Catalog No.
YHG46101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser165-Glu592
Predicted molecular weight
50.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13255
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MGLUR1, GRM1, mGluR1, GPRC1A, Metabotropic glutamate receptor 1
[Update of molecular pathology in cartilage tumors]., PMID:40494758
Placental transcriptome reveals the placental brain axis genes and pathways of gestational diabetes mellitus (GDM) affecting offspring neurodevelopment., PMID:40298873
Spinocerebellar Ataxia 44 Caused by a Novel GRM1 Variant: Reviewing the Contrasting Pathogenic Mechanisms Underlying Two GRM1-Associated Hereditary Ataxias., PMID:40199824
GRM1 as a Candidate Gene for Buffalo Fertility: Insights from Genome-Wide Association Studies and Its Role in the FOXO Signaling Pathway., PMID:40004523
Transcriptome analyses of shell color and egg production traits between the uteruses of blue-green eggshell chickens and Hy-Line brown layers., PMID:39471669
An In Vivo Study of LNS8801, a GPER Agonist, in a Spontaneous Melanoma-Prone Mouse Model, TGS., PMID:39282758
Malignant blue melanoma., PMID:39260463
SCA44- and SCAR13-associated GRM1 mutations affect metabotropic glutamate receptor 1 function through distinct mechanisms., PMID:39030902
Detection of GRM1 gene rearrangements in chondromyxoid fibroma: a comparison of fluorescence in-situ hybridisation, RNA sequencing and immunohistochemical analysis., PMID:38890779
Peripheral inflammation triggering central anxiety through the hippocampal glutamate metabolized receptor 1., PMID:38676295
Tyrosinase-Based Proximity Labeling in Living Cells and In Vivo., PMID:38445591
GRM1-Rearranged Chondromyxoid Fibroma With FGF23 Expression: A Potential Pitfall in Small Biopsies., PMID:38303543
Cytopathology of Chondromyxoid Fibroma: Report of 2 Cases with Immunocytochemical Expression of GRM1., PMID:38281480
Spinal Cord Injury Affects Gene Expression of Transmembrane Proteins in Tissue and Release of Extracellular Vesicle in Blood: In Silico and In Vivo Analysis., PMID:38071409
Severe Neurodevelopmental Disorder in Autosomal Recessive Spinocerebellar Ataxia 13 (SCAR13) Caused by Two Novel Frameshift Variants in GRM1., PMID:37831383
mGluR1/IP3/ERK signaling pathway regulates vestibular compensation in ON UBCs of the cerebellar flocculus., PMID:37622292
GRM1 Gene Fusions as an Alternative Molecular Driver in Blue Nevi and Related Melanomas., PMID:37391170
Scutellarin Alleviates Ischemic Brain Injury in the Acute Phase by Affecting the Activity of Neurotransmitters in Neurons., PMID:37049959
Subcutaneous chondromyxoid fibroma with a novel PNISR::GRM1 fusion-report of a primary soft tissue tumour without connection to an underlying bone., PMID:36810795
Genetic Variant in GRM1 Underlies Congenital Cerebellar Ataxia with No Obvious Intellectual Disability., PMID:36675067
Transcriptional regulation of NRF1 on metabotropic glutamate receptors in a neonatal hypoxic‑ischemic encephalopathy rat model., PMID:36280709
The impact of Mendelian sleep and circadian genetic variants in a population setting., PMID:36137075
Active Compounds and Targets of Yuanzhi Powder in Treating Alzheimer's Disease and Its Relationship with Immune Infiltration Based on HPLC Fingerprint and Network Pharmacology., PMID:35873623
GRM1 Immunohistochemistry Distinguishes Chondromyxoid Fibroma From its Histologic Mimics., PMID:35650682
Altered Expression and In Vivo Activity of mGlu5 Variant a Receptors in the Striatum of BTBR Mice: Novel Insights Into the Pathophysiology of Adult Idiopathic Forms of Autism Spectrum Disorders., PMID:35139800
circ‑Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS., PMID:34528696
Urinary mRNA Expression of Glomerular Podocyte Markers in Glomerular Disease and Renal Transplant., PMID:34441433
Examination of CA1 Hippocampal DNA Methylation as a Mechanism for Closing of Estrogen's Critical Window., PMID:34421577
Glutamatergic Signaling a Therapeutic Vulnerability in Melanoma., PMID:34359771
The Role of Stress-Induced Changes of Homer1 Expression in Stress Susceptibility., PMID:34225586
Systematic investigation of the pharmacological mechanism of Tanreqing injection in treating respiratory diseases by UHPLC/Q-TOF-MS/MS based on multiple in-house chemical libraries coupled with network pharmacology., PMID:34015594
Whole exome sequencing revealed novel variants in consanguineous Pakistani families with intellectual disability., PMID:33710595
Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons., PMID:33548033
Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy., PMID:33408092
Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait., PMID:33065013
Immediate changes in transcription factors and synaptic transmission in the cochlea following acoustic trauma: A gene transcriptome study., PMID:32417196
Isoflurane Preconditioning Protects the Myocardium Against Ischemia and Reperfusion Injury by Upregulating GRM1 Expression., PMID:32048972
Nonhomologous end-joining repair is likely involved in the repair of double-stranded DNA breaks induced by riluzole in melanoma cells., PMID:31855905
Ginsenoside Rg3 and Korean Red Ginseng extract epigenetically regulate the tumor-related long noncoding RNAs RFX3-AS1 and STXBP5-AS1., PMID:31700260
Identification of gene and microRNA changes in response to smoking in human airway epithelium by bioinformatics analyses., PMID:31568004
Lymph node metastasis in lung squamous cell carcinoma and identification of metastasis-related genes based on the Cancer Genome Atlas., PMID:31482686
Distinct gene alterations between Fos-expressing striatal and thalamic neurons after withdrawal from methamphetamine self-administration., PMID:31364821
A novel truncating variant p.(Arg297*) in the GRM1 gene causing autosomal-recessive cerebellar ataxia with juvenile-onset., PMID:31319223
Role of melanoma inhibitory activity in melanocyte senescence., PMID:31172672
In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis., PMID:31102766
The glutamate release inhibitor riluzole increases DNA damage and enhances cytotoxicity in human glioma cells, in vitro and in vivo., PMID:31073373
Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1+ Melanoma., PMID:30987979
Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer., PMID:30391781
Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer., PMID:30375476
For research use only. Not for human or drug use.
