Catalog No.
YHG16502
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu24-Cys387
Predicted molecular weight
43.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08431
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MFGM, HMFG, MFG-E8, MFGE8, SED1, Milk fat globule-EGF factor 8, Breast epithelial antigen BA46, Lactadherin
Association of the single-nucleotide polymorphism in the MFG-E8 gene with coronary heart disease in Chinese Han population., PMID:40413414
The Age-dependent Influence of the Infrapatellar Fat Pad on Chondrocyte Extracellular Matrix Production., PMID:40375383
An enzyme-proof glycan glue for extracellular matrix to ameliorate intervertebral disc degeneration., PMID:40240357
MFGE8 regulates the EndoMT of HLMECs through the BMP signaling pathway and fibrosis in acute lung injury., PMID:40223052
Xin-shu-bao tablets ameliorates ventricular remodeling against HFrEF via PPARγ/MFGE8 pathway based on MALDI-MSI and lipidomics., PMID:40216048
Identifying Potential Drug Targets in Coronary Atherosclerosis: Insights from the Druggable Genome and Mendelian Randomization., PMID:40214710
BTN3A2 interacted with MFGE8 to alleviate preeclampsia by promoting ferroptosis and inhibiting angiogenesis., PMID:40147528
MFGE-8, a Corona Protein on Extracellular Vesicles, Mediates Self-Renewal and Survival of Human Pluripotent Stem Cells., PMID:40130745
[The regulation and mechanism of apolipoprotein A5 on myocardial lipid deposition]., PMID:40065613
Osteosarcoma Cell-Derived Migrasomes Promote Macrophage M2 Polarization to Aggravate Osteosarcoma Proliferation and Metastasis., PMID:40056029
Porcine milk small extracellular vesicles modulate peripheral blood mononuclear cell proteome in vitro., PMID:40055486
Phosphatidylserine induce thrombotic tendency and liver damage in obstructive jaundice., PMID:40050731
The role of CTGF and MFG-E8 in the prognosis assessment of SCAP: a study combining machine learning and nomogram analysis., PMID:39917305
Genistein alleviates rheumatoid arthritis by inhibiting fibroblast-like synovial exosome secretion regulated by the Rab27/nSMase2/Mfge8 pathway., PMID:39895262
Emerging Roles for MFG-E8 in Synapse Elimination., PMID:39891478
Isolation of Human BAMBIhighMFGE8high Umbilical Cord-Derived Mesenchymal Stromal Cells., PMID:39878935
MFGE8 Acts as a Cell Adhesion Factor for Human-Induced Pluripotent Stem Cells in Embryology., PMID:39869126
MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1., PMID:39842432
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis., PMID:39813006
Acetylation-ubiquitination crosstalk of DJ-1 mediates microcalcification formation in diabetic plaques via collagen-matrix vesicles interaction., PMID:39786474
Proteomic Analysis of Mesenchymal Stem Cell-derived Exosomes in Psoriasis., PMID:39779548
Potentiating microglial efferocytosis by MFG-E8 improves survival and neurological outcome after successful cardiopulmonary resuscitation in mice., PMID:39717017
Milk fat globule-epidermal growth factor 8 exerts anti-osteoarthritis effects by inhibiting apoptosis and inducing autophagy in mouse chondrocytes., PMID:39608050
MFGE8 promotes gastric cancer progression by activating the IL-6/JAK/STAT3 signaling., PMID:39490801
Milk Fat Globules: 2024 Updates., PMID:39474586
Rapid increase of MFGE8 secretion from endometrial epithelial cells is an indicator of extracellular vesicle mediated embryo maternal dialogue., PMID:39472639
Milk fat globule-epidermal growth factor-VIII-derived oligopeptide 3 (MOP3) attenuates inflammation and improves survival in hepatic ischemia/reperfusion injury., PMID:39455391
The Altered Proteomic Landscape in Renal Tubular Epithelial Cells under High Oxalate Stimulation., PMID:39452123
Phosphatidylserine-mediated uptake of extracellular vesicles by hepatocytes ameliorates liver ischemia-reperfusion injury., PMID:39397123
Medin, a link between vascular pathology and dementia?, PMID:39370976
Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia., PMID:39361088
Milk fat globule EGF and factor V/VIII domain containing-mediated osteoimmunology in periodontal disease., PMID:39321103
MFG-E8 Ameliorates Nerve Injury-Induced Neuropathic Pain by Regulating Microglial Polarization and Neuroinflammation via Integrin β3/SOCS3/STAT3 Pathway in Mice., PMID:39305375
Small extracellular vesicles derived from adipose mesenchymal stem cells alleviate intestinal fibrosis by inhibiting the FAK/Akt signaling pathway via MFGE8., PMID:39305336
Glia maturation factor-γ regulates amyloid-β42 phagocytosis through scavenger receptor class A type I in murine macrophages., PMID:39243388
Computational insights into the aggregation mechanism and amyloidogenic core of aortic amyloid medin polypeptide., PMID:39226847
Investigating Medin Cleavage Accessibility in MfgE8: Conformational Insights Derived from Molecular Dynamics Simulations and AlphaFold2 Models., PMID:39131300
MFGE8 promotes adult hippocampal neurogenesis in rats following experimental subarachnoid hemorrhage via modifying the integrin β3/Akt signaling pathway., PMID:39128910
Microglia through MFG-E8 signaling decrease the density of degenerating neurons and protect the brain from the development of cortical infarction after stroke., PMID:39110702
Milk Fat Globule-EGF Factor 8 (MFGE8) Mitigates Cognitive Impairment in Rats with Sepsis-Associated Encephalopathy: An fMRI Study., PMID:39082291
RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway., PMID:38995840
Contribution of circulating Mfge8 to human T2DM and cardiovascular disease., PMID:38901535
Resveratrol and piceid enhance efferocytosis by increasing the secretion of MFG-E8 in human THP-1 macrophages., PMID:38830798
Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis., PMID:38802814
COMT Variants are Associated With Breast and Nipple Pain., PMID:38763257
Correlation of Serum and Gingival Crevicular Fluid Levels of Caspase-3 and Milk Fat Globule-Epidermal Growth Factor 8 on Gingival Health., PMID:38739812
TAG-FREE GLYCOSYLATED RHMFG-E8 AS A THERAPY FOR ACUTE KIDNEY INJURY., PMID:38691106
Identification of chemoresistance associated key genes-miRNAs-TFs in docetaxel resistant breast cancer by bioinformatics analysis., PMID:38590544
The Novel MFG-E8-derived Oligopeptide, MOP3, Improves Outcomes in a Preclinical Murine Model of Neonatal Sepsis., PMID:38582704
MFGE8 in exosomes derived from mesenchymal stem cells prevents esophageal stricture after endoscopic submucosal dissection in pigs., PMID:38561800
For research use only. Not for human or drug use.
