinib., PMID:38109857
Dynamic altruistic cooperation within breast tumors., PMID:38093346
Association of GAB1 gene with asthma susceptibility and the efficacy of inhaled corticosteroids in children., PMID:38057792
S-100 and MATH-1 Protein Expressions Can Be Useful for the Prediction of Clinical Outcome in Neuroblastoma Patients., PMID:37943051
A preliminary study on the mechanism of VASH2 in childhood medulloblastoma., PMID:37821528
IGF1R Contributes to Cell Proliferation in ALK-Mutated Neuroblastoma with Preference for Activating the PI3K-AKT Signaling Pathway., PMID:37686528
Loss of EGF receptor polarity enables homeostatic imbalance in epithelial-cell models., PMID:37647145
A novel bivalent anti-c-MET/PD-1 bispecific antibody exhibits potent cytotoxicity against c-MET/PD-L1-positive colorectal cancer., PMID:37646958
The Role of GAB1 in Cancer., PMID:37627207
Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma., PMID:37537194
Immunohistochemical Surrogates for Molecular Stratification in Medulloblastoma., PMID:37471625
HGF/c-Met signaling promotes the migration and proliferation of deer antler MSCs., PMID:37429874
LncRNA AK001796 promotes cell proliferation via acting as a ceRNA of miR-150 in hepatocellular carcinoma., PMID:37272834
Comparative analysis of deeply phenotyped GBM cohorts of 'short-term' and 'long-term' survivors., PMID:37237151
Molecular Mechanisms of the Anti-Inflammatory Effects of Epigallocatechin 3-Gallate (EGCG) in LPS-Activated BV-2 Microglia Cells., PMID:37190597
Upregulation of miR-200a improves ureteral obstruction-induced renal fibrosis via GAB1/Wnt/β-catenin signaling., PMID:37179212
Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL., PMID:37169950
Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis., PMID:37153740
Clinicopathologic and genetic characterization of angiofibroma of soft tissue: a study of 12 cases including two cases with AHRR::NCOA3 gene fusion., PMID:36860189
Progression of Thoracic Aortic Dissection Is Aggravated by the hsa_circ_0007386/miR-1271-5P/IGF1R/AKT Axis via Induction of Arterial Smooth Muscle Cell Apoptosis., PMID:36831107
Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation., PMID:36795486
GAB1::ABL1 fusions define a distinctive soft tissue neoplasm, with variable perineurial differentiation, and a predilection for children and young adults., PMID:36744864
COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by up-regulating Krox20., PMID:36648143
GAB1 as a Marker of Recurrence in Anterior Skull Base Meningioma., PMID:36637273
Clinicomorphological and molecular analysis of medulloblastoma and association with survival: A single tertiary care center experience., PMID:38384024
Network Pharmacology Integrated with Transcriptomics Analysis Reveals Ermiao Wan Alleviates Atopic Dermatitis via Suppressing MAPK and Activating the EGFR/AKT Signaling., PMID:36578822
Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling., PMID:36548088
Pharmacologic Inhibition of SHP2 Blocks Both PI3K and MEK Signaling in Low-epiregulin HNSCC via GAB1., PMID:36506869
The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic Review., PMID:36497451
Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis., PMID:36417441
Gab1 Overexpression Attenuates Susceptibility to Ventricular Arrhythmias in Pressure Overloaded Heart Failure Mouse Hearts., PMID:36374360
For research use only. Not for human or drug use.
