Catalog No.
YHG04601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln152-Asp496
Predicted molecular weight
41.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q05329
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Glutamate decarboxylase 2, GAD65, 65 kDa glutamic acid decarboxylase, GAD-65, GAD2, Glutamate decarboxylase 65 kDa isoform
Molecular signatures of regional vulnerability to tauopathy in excitatory cortical neurons., PMID:40481857
The mRNA-binding protein HLN1 enhances drought stress tolerance by stabilizing the GAD2 mRNA in Arabidopsis., PMID:40478352
Research on the Improvement Effects and Mechanisms of Magnolia sieboldii Essential Oils on Insomnia in Mice., PMID:40443218
Longitudinal EEG Characteristics of Anti-GAD65 Antibody Related Autoimmune Epilepsy., PMID:40368330
Clinical Features and Outcomes of Glutamic Acid Decarboxylase-65 Antibody-Associated Pure Cerebellar Ataxia and Stiff Person Syndrome Spectrum Disorders: A Single-Center Cohort Study., PMID:40342250
Anxa10 and neuropathic pain: Insights into dysregulation of endoplasmic reticulum-mitochondria contact tethering complex and therapeutic potential., PMID:40250776
Curcumin reduces pain after spinal cord injury in rats by decreasing oxidative stress and increasing GABAA receptor and GAD65 levels., PMID:40234536
Pterostilben upregulates GAD67-mediated GABA synthesis in hippocampal parvalbumin-positive cells., PMID:40189131
Comprehensive analysis of eccDNA characteristics and associated genes expression in peripheral blood of ASLE and ISLE patients., PMID:40108975
Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody., PMID:40055307
NGF regulates survival and differentiation of umbilical mesenchymal stem/stromal cells into GABAergic, dopaminergic and cholinergic lineages., PMID:40010415
Upper motor neuron-predominant motor neuron disease: a novel immunotherapy-responsive association of GAD65 autoimmunity., PMID:39998694
Islet autoantibodies in Thai individuals diagnosed with type 1 diabetes before 30 years of age: a large multicentre nationwide study., PMID:39971754
CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model., PMID:39894446
The IVIG treatment response in autoimmune polyendocrine syndromes type 2 with anti-GAD65 antibody-associated stiff person syndrome: a case report and literature review., PMID:39840065
Anti-GAD65 musicogenic epilepsy: Bilateral and independent mesial temporal seizures revealed by foramen ovale electrodes., PMID:39835722
Whole-Genome Sequence Analysis of Flammulina filiformis and Functional Validation of Gad, a Key Gene for γ-Aminobutyric Acid Synthesis., PMID:39728358
Ndufs4 inactivation in glutamatergic neurons reveals swallow-breathing discoordination in a mouse model of Leigh syndrome., PMID:39710245
Neuronal growth regulator 1 (NEGR1) promotes the synaptic targeting of glutamic acid decarboxylase 65 (GAD65)., PMID:39676071
Glutamic Acid Decarboxylase 65 Antibody-associated Epilepsy and Diplopia: Two Case Reports with Literature Review., PMID:39658688
PAX6 is a useful marker for pancreatic origin of neuroendocrine neoplasms: A tissue microarray study evaluating more than 19,000 tumors from 150 different tumor types., PMID:39571690
Preclinical Development of a Tolerogenic Peptide From Glutamate Decarboxylase as a Candidate for Antigen-Specific Immunotherapy in Type 1 Diabetes., PMID:39571092
Autoimmune encephalitis with coexisting antibodies to GABABR, GAD65, SOX1 and Ma2., PMID:39538282
Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes., PMID:39472557
SNAP25-induced MYC upregulation promotes high-grade neuroendocrine lung carcinoma progression., PMID:39430761
CSF and blood signatures support classification of limbic encephalitis subtypes., PMID:39401553
Dorsomedial Ventromedial Hypothalamic Nucleus Growth Hormone-Releasing Hormone Neuron Steroidogenic Factor-1 Gene Targets in Female Rat., PMID:39401164
Schizophrenia-associated changes in neuronal subpopulations in the human midbrain., PMID:39397771
Acupuncture improves neuroendocrine defects in a preclinical rat model of reproductive aging., PMID:39366551
Unveiling proteomic targets in the hypothalamus of ovariectomized and estradiol-treated rats: Insights into menopausal syndrome mechanisms., PMID:39326767
LNP-mRNA vaccine prevents type 1 diabetes in non-obese diabetes mice., PMID:39278354
GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel., PMID:39277606
High-nitrogen-induced γ-aminobutyric acid triggers host immunity and pathogen oxidative stress tolerance in tomato and Ralstonia solanacearum interaction., PMID:39253785
Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor and GAD65 Antibodies: Case Report and Potential Mechanisms., PMID:39213470
Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications., PMID:39210294
Spectrum of neurological manifestations, existence of diabetes mellitus, and 5-year mortality and cancer association outcomes in a cohort of Omani patients with positive anti- GAD autoimmunity., PMID:39167450
Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes., PMID:39163201
IT-DEX and B cell depletion in a child with anti-GAD 65 autoimmune encephalitis presenting as NORSE: A case report., PMID:39128431
Outcomes of surgical resection and vagus nerve stimulation in patients with medically refractory epilepsy and glutamic acid decarboxylase 65 antibody positivity., PMID:39110151
Machine learning characterization of a rare neurologic disease via electronic health records: a proof-of-principle study on stiff person syndrome., PMID:39097681
Management of autoimmune temporal lobe epilepsy with GAD65 antibody: four case reports., PMID:39093166
Editors' Note: Recurrent Rhombencephalitis Associated With Anti-GAD65 Antibody., PMID:39083754
Reader Response: Recurrent Rhombencephalitis Associated With Anti-GAD65 Antibody., PMID:39083716
Reader Response: Recurrent Rhombencephalitis Associated With Anti-GAD65 Antibody., PMID:39083702
Neurophysiological, structural, and molecular alterations in the prefrontal and auditory cortices following noise-induced hearing loss., PMID:39079581
Steroidogenic Factor-1 Regulation of Dorsomedial Ventromedial Hypothalamic Nucleus Ghrh Neuron Transmitter Marker and Estrogen Receptor Gene Expression in Male Rat., PMID:39024550
Exploring microbiota-gut-brain axis biomarkers linked to autism spectrum disorder in prenatally chlorpyrifos-exposed Fmr1 knock-out and wild-type male rats., PMID:38925359
HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes., PMID:38909044
Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway., PMID:38908492
Glucose transporter-2 regulation of VMN GABA neuron metabolic sensor and transmitter gene expression., PMID:38902332
For research use only. Not for human or drug use.
