Catalog No.
YHG08901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala41-Gln222
Predicted molecular weight
21.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q06418
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RSE, TYRO3, Tyrosine-protein kinase TIF, Tyrosine-protein kinase RSE, BYK, Tyrosine-protein kinase BYK, DTK, TIF, Tyrosine-protein kinase DTK, SKY, Tyrosine-protein kinase SKY, Tyrosine-protein kinase receptor TYRO3
Cerebrospinal Fluid Biomarkers in Opioid Dependence: Evidence of Neuroimmune Activation and Ion Composition Changes, Without Alteration in Orexin-A., PMID:40454659
Structure-Based Design of Potent and Selective MerTK Inhibitors by Modulating the Conformation of αC Helix., PMID:40391976
Recent advances in TAM mechanisms in lung diseases., PMID:40287707
Sex hormone-binding globulin dampens growth and metastasis of breast cancer in an estrogen-independent manner., PMID:40241272
Discovery of Novel TYRO3/MERTK Dual Inhibitors., PMID:40215328
Increased independent ingestion in Anorexia (anx) mutant mice., PMID:40203962
Comprehensive Molecular and Genomic Analysis of NCI-MATCH Subprotocol Y: Capivasertib in Patients With an AKT1 E17K-Mutated Tumor., PMID:40153687
Navigating TAM receptor dynamics in tumour immunotherapy., PMID:40088262
UNC9426, a Potent and Orally Bioavailable TYRO3-Specific Inhibitor., PMID:40070132
A single mutation in the PrM gene of Zika virus determines AXL dependency for infection of human neural cells., PMID:40062839
Proteolysis of TAM receptors in autoimmune diseases and cancer: what does it say to us?, PMID:40044635
Vitamin K supports TGF-β1 depended in vitro human Langerhans cell differentiation and function via Axl., PMID:40040711
Activated AXL Ameliorates Alcohol-associated Steatotic Liver Ischemia-Reperfusion Injury by Inhibiting ER stress and Mitochondria-associated Apoptosis., PMID:39897049
New potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis., PMID:39892997
Distinct TYRO3 and PROS1 expression levels contribute to preeclampsia pathogenesis., PMID:39878883
Phytochemicals Withanolide N and Dryobalanolide as Potential Bioactive Leads for Developing Anticancer Drugs Targeting Tyrosine-Protein Kinase Mer., PMID:39792454
Lower Circulating Gas6 Levels Are Associated with Bulbar Phenotype and Faster Disease Progression in Amyotrophic Lateral Sclerosis Patients., PMID:39762711
Nuclear Factor Erythroid 2-Related Factor 2 Activator DDO-1039 Ameliorates Podocyte Injury in Diabetic Kidney Disease via Suppressing Oxidative Stress, Inflammation, and Ferroptosis., PMID:39723566
Uncovering the molecular networks of ferroptosis in the pathogenesis of type 2 diabetes and its complications: a multi-omics investigation., PMID:39716081
Functions of TAM Receptors and Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease., PMID:39684449
TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury., PMID:39680199
Tyro3 and Gas6 are associated with white matter and myelin integrity in multiple sclerosis., PMID:39673059
Design and Development of Novel Hybrids Based on Pyrrolo[2,1-f][1,2,4]Triazine and 1-(Methylpiperidin-4-yl) Aniline-Based Analogs: Exploring the Utility as Anticancer Agents via MERTK Inhibition., PMID:39635932
Role and Mechanisms of Tyro3 in Podocyte Biology and Glomerular Disease., PMID:39430290
Germline DNA Damage Repair Gene Alterations in Patients with Metachronous Breast and Colorectal Cancer., PMID:39408606
TYRO3 and EPHA2 Expression Are Dysregulated in Breast Cancer., PMID:39327735
MERTK inhibition selectively activates a DC - T-cell axis to provide anti-leukemia immunity., PMID:39322710
GAS6 as a potential target to alleviate neuroinflammation during Japanese encephalitis in mouse models., PMID:39300526
The protective role of Mertk in JEV-induced encephalitis by maintaining the integrity of blood-brain barrier., PMID:39277738
The transcription factors NR5A1 and JUNB cooperate to activate the Axl promoter in mouse Sertoli cell lines., PMID:39271559
SAFFRON-104: a phase Ib/II study of sitravatinib alone or with tislelizumab in advanced hepatocellular carcinoma and gastric cancer/gastroesophageal junction cancer., PMID:39235596
E3 ubiquitin ligase BTBD3 inhibits tumorigenesis of colorectal cancer by regulating the TYRO3/Wnt/β-catenin signaling axis., PMID:39227913
Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours., PMID:39179860
Hallmarks of pancreatic cancer: spotlight on TAM receptors., PMID:39137571
MERTK Inhibition as a Targeted Novel Cancer Therapy., PMID:39062902
PGC1α enhances macrophage efferocytosis in ox-LDL-stimulated RAW264.7 cells by regulating the NLRP3/PPARα axis., PMID:39047550
GAS6 and AXL Promote Insulin Resistance by Rewiring Insulin Signaling and Increasing Insulin Receptor Trafficking to Endosomes., PMID:39046834
Elevated Plasma Levels of Growth Arrest Specific 6 (Gas6) Protein in Severe Obesity: Implications for Adipose Tissue and Inflammation., PMID:38932442
Gas6 and Protein S Ligands Cooperate to Regulate MerTK Rhythmic Activity Required for Circadian Retinal Phagocytosis., PMID:38928335
Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma., PMID:38906855
In the Eyes of the Beholder-New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK., PMID:38791338
Gas6/TAM system as potential biomarker for multiple sclerosis prognosis., PMID:38745659
Gas6/AXL Alleviates Hepatic Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the PI3K/AKT Pathway., PMID:38725107
Immunological role of Gas6/TAM signaling in hemostasis and thrombosis., PMID:38723521
Phosphatidylserine and Tyro3-Axl-Mertk Receptor Tyrosine Kinase level detection in plasma and on plasma-derived extracellular vesicle surface in chronic lymphocytic leukemia., PMID:38715180
De Novo Multi-Omics Pathway Analysis Designed for Prior Data Independent Inference of Cell Signaling Pathways., PMID:38703893
The Vitamin K-Dependent Anticoagulant Factor, Protein S, Regulates Vascular Permeability., PMID:38666935
Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury., PMID:38653371
Duodenal mucosa of untreated celiac disease patients has altered expression of the GAS6 and PROS1 and the negative regulator tyrosine kinase TAM receptors subfamily., PMID:38575045
The therapeutic effect of GAS6 in remyelination is dependent upon Tyro3., PMID:38572807
For research use only. Not for human or drug use.
