Catalog No.
YHG48401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr392-Leu594
Predicted molecular weight
25.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13322
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GRB10 adapter protein, Growth factor receptor-bound protein 10, KIAA0207, Insulin receptor-binding protein Grb-IR, GRB10, GRBIR
Allelic expression patterns of imprinted and non-imprinted genes in cancer cell lines from multiple histologies., PMID:40414875
Maternal uniparental disomy of chromosome 7: how chromosome 7-encoded imprinted genes contribute to the Silver-Russell phenotype., PMID:40307819
Machine learning-based transcriptmics analysis reveals BMX, GRB10, and GADD45A as crucial biomarkers and therapeutic targets in sepsis., PMID:40230692
Paternal fenvalerate exposure causes depressive-like behaviour by altering Grb10 gene DNA methylation in adolescent offspring., PMID:40043501
Motif-guided identification of KRAS-interacting proteins., PMID:39563372
Enrichment of trimethyl histone 3 lysine 4 in the Dlk1 and Grb10 genes affects pregnancy outcomes due to dietary manipulation of excess folic acid and low vitamin B12., PMID:39543691
Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism., PMID:39343875
Combination of arsenic trioxide and apatinib synergistically inhibits small cell lung cancer by down-regulating VEGFR2/mTOR and Akt/c-Myc signaling pathway via GRB10., PMID:39223679
RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade., PMID:39138413
Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction., PMID:39018414
Genetic variation near GRB10 associated with bone growth and osteosarcoma risk in canine and human populations., PMID:38871555
Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes., PMID:38816743
Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response., PMID:38597182
Multi-Omics Analysis of Genes Encoding Proteins Involved in Alpha-Linolenic Acid Metabolism in Chicken., PMID:37959108
Therapeutic targets for endometriosis: Genome-wide Mendelian randomization and colocalization analyses., PMID:37931855
RILP inhibits tumor progression in osteosarcoma via Grb10-mediated inhibition of the PI3K/AKT/mTOR pathway., PMID:37789274
TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approach., PMID:37535601
Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function., PMID:37517320
Low Expression of GIGYF1 Inhibits Metastasis, Proliferation, and Promotes Apoptosis and Autophagy of Gastric Cancer Cells., PMID:37484805
DNA Methylation of Genes Participating in Hepatic Metabolisms and Function in Fetal Calf Liver Is Altered by Maternal Undernutrition during Gestation., PMID:37445858
GRB10 is a novel factor associated with gastric cancer proliferation and prognosis., PMID:37179120
Erratum to "Erratum to: Proproliferative function of adaptor protein GRB10 in prostate carcinoma"., PMID:36951651
Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson's disease., PMID:36820885
Identification of Epigenetically Regulated Genes Distinguishing Intracranial from Extracranial Melanoma Metastases., PMID:36716920
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss., PMID:36593271
Erratum to "Proproliferative function of adaptor protein GRB10 in prostate carcinoma"., PMID:36583702
Real role of growth factor receptor-binding protein 10: Linking lipid metabolism to diabetes cardiovascular complications., PMID:36569013
Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach., PMID:36497123
The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner., PMID:36354735
Screening of potential biomarkers in peripheral blood of patients with depression based on weighted gene co-expression network analysis and machine learning algorithms., PMID:36325528
CircRNA GRB10 is a Novel Biomarker for the Accurate Diagnosis of Lumbar Degenerative Disc Disease., PMID:36251122
Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development., PMID:36108632
Identification and Validation of a Novel Prognostic Gene Model for Colorectal Cancer., PMID:35924107
GRB10 is a novel oncogene associated with cell proliferation and prognosis in glioma., PMID:35790975
A genome-wide screen for resilient responses in growing pigs., PMID:35787790
circHtra1/miR-3960/GRB10 Axis Promotes Neuronal Loss and Immune Deficiency in Traumatic Brain Injury., PMID:35571247
PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex., PMID:35401828
Novel multilocus imprinting disturbances in a child with expressive language delay and intellectual disability., PMID:35365979
Treadmill training attenuate STZ-induced cognitive dysfunction in type 2 diabetic rats via modulating Grb10/IGF-R signaling., PMID:35065184
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes., PMID:35040927
RNA binding protein HuD promotes autophagy and tumor stress survival by suppressing mTORC1 activity and augmenting ARL6IP1 levels., PMID:35012594
Quantitative assessment of muscle mass and gene expression analysis in dogs with glucocorticoid-induced muscle atrophy., PMID:34980764
GRB10 regulates β-cell mass by inhibiting β-cell proliferation and stimulating β-cell dedifferentiation., PMID:34861413
Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis., PMID:34773240
Regulation of the Golgi Apparatus by p38 and JNK Kinases during Cellular Stress Responses., PMID:34502507
Adaptation of AMPK-mTOR-signal pathways and lipid metabolism in response to low- and high-level rapeseed meal diet in Chinese perch (Siniperca chuatsi)., PMID:34373935
Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p/GRB10 axis., PMID:33969901
Does fresh or frozen embryo transfer affect imprinted gene expressions in human term placenta?, PMID:33571695
Gonadal Cycle-Dependent Expression of Genes Encoding Peptide-, Growth Factor-, and Orphan G-Protein-Coupled Receptors in Gonadotropin- Releasing Hormone Neurons of Mice., PMID:33551743
The relationship between the mTOR signaling pathway and ovarian aging in peak-phase and late-phase laying hens., PMID:33357698
For research use only. Not for human or drug use.
