Catalog No.
YHG32001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro23-Ala555
Predicted molecular weight
61.83 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q12879
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
N-methyl D-aspartate receptor subtype 2A, NMDAR2A, Glutamate [NMDA] receptor subunit epsilon-1, hNR2A, NR2A, Glutamate receptor ionotropic, NMDA 2A, GRIN2A, GluN2A
[Landau-Kleffner Syndrome: Current Etiopathogenesis and Management]., PMID:40464423
Schizophrenia-like phenotypes and long-term synaptic plasticity impairment in GluN2A-transgenic mice., PMID:40306373
Development of GluN2A NMDA receptor positive allosteric modulators: Recent advances and perspectives., PMID:40239379
Disrupted synaptic gene expression in Fabry disease: Findings from RNA sequencing., PMID:40233852
p53 inhibition during audiogenic kindling in Krushinsky-Molodkina rats attenuates seizure severity and prevents neurodegeneration in the hippocampus., PMID:40210194
Long-Term Phenotypic Evolution in GRIN2A-Related Disorders: Electroclinical and Genetic Insights from Two Families with Extended Follow-Up., PMID:40149474
The effects of risperidone and voluntary exercise intervention on synaptic plasticity gene expressions in the hippocampus and prefrontal cortex of juvenile female rats., PMID:40096936
Rapid and cumulative adult plasticity in the mouse visual cortex., PMID:40093861
Arg209Lys and Gln508His missense variants in Rabphilin 3A cause pre- and post-synaptic dysfunctions at excitatory glutamatergic synapses., PMID:40082528
Astrocytic GluN2A alleviates sleep deprivation-induced elevation of Aβ through regulating neprilysin and AQP4 via the calcineurin/NFAT pathway., PMID:40032156
Activation of NR2A-Wnt-TLR2 Signaling Axis in Satellite Glial Cells of the Dorsal Root Ganglion Contributes to Neuropathic Pain Induced by Nerve Injury in Diabetic Mice., PMID:39964585
Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration., PMID:39960408
Evaluation of allosteric N-methyl-d-aspartate receptor modulation by GluN2A-selective antagonists using pharmacological equilibrium modeling., PMID:39919165
B cells upregulate NMDARs, respond to extracellular glutamate, and express mature BDNF to protect the brain from ischemic injury., PMID:39900302
TP53 Mutations and PD-L1 Amplification in Vulvar Adenocarcinoma of the Intestinal Type: Insights From Whole Exome Sequencing of 2 Cases., PMID:39868745
Assembly and architecture of endogenous NMDA receptors in adult cerebral cortex and hippocampus., PMID:39855198
Schizophrenia-related Xpo7 haploinsufficiency leads to behavioral and nuclear transport pathologies., PMID:39774335
Hippocampus carbonic anhydrase 1 via ERK pathway may be involved in depressive like behaviors., PMID:39722330
Altered TP53, CDKN2A, ATM, EPHA7, POT1, CHEK1, GRIN2A, and EGFR Predict Shorter Survival in Penile Squamous Cell Carcinoma., PMID:39694330
Identification of early Alzheimer's disease subclass and signature genes based on PANoptosis genes., PMID:39650656
Crocin nano-chitosan-coated compound mitigates hippocampal blood-brain barrier disruption, anxiety, and cognitive deficits in chronic immobilization stress-induced rats., PMID:39640648
Regulation of NMDAR activation efficiency by environmental factors and subunit composition., PMID:39576244
Molecular Signatures of Resilience to Alzheimer's Disease in Neocortical Layer 4 Neurons., PMID:39574639
Activity-Dependent Internalization of Glun2B-Containing NMDARs Is Required for Synaptic Incorporation of Glun2A and Synaptic Plasticity., PMID:39562042
Ligand distances as key predictors of pathogenicity and function in NMDA receptors., PMID:39535073
Baseline-dependent enhancement of working memory by memantine in male rats: Involvement of NMDA receptor subunits and CaMKII signaling., PMID:39522650
A chloro substituted organoselenium mitigates stress-associated memory impairment and hippocampal glutamatergic function in a repeated Forced Swim Stress Model., PMID:39521324
AMPA and NMDA Receptors in Hippocampus of Rats with Fluoride-Induced Cognitive Decline., PMID:39519348
Differential Gene Expression in Late-Onset Friedreich Ataxia: A Comparative Transcriptomic Analysis Between Symptomatic and Asymptomatic Sisters., PMID:39519164
GRIN2A and Schizophrenia: Scientific Evidence and Biological Mechanisms., PMID:39501956
Clinical phenotype and functional influence of GRIN2A variants in epilepsy-aphasia syndrome., PMID:39474911
Postnatal Neuronal Nogo-A Knockdown Decreased the Message of Glutamatergic Synaptic Proteins., PMID:39465566
MK-801-exposure induces increased translation efficiency and mRNA hyperacetylation of Grin2a in the mouse prefrontal cortex., PMID:39460980
Genome-Wide Search for Nonadditive Allele Effects Identifies PSKH2 as Involved in the Variability of Factor V Activity., PMID:39424413
GlyT1 inhibition promotes neuroprotection in the middle cerebral artery occlusion model through the activation of GluN2A-containing NMDAR., PMID:39424040
Bi-directional allosteric pathway in NMDA receptor activation and modulation., PMID:39396999
Spitz melanoma with MAP3K8::ABLIM1 rearrangement: a case report with review of the literature., PMID:39363234
The crucial role of NR2A mediating the activation of satellite glial cells in the trigeminal ganglion contributes to orofacial inflammatory pain during TMJ inflammation., PMID:39357737
[Significance of immunological markers in patients with obstructive sleep apnea and comorbid pathology]., PMID:39269296
Synaptic rearrangement of NMDA receptors controls memory engram formation and malleability in the cortex., PMID:39213354
Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications., PMID:39210294
GluN2A: A Promising Target for Developing Novel Antidepressants., PMID:39185814
Double gonosomal mosaicism as an unusual hereditary mechanism in familial GRIN2A-related disorder., PMID:39084904
RNA-sequencing reveals a shared neurotranscriptomic profile in the medial preoptic area of highly social songbirds and rats., PMID:39052331
Interplay of miRNAs and molecular pathways in spaceflight-induced depression: Insights from a rat model using simulated complex space environment., PMID:39037540
Exploration on the potential efficacy and mechanism of methyl salicylate glycosides in the treatment of schizophrenia based on bioinformatics, molecular docking and dynamics simulation., PMID:39019913
N-methyl-D-aspartate Receptor Subunits 2A and 2B Mediate Connexins and Pannexins in the Trigeminal Ganglion Involved in Orofacial Inflammatory Allodynia during Temporomandibular Joint Inflammation., PMID:38976127
Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice., PMID:38961057
Prenatal stress alters transcription of NMDA-type glutamate receptors in the hippocampus., PMID:38917870
Decoding frontotemporal and cell-type-specific vulnerabilities to neuropsychiatric disorders and psychoactive drugs., PMID:38864245
For research use only. Not for human or drug use.
