Catalog No.
YHG45101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala193-Asn466
Predicted molecular weight
32.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13231
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Chitinase-1, Chitotriosidase-1, CHIT1
Synaptic pruning genes networks in Alzheimer's disease: correlations with neuropathology and cognitive decline., PMID:40515808
Human chitinases and chitinase-like proteins as emerging drug targets - a medicinal chemistry perspective., PMID:40313579
Skeletal muscle biomarkers of amyotrophic lateral sclerosis: a large-scale, multi-cohort proteomic study., PMID:40313273
Proximity extension assay reveals serum inflammatory biomarkers in two amyotrophic lateral sclerosis cohorts., PMID:40306441
Immunological Fluid Biomarkers in Frontotemporal Dementia: A Systematic Review., PMID:40305176
Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing., PMID:40098951
Neutrophil extracellular traps and macrophage activation contibute to thrombosis and post-covid syndrome in SARS-CoV-2 infection., PMID:40066452
Biological signatures in the Alzheimer's continuum discriminate between diagnosis-related and -unrelated associations to ATN categories., PMID:40046342
A single-cell map of patients with non-small cell lung cancer harboring rare-driver mutations after anti-PD-1 treatment., PMID:40021042
Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: Evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohort., PMID:39989429
Rapid and Differential Diagnosis of Sepsis Stages Using an Advanced 3D Plasmonic Bimetallic Alloy Nanoarchitecture-Based SERS Biosensor Combined with Machine Learning for Multiple Analyte Identification., PMID:39960361
CHIT1 regulates the neuroinflammation and phagocytosis of microglia and suppresses Aβ plaque deposition in Alzheimer's disease., PMID:39829408
Expression and functional analysis of mouse chitinases without the ZZ domain of Staphylococcus aureus Protein A., PMID:39824406
Neuroprotective effects of chitinase-1 and calcitonin gene-related peptide on Alzheimer's disease by promoting lysosomal function., PMID:39814340
Hydrolysis of chitin and chitosans by the human chitinolytic enzymes: chitotriosidase, acidic mammalian chitinase, and lysozyme., PMID:39805453
A Simplified Method for Evaluating Chitin-Binding Activity Applied to YKL-40 (HC-gp39, CHI3L1) and Chitotriosidase., PMID:39795077
Molecular Evolution of the Ovgp1 Gene in the Subfamily Murinae., PMID:39794998
Extracellular vesicles from adipose-derived stem cell alleviate diabetic cardiomyopathy by regulating Chit1/NLRP3/Caspase-1-Mediated pyroptosis., PMID:39700960
Determination of selected oxysterol levels, oxidative stress, and macrophage activation indicators in children and adolescents with familial hypercholesterolemia., PMID:39538217
3D structural insights into the effect of N-glycosylation in human chitotriosidase variant G102S., PMID:39521151
Computational identification and characterization of chitinase 1 and chitinase 2 from neotropical isolates of Beauveria bassiana., PMID:39493578
Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease., PMID:39385222
Chitinase 1: a novel therapeutic target in metabolic dysfunction-associated steatohepatitis., PMID:39381000
Exploiting the role of CSF NfL, CHIT1, and miR-181b as potential diagnostic and prognostic biomarkers for ALS., PMID:39340541
Genomic Insights into Idiopathic Granulomatous Mastitis through Whole-Exome Sequencing: A Case Report of Eight Patients., PMID:39201744
Assessing seasonal variations of biomarkers in inflammatory bowel disease., PMID:38973542
Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease., PMID:38947065
Deficiency of Glucocerebrosidase Activity beyond Gaucher Disease: PSAP and LIMP-2 Dysfunctions., PMID:38928321
Hematopoietic stem cell transplantation or enzyme replacement therapy in Gaucher disease type 3., PMID:38909587
CHIT1 at diagnosis predicts faster disability progression and reflects early microglial activation in multiple sclerosis., PMID:38866782
The Exploitation of the Glycosylation Pattern in Asthma: How We Alter Ancestral Pathways to Develop New Treatments., PMID:38785919
Evolutionary insights into sequence modifications governing chitin recognition and chitinase inactivity in YKL-40 (HC-gp39, CHI3L1)., PMID:38750795
CD138 as a Specific CSF Biomarker of Multiple Sclerosis., PMID:38669615
The Expression and Secretion Profile of TRAP5 Isoforms in Gaucher Disease., PMID:38667330
Enhanced levels of fractalkine and HSP60 in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis patients., PMID:38625841
Skeletal muscle of young females under resistance exercise exhibits a unique innate immune cell infiltration profile compared to males and elderly individuals., PMID:38578562
GBA1 as a risk gene for osteoporosis in the specific populations and its role in the development of Gaucher disease., PMID:38575988
[Investigation of the immune profile of multiple myeloma patients achieving long-term survival after autologous stem cell transplantation]., PMID:38561281
Metabolism-driven glycosylation represents therapeutic opportunities in interstitial lung diseases., PMID:38550597
Natalizumab promotes anti-inflammatory and repair effects in multiple sclerosis., PMID:38527011
A Brazilian Rare-Disease Center's Experience with Glucosylsphingosine (lyso-Gb1) in Patients with Gaucher Disease: Exploring a Novel Correlation with IgG Levels in Plasma and a Biomarker Measurement in CSF., PMID:38474117
Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1., PMID:38427954
Effect of supersaturated dissolved oxygen on growth-, survival-, and immune-related gene expression of Pacific white shrimp (Litopenaeus vannamei)., PMID:38406361
Soluble mannose receptor: A potential biomarker in Gaucher disease., PMID:38200687
Chitinases as a potential diagnostic and prognostic biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis., PMID:38194198
Real life data: follow-up assessment on Spanish Gaucher disease patients treated with eliglustat. TRAZELGA project., PMID:38102667
Data-independent acquisition proteomics of cerebrospinal fluid implicates endoplasmic reticulum and inflammatory mechanisms in amyotrophic lateral sclerosis., PMID:38087504
Effect of sodium phenylbutyrate and taurursodiol on plasma concentrations of neuroinflammatory biomarkers in amyotrophic lateral sclerosis: results from the CENTAUR trial., PMID:38050066
Circulating 18-Glycosyl Hydrolase Protein Chitiotriosidase-1 is Associated with Renal Dysfunction and Systemic Inflammation in Diabetic Kidney Disease., PMID:38023595
Safety and Clinical Effects of a Muse Cell-Based Product in Patients With Amyotrophic Lateral Sclerosis: Results of a Phase 2 Clinical Trial., PMID:38014622
For research use only. Not for human or drug use.
