Catalog No.
YHF99301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala28-Gly188
Predicted molecular weight
20.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q03431
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTHR1, PTHR, PTH1 receptor, PTH/PTHrP type I receptor, PTH1R, Parathyroid hormone/parathyroid hormone-related peptide receptor
Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis., PMID:40501563
Unraveling the molecular landscape of congenital pseudoarthrosis of the tibia: insights from a comprehensive analysis of 159 probands., PMID:40462134
A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics., PMID:40455993
Loss-of-function Gαs rare disease variants exert mutation-specific effects on GPCR signaling., PMID:40392940
Extracellular ATP increases agonist potency and reduces latency at class B G protein-coupled receptors., PMID:40378650
Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors., PMID:40307870
Decoding migraine disorders: parathyroid hormone-related peptide receptors as key genetic drivers., PMID:40297711
Mandibular Condylar Cartilage in Development and Diseases: A PTHrP-Centric View., PMID:40251915
Dimeric R25CPTH(1-34) activates the parathyroid hormone-1 receptor in vitro and stimulates bone formation in osteoporotic female mice., PMID:40153305
Allosteric mechanism in the distinctive coupling of Gq and Gs to the parathyroid hormone type 1 receptor., PMID:40138341
Variants in WASHC3, a component of the WASH complex, cause short stature, variable neurodevelopmental abnormalities, and distinctive facial dysmorphism., PMID:40129681
Syndromic and Non-Syndromic Primary Failure of Tooth Eruption: A Genetic Overview., PMID:40004475
A novel PTH1R mutation causes primary failure of eruption via the cAMP-PI3K/AKT pathway., PMID:39988614
Jansen's disease: bone abnormalities beyond chondrodysplasia., PMID:39950977
Key Interaction Changes Determine the Activation Process of Human Parathyroid Hormone Type 1 Receptor., PMID:39804793
Negative feedback between PTH1R and IGF1 through the Hedgehog pathway in mediating craniofacial bone remodeling., PMID:39688917
PTH1R Suppressed Apoptosis of Mesenchymal Progenitors in Mandibular Growth., PMID:39684319
Histological assessments for anabolic effects in teriparatide/abaloparatide administered rodent models., PMID:39630261
Fast-diffusing receptor collisions with slow-diffusing peptide ligand assemble the ternary parathyroid hormone-GPCR-arrestin complex., PMID:39627206
Hydrophobic ion pairing as a novel approach to co-axial electrospraying of peptide-PLGA particles., PMID:39491655
Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling., PMID:39376604
New Insight into the genotype-phenotype correlation of PTH1R variants and primary failure of tooth eruption on an Italian Cohort., PMID:39327493
Eiken syndrome with parathyroid hormone resistance due to a novel parathyroid hormone receptor type 1 mutation: clinical features and functional analysis., PMID:39276366
Mechanoinduction of PTHrP/cAMP-signaling governs proteoglycan production in mesenchymal stromal cell-derived neocartilage., PMID:39238313
Erratum for the Research Article "A β-Arrestin-Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation" by D. Gesty-Palmer et al., PMID:39141704
High-Throughput Preosteoblastic Spheroids Elevate Fibroblast Growth Factor 23 via Parathyroid Hormone Signaling Pathway., PMID:39109940
Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors., PMID:39039165
PTH receptor signalling, osteocytes and bone disease induced by diabetes mellitus., PMID:39020007
Regulation of intracellular cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase via PDE8A., PMID:38979143
Romosozumab versus parathyroid hormone receptor agonists: which osteoanabolic to choose and when?, PMID:38938063
Etiological Mechanisms and Genetic/Biological Modulation Related to PTH1R in Primary Failure of Tooth Eruption., PMID:38833001
Highly biased agonism for GPCR ligands via nanobody tethering., PMID:38824166
Biological changes in human B-cell line Ramos (RA.1) related to increasing doses of human parathyroid hormone., PMID:38770298
Rare genetic disorders that impair parathyroid hormone synthesis, secretion, or bioactivity provide insights into the diagnostic utility of different parathyroid hormone assays., PMID:38701324
Claudin-10 Expression and the Gene Expression Pattern of Thick Ascending Limb Cells., PMID:38612818
An Open-label Phase 2 Study of Eneboparatide, a Novel PTH Receptor 1 Agonist, in Hypoparathyroidism., PMID:38449442
Transcriptome Analysis Identifies Tumor Immune Microenvironment Signaling Networks Supporting Metastatic Castration-Resistant Prostate Cancer., PMID:38435029
Parathyroid hormone-PTH1R signaling in cardiovascular disease and homeostasis., PMID:38429163
Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants., PMID:38417010
Abaloparatide is more potent than teriparatide in restoring bone mass and strength in type 1 diabetic male mice., PMID:38360197
Serum Olink Proteomics-Based Identification of Protein Biomarkers Associated with the Immune Response in Ischemic Stroke., PMID:38319990
Unraveling the Interplay of Extracellular Domain Conformational Changes and Parathyroid Hormone Type 1 Receptor Activation in Class B1 G Protein-Coupled Receptors: Integrating Enhanced Sampling Molecular Dynamics Simulations and Markov State Models., PMID:38314550
Primary Failure of Dental Eruption Due to Variants Parathyroid Hormone Receptor 1: Retrospective Study and Proposal of Guidelines Treatment., PMID:38299863
Pth1r in Neural Crest Cells Regulates Nasal Cartilage Differentiation., PMID:38234039
Systems genetics and bioinformatics analyses using ESR1-correlated genes identify potential candidates underlying female bone development., PMID:38141931
The pathophysiology of hypophosphatemia., PMID:38087658
Whole genome sequencing in families with oligodontia., PMID:38071191
A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2., PMID:38058151
Combined signature of G protein-coupled receptors and tumor microenvironment provides a prognostic and therapeutic biomarker for skin cutaneous melanoma., PMID:38006451
For research use only. Not for human or drug use.
