Catalog No.
YHG16901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser269
Predicted molecular weight
32.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08495
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EPB49, Erythrocyte membrane protein band 4.9, DMT, Dematin, DMTN, Dematin actin-binding protein
Key Genes FECH and ALAS2 under Acute High-Altitude Exposure: A Gene Expression and Network Analysis Based on Expression Profile Data., PMID:39202434
Potential pathogenetic role of a novel ABCC8 missense variant on both transient neonatal diabetes mellitus and fetal growth restriction: a case report., PMID:38874636
Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt Activation in Platelets., PMID:37216480
Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling., PMID:35561787
Developmental ethanol exposure causes central nervous system dysfunction and may slow the aging process in a Drosophila model of fetal alcohol spectrum disorder., PMID:33961967
MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma., PMID:31927122
Hypermethylation of DMTN promotes the metastasis of colorectal cancer cells by regulating the actin cytoskeleton through Rac1 signaling activation., PMID:30514346
Early transition from insulin to sulfonylureas in neonatal diabetes and follow-up: Experience from China., PMID:28791793
Transient neonatal diabetes mellitus and activating mutation in the KCNJ11 gene in two siblings., PMID:28347637
A Newborn with Transient Diabetes Mellitus Accompanied by Ketoacidosis Attributable to a ZFP57 Mutation., PMID:28334746
Clinical and genetic features of Argentinian children with diabetes-onset before 12months of age: Successful transfer from insulin to oral sulfonylurea., PMID:27329029
Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57., PMID:27075368
Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia., PMID:27073223
Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans., PMID:26323243
Clinical characteristics and molecular genetic analysis of 22 patients with neonatal diabetes from the South-Eastern region of Turkey: predominance of non-KATP channel mutations., PMID:25755231
Spectrin binding motifs regulate Scribble cortical dynamics and polarity function., PMID:25664942
Radiographic contrast media alterate the localization of actin/band4.9 in the membrane cytoskeleton of human erythrocytes., PMID:25227200
The human erythrocyte plasma membrane: a Rosetta Stone for decoding membrane-cytoskeleton structure., PMID:24210427
Dematin, a human erythrocyte cytoskeletal protein, is a substrate for a recombinant FIKK kinase from Plasmodium falciparum., PMID:23973789
Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1., PMID:23499433
Neurodegeneration in a Drosophila model for the function of TMCC2, an amyloid protein precursor-interacting and apolipoprotein E-binding protein., PMID:23409049
The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9)., PMID:23355471
Headpiece domain of dematin regulates calcium mobilization and signaling in platelets., PMID:23060452
Identification of a novel role for dematin in regulating red cell membrane function by modulating spectrin-actin interaction., PMID:22927433
Proteomic analysis shows the upregulation of erythrocyte dematin in zinc-restricted human subjects., PMID:22456662
Atomic force microscopy demonstration of cytoskeleton instability in mouse erythrocytes with dematin-headpiece and β-adducin deficiency., PMID:21638291
Dematin, a component of the erythrocyte membrane skeleton, is internalized by the malaria parasite and associates with Plasmodium 14-3-3., PMID:21084299
Comparison of fast backbone dynamics at amide nitrogen and carbonyl sites in dematin headpiece C-terminal domain and its S74E mutant., PMID:20396930
Regulatory models of RhoA suppression by dematin, a cytoskeletal adaptor protein., PMID:19262171
Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain., PMID:19241372
Phosphorylation-induced changes in backbone dynamics of the dematin headpiece C-terminal domain., PMID:19030997
The headpiece domain of dematin regulates cell shape, motility, and wound healing by modulating RhoA activation., PMID:18505823
Erythrocyte dematin is a candidate gene for Marie Unna hereditary hypotrichosis and related hairloss disorders., PMID:18273904
Combined deletion of mouse dematin-headpiece and beta-adducin exerts a novel effect on the spectrin-actin junctions leading to erythrocyte fragility and hemolytic anemia., PMID:17142833
Identification of the PXW sequence as a structural gatekeeper of the headpiece C-terminal subdomain fold., PMID:16697408
A phosphorylation-induced conformation change in dematin headpiece., PMID:16472756
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability., PMID:15923635
The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site., PMID:14660664
Headpiece domain of dematin is required for the stability of the erythrocyte membrane., PMID:12011427
Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways., PMID:11856323
Loss of heterozygosity on 8p in prostate cancer implicates a role for dematin in tumor progression., PMID:10565303
cDNA sequence, genomic structure, and expression of the mouse dematin gene (Epb4.9)., PMID:10501976
Alternative splicing and structure of the human erythroid dematin gene., PMID:9655941
Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein., PMID:9245787
Human erythrocyte dematin and protein 4.2 (pallidin) are ATP binding proteins., PMID:8608138
The actin binding site of thymosin beta 4 mapped by mutational analysis., PMID:8617195
Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily., PMID:7615546
The gene encoding the erythrocyte membrane skeleton protein dematin (Epb4.9) maps to mouse chromosome 14., PMID:7607697
Cloning of human erythroid dematin reveals another member of the villin family., PMID:8341682
The junctional complex of the membrane skeleton., PMID:8434261
For research use only. Not for human or drug use.
