Catalog No.
YHG04301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu293
Predicted molecular weight
36.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q05209
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PTPG1, PTPN12, PTP-PEST, Tyrosine-protein phosphatase non-receptor type 12, Protein-tyrosine phosphatase G1
Dual Conjugation of Long- and Medium-Chain Fatty Acids to BimBH3 Peptide Yields Ultra Long-Acting Inhibitors of Intracellular PTPN1/2., PMID:40458949
Mutational and expression analysis of classical protein tyrosine phosphatase genes in pancreatic ductal adenocarcinoma., PMID:40403635
Structure of the phosphocysteine intermediate of the phosphatase of regenerating liver PTP4A1., PMID:40398601
miR-369-3p regulates the drug resistance of lung cancer cells by targeting PTPN12., PMID:40366733
Biochemical and Structural Studies of Protein Tyrosine Phosphatase PTP-PEST (PTPN12) in Search of Small Molecule Inhibitors., PMID:39895370
Immobile Integrin Signaling Transit and Relay Nodes Organize Mechanosignaling through Force-Dependent Phosphorylation in Focal Adhesions., PMID:39760672
Abl kinases regulate FGF signaling independent of Crk phosphorylation to prevent Peters anomaly., PMID:39484567
PTPN1/2 inhibition promotes muscle stem cell differentiation in Duchenne muscular dystrophy., PMID:39477543
The de-sulfinylation enzyme sulfiredoxin-1 attenuates hepatic stellate cell activation and liver fibrosis by modulating the PTPN12-NLRP3 axis., PMID:39446334
ESRP1-mediated biogenesis of circPTPN12 inhibits hepatocellular carcinoma progression by PDLIM2/ NF-κB pathway., PMID:38992675
C-terminally phosphorylated p27 activates self-renewal driver genes to program cancer stem cell expansion, mammary hyperplasia and cancer., PMID:38886396
Identification of PTPN12 Phosphatase as a Novel Negative Regulator of Hippo Pathway Effectors YAP/TAZ in Breast Cancer., PMID:38612874
Nano-clusters of ligand-activated integrins organize immobile, signalling active, nano-clusters of phosphorylated FAK required for mechanosignaling in focal adhesions., PMID:38464288
Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma., PMID:37563735
PTPN12 down-regulated by miR-146b-3p gene affects the malignant progression of laryngeal squamous cell carcinoma., PMID:37333450
RNA-Seq Comprehensive Analysis Reveals the Long Noncoding RNA Expression Profile and Coexpressed mRNA in Adult Degenerative Scoliosis., PMID:36035195
Depletion of circ_0128846 ameliorates interleukin-1β-induced human chondrocyte apoptosis and inflammation through the miR-940/PTPN12 pathway., PMID:35978501
Critical roles of PTPN family members regulated by non-coding RNAs in tumorigenesis and immunotherapy., PMID:35957898
Tumor Suppressor DAPK1 Catalyzes Adhesion Assembly on Rigid but Anoikis on Soft Matrices., PMID:35927990
Transthyretin-induced increase in circ_0007411 represses neovascularization of human retinal microvascular endothelial cells in hyperglycemia via the miR-548m/PTPN12/SKP1/EGFR pathway., PMID:35722376
SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding., PMID:35393453
LncRNA GATA2-AS1 suppresses esophageal squamous cell carcinoma progression via the mir-940/PTPN12 axis., PMID:35364057
Downregulation of secreted frizzled-related protein 4 inhibits hypoxia/reoxygenation injury in diabetic cardiomyocytes by protein tyrosine phosphatase nonreceptor type 12., PMID:35290144
Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family., PMID:35192416
Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells., PMID:35136055
Protein tyrosine phosphatase non-receptor type 12 suppresses tumor progression in osteosarcoma cells., PMID:35063332
PTP-PEST Regulated Membranous/Cytoplasmic Translocation of p120ctn in the Lung Cancer Resistance to Tyrosine Kinase Inhibitor., PMID:35030104
Evaluating Large Spontaneous Deletions in a Bovine Cell Line Selected for Bovine Viral Diarrhea Virus Resistance., PMID:34834954
Protein tyrosine phosphatase non-receptor type 12 (PTPN12), negatively regulated by miR-106a-5p, suppresses the progression of hepatocellular carcinoma., PMID:34784010
Role of the F-BAR Family Member PSTPIP2 in Autoinflammatory Diseases., PMID:34262554
circPTPN12/miR-21-5 p/∆Np63α pathway contributes to human endometrial fibrosis., PMID:34132637
Spatially interacting phosphorylation sites and mutations in cancer., PMID:33875650
High expression of MAPK-14 promoting the death of chondrocytes is an important signal of osteoarthritis process., PMID:33520453
The protein tyrosine phosphatase PTP-PEST mediates hypoxia-induced endothelial autophagy and angiogenesis via AMPK activation., PMID:33323505
Expression and clinical significance of PTPN12 in clear cell renal cell carcinoma., PMID:33292053
Expression Analysis of Tyrosine Phosphatase Genes at Different Stages of Renal Cell Carcinoma., PMID:32988891
A fluorescent probe for monitoring PTP-PEST enzymatic activity., PMID:32812952
Progress in the correlation between PTPN12 gene expression and human tumors., PMID:32541467
The expression patterns and the diagnostic/prognostic roles of PTPN family members in digestive tract cancers., PMID:32536826
Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics., PMID:32501498
Nonreceptor protein tyrosine phosphatases (NRPTPs) gene family associates with the risk of hepatocellular carcinoma in a Chinese hepatitis B virus-related subjects., PMID:32484301
Candidate genes for hereditary colorectal cancer: Mutational screening and systematic review., PMID:32449991
High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer., PMID:31606028
Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia., PMID:31542223
MicroRNA-503 serves an oncogenic role in retinoblastoma progression by directly targeting PTPN12., PMID:31410179
Targeting protein tyrosine phosphatase PTP-PEST (PTPN12) for therapeutic intervention in acute myocardial infarction., PMID:31228185
Clinical implications of a novel prognostic factor AIFM3 in breast cancer patients., PMID:31088422
Important roles of protein tyrosine phosphatase PTPN12 in tumor progression., PMID:30959160
A missense variant in PTPN12 associated with the risk of colorectal cancer by modifying Ras/MEK/ERK signaling., PMID:30731403
Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A., PMID:30344108
For research use only. Not for human or drug use.
