Catalog No.
YHG01001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln220
Predicted molecular weight
27.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q04206
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, Transcription factor p65, NFKB3
SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging., PMID:40513569
Asthma and COPD Beyond the Airways: Exploring Neurocognitive Links Through NF-κB Subunits c-Rel and p65., PMID:40508027
The Role of Sirt1 in Regulating Inflammatory Cytokines and Oxidative Stress in the Transition Mechanism from Depressive Disorder to Alzheimer's Disease., PMID:40490662
Lobetyolin Suppressed Osteoclastogenesis and Alleviated Bone Loss in Ovariectomy-Induced Osteoporosis via Hindering p50/p65 Nuclear Translocation and Downstream NFATc1/c-Fos Expression., PMID:40486125
[Polysaccharide extract PCP1 from Polygonatum cyrtonema ameliorates cerebral ischemia-reperfusion injury in rats by inhibiting TLR4/NLRP3 pathway]., PMID:40461201
Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expression of inflammation genes., PMID:40446041
RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners., PMID:40442479
Uncovering the molecular mechanisms of tonifying kidney and activating blood Decoction against myocardial fibrosis using network Pharmacology and experimental validation., PMID:40442166
Unveiling Isorhapontigenin's therapeutic potential in lung cancer via integrated network pharmacology, molecular docking, and experimental validation., PMID:40442126
Tumor-associated macrophages contribute to cisplatin resistance via regulating Pol η-mediated translesion DNA synthesis in ovarian cancer., PMID:40437303
Dihydrotestosterone and 17β-estradiol modulate TMJ osteoarthritis development and reveal sex-specific differences in pathogenesis., PMID:40437041
Investigating the RelA Gene's role in African Swine fever tolerance: a study of Indian pigs., PMID:40436218
Identification of biomarkers associated with inflammatory response in Parkinson's disease by bioinformatics and machine learning., PMID:40435035
Activating Transcription Factor 3 (ATF3) Regulates Cellular Senescence and Osteoclastogenesis via STAT3/ERK and p65/AP-1 Pathways in Human Periodontal Ligament Cells., PMID:40430099
Computational Modeling of Network Topology and Molecular Dynamics for the Assessment of Therapeutic Potential of the Astragalus Membranaceus-Salvia Miltiorrhiza Drug Pair in the Treatment of Chronic Kidney and Heart Failure., PMID:40424487
Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice., PMID:40416970
Nesfatin-1 Suppresses Inflammation in Bronchopulmonary Dysplasia by Regulating HMGB-1/TLR4/p65/NLRP3 Signaling Pathway., PMID:40415368
Mechanistic insights into NETs-induced osteogenesis inhibition in BMSCs of rheumatoid arthritis., PMID:40414474
Screening, Analysis, and Validation of Endoplasmic Reticulum Stress-Related DEGs in Epilepsy., PMID:40413658
Selenoprotein K-dependent MyD88 palmitoylation promotes hepatic metaflammation in high-fat diet fed mice., PMID:40409695
Single-cell sequencing and transcriptomic data reveal that P65 activation significantly promotes microglia-mediated neuroinflammation after ischemic stroke., PMID:40404711
Dissecting the shared molecular mechanisms underlying polycystic ovary syndrome and schizophrenia etiology: a translational integrative approach., PMID:40387450
Physiological roles of an Acinetobacter-specific σ factor., PMID:40387328
In Silico and In Vivo Pharmacological Study of Acmella paniculata Flowers for Anti-Inflammatory and Antiarthritic Potential., PMID:40387128
[Report and literature review of a familial case of autoinflammatory disease associated with RELA gene variant]., PMID:40372226
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses., PMID:40367949
EGFR/STAT3 signaling mediates the upregulation of CD47 in HPV-positive cervical cancer by activating p65 and exosome transporter RAB31., PMID:40353624
Transcriptomic analysis reveals potential biomarkers for early-onset pre-eclampsia using integrative bioinformatics and LASSO based approach., PMID:40347801
SDC4 identified as an oncogenic target gene of NF-κB in TNFα-Induced tumor cells., PMID:40341546
Genetic Blueprint for Stringent Response in Betaproteobacterial Aromatoleum/Azoarcus/Thauera Cluster., PMID:40334648
Effect of Cudrania tricuspidata on Cariogenic Properties and Caries-Related Gene Expression in Streptococcus mutans., PMID:40333726
A Survey for Human Tissue-Level Determinants of CAV1 Regulation and Function., PMID:40332409
PINK1-dependent NFKB signaling contributes to amyloid pathology in Alzheimer disease., PMID:40320714
Identification of Endoplasmic Reticulum Stress-Related Genes in Acute Myocardial Infarction: A Bioinformatics Approach with Experimental Validation., PMID:40319218
Identification of potential anti aging drugs and targets in chronic kidney disease., PMID:40319112
Neferine inhibits PRRSV infection by disrupting p65 nuclear translocation., PMID:40311944
Chromatin-associated cullin-RING E3 ubiquitin ligases: keeping transcriptionally active NF-κB in check., PMID:40308609
Comparative Analysis of Virulence Genes in Non-Tuberculosis Mycobacteria (NTM) Isolated from Kenyan Camel Milk Suggests Potential Pathogenicity., PMID:40304757
Downregulation of A20 Expression Related to T Cells by Staphylococcal Enterotoxin A Treatment., PMID:40299129
[Aurora-A overexpression promotes cervical cancer cell invasion and metastasis by activating the NF-κBp65/ARPC4 signaling axis]., PMID:40294934
Exploring the anti-inflammatory activity of fupenzic acid using network pharmacology and experimental validation., PMID:40274978
Shenfu injection alleviates lipopolysaccharide-induced liver injury in septic mice., PMID:40263344
DKS26 Alleviates Ischemia-Reperfusion Injury-Induced Acute Kidney Injury by Stabilizing Vitamin D Receptors to Inhibit the Inflammatory Pathway of NF-κB P65., PMID:40243616
Treg Cells Attenuate Pulmonary Venous Remodeling in PH-LHD via NLRC3 Signaling., PMID:40235449
Transcription factor occupancy limits DNA methylation and determines ICAM1 expression in breast cancer., PMID:40230289
Taurine ameliorates liver fibrosis by repressing Fpr2-regulated macrophage M1 polarization., PMID:40216178
ALKBH5 Improves the Epithelial Cell Tight Junctions to Inhibit Escherichia coli-Induced Mastitis., PMID:40214476
Identification and validation of five novel protein targets for type 2 diabetes mellitus., PMID:40204939
Taraxacum mongolicum Hand.-Mazz. extract disrupts the interaction between triple-negative breast cancer cells and tumor-associated macrophages by inhibiting RAC2/NF-κB p65/p38 MAPK pathway., PMID:40199407
Liraglutide attenuates high glucose-induced endothelial cell senescence and dysfunction via SIRT1-mediated deacetylation of p53/p65., PMID:40198926
For research use only. Not for human or drug use.
