Catalog No.
YHG30601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu473-Cys605
Predicted molecular weight
17.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q12840
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NKHC1, KIF5A, Kinesin heavy chain isoform 5A, Neuronal kinesin heavy chain, Kinesin heavy chain neuron-specific 1, NKHC
Burden of pathogenetic and likely pathogenetic variants in SPG7, SPG11 and AP4 genes in Amyotrophic Lateral Sclerosis. A case-control study., PMID:40498122
KIF5A variant in familial dystonia: A clinicogenetic study of a large Roma kindred., PMID:40311553
A novel antidepressant mechanism of baicalin: enhancing KIF5A-mediated axoplasmic transport and vesicular trafficking in glutamatergic neurons., PMID:40290440
In vivo changes in zebrafish anesthetic sensitivity in response to the loss of kif5Aa are associated with the alteration of mitochondrial motility., PMID:39763736
The gE/gI complex is necessary for kinesin-1 recruitment during alphaherpesvirus egress from neurons., PMID:39651860
KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons., PMID:39644980
Ergotamine Targets KIF5A to Facilitate Anoikis in Lung Adenocarcinoma., PMID:39517115
Altered molecular and cellular mechanisms in KIF5A-associated neurodegenerative or neurodevelopmental disorders., PMID:39333504
KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons., PMID:39314491
ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons., PMID:39227882
Specific kinesin and dynein molecules participate in the unconventional protein secretion of transmembrane proteins., PMID:39198224
The ALS-associated KIF5A P986L variant is not pathogenic for Drosophila motoneurons., PMID:39174694
Genetic link between KIF1A mutations and amyotrophic lateral sclerosis: evidence from whole-exome sequencing., PMID:39076207
NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors., PMID:39014476
Whole-Genome Sequencing Identified a Novel Mutation in the N-Terminal Domain of KIF5A in Chinese Patients with Familial Amyotrophic Lateral Sclerosis., PMID:38927616
FOXP3 targets KIF5A to increase lactate production and promote docetaxel resistance in lung adenocarcinoma., PMID:38798241
Paraquat disrupts KIF5A-mediated axonal mitochondrial transport in midbrain neurons and its antagonism by melatonin., PMID:38750743
A multiscale approach reveals the molecular architecture of the autoinhibited kinesin KIF5A., PMID:38309508
Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration., PMID:38239833
Computational study of the motor neuron protein KIF5A to identify nsSNPs, bioactive compounds, and its key regulators., PMID:38028604
Insect Cell-Based Expression of Cytoskeletal Motor Proteins for Single-Molecule Studies., PMID:37824000
ALS-Associated KIF5A Mutation Causes Locomotor Deficits Associated with Cytoplasmic Inclusions, Alterations of Neuromuscular Junctions, and Motor Neuron Loss., PMID:37748861
The choroidal nervous system: a link between mineralocorticoid receptor and pachychoroid., PMID:37682293
Heterogeneous splicing patterns resulting from KIF5A variants associated with amyotrophic lateral sclerosis., PMID:37593923
A human proteogenomic-cellular framework identifies KIF5A as a modulator of astrocyte process integrity with relevance to ALS., PMID:37386082
The genetic and clinical spectrum in a cohort of 39 families with complex inherited peripheral neuropathies., PMID:37365282
Charcot-Marie-Tooth Disease Type 2-Like Phenotype due to a Novel Variant in the Stalk Domain of KIF5A., PMID:37322770
Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABAA receptor transport in a murine model., PMID:37258573
Impaired motor unit recovery and maintenance in a knock-in mouse model of ALS-associated Kif5a variant., PMID:37164288
Advantages of routine next-generation sequencing over standard genetic testing in the amyotrophic lateral sclerosis clinic., PMID:37159497
Could some mutations of the KIF5A gene be responsible for a dominant CMT2 phenotype? (Case report)., PMID:37084037
Generation of recombinant and chickenized scFv versions of an anti-kinesin monoclonal antibody H2., PMID:37036074
In Silico Exploration of Metabolically Active Peptides as Potential Therapeutic Agents against Amyotrophic Lateral Sclerosis., PMID:36982902
Kif5a Regulates Mitochondrial Transport in Developing Retinal Ganglion Cells In Vitro., PMID:36862119
Novel mutation in KIF5A gene associated with hereditary motor and sensory neuropathy and cognitive impairment: a case report and literature review., PMID:36696008
KIF5A upregulation in hepatocellular carcinoma: A novel prognostic biomarker associated with unique tumor microenvironment status., PMID:36686769
Expanding the spectrum of KIF5A mutations-case report of a large kindred with familial ALS and overlapping syndrome., PMID:36604770
Road-blocker HSP disease mutation disrupts pre-organization for ATP hydrolysis in kinesin through a second sphere control., PMID:36574689
Bioinformatics analysis: relationship between adrenocortical carcinoma and KIFs., PMID:36572958
Generation of an iPSC line from a patient with spastic paraplegia type 10 carrying a novel mutation in KIF5A gene., PMID:36565680
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease., PMID:36544231
Mesenchymal stem cells shuttling miR-503 via extracellular vesicles enhance glioma immune escape., PMID:36524211
APC couples neuronal mRNAs to multiple kinesins, EB1, and shrinking microtubule ends for bidirectional mRNA motility., PMID:36469763
[Genetic distribution in Chinese patients with hereditary peripheral neuropathy]., PMID:36241230
Clinical relevance of single-subject brain metabolism patterns in amyotrophic lateral sclerosis mutation carriers., PMID:36223668
HIF‑1α protects PC12 cells from OGD/R‑induced cell injury by regulating autophagy flux through the miR‑20a‑5p/KIF5A axis., PMID:36214718
Phenotypic and Genetic Heterogeneity of Adult Patients with Hereditary Spastic Paraplegia from Serbia., PMID:36139378
Lab resource: Single cell line generation and characterization of a human-derived induced pluripotent stem cell line (IGIBi005-A) from a patient with spastic paraplegia/ataxia/ALS phenotype due to the mutation of the gene Kinesin Family Member 5A (KIF5A)., PMID:36055117
Dominantly acting KIF5B variants with pleiotropic cellular consequences cause variable clinical phenotypes., PMID:36018820
For research use only. Not for human or drug use.
