Catalog No.
YHF92201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala256-Lys582
Predicted molecular weight
39.57 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q02218
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Alpha-ketoglutarate dehydrogenase, OGDC-E1, OGDH, 2-oxoglutarate dehydrogenase complex component E1, 2-oxoglutarate dehydrogenase, mitochondrial
Bioinformatics-led identification of pathophysiological hallmark genes in diabesotension via graph clustering method., PMID:40491693
Circular RNA-OGDH Promotes PANoptosis in Diabetic Cardiomyopathy: A Novel Mechanistic Insight., PMID:40412523
Metabolic Effects of the Cancer Metastasis Modulator MEMO1., PMID:40278406
Identification of Biomarkers for Meat Quality in Sichuan Goats Through 4D Label-Free Quantitative Proteomics., PMID:40150416
Influencing factors and quality traits of pigeon meat: A systematic review., PMID:40068574
Primary metabolomics and transcriptomic techniques were used to explore the regulatory mechanisms that may influence the flavor characteristics of fresh Corylus heterophylla × Corylus avellana., PMID:39949634
The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism., PMID:39889707
Modified Shenqi Dihuang Decoction inhibits prostate cancer metastasis by disrupting TCA cycle energy metabolism via NF-kB/p65-mediated OGDH regulation., PMID:39848017
PINK1 is a target of T cell responses in Parkinson's disease., PMID:39688918
Reverse phase protein array-based investigation of mitochondrial genes reveals alteration of glutaminolysis in the parahippocampal cortex of people who died by suicide., PMID:39604371
Unravelling the molecular regulation network of carbon metabolism and lipid metabolism during seed development in Akebia trifoliata via integrated multi-omics analysis., PMID:39358430
α-Ketoglutarate promotes cardiomyocyte proliferation and heart regeneration after myocardial infarction., PMID:39223390
Combined High-Throughput Proteomics and Random Forest Machine-Learning Approach Differentiates and Classifies Metabolic, Immune, Signaling and ECM Intra-Tumor Heterogeneity of Colorectal Cancer., PMID:39195201
Combining transcriptomics and HPLC to uncover variations in quality formation between 'Benihoppe' and 'Fenyu No.1' strawberries., PMID:39181084
Integrative Proteomics-Metabolomics of In Vitro Degeneration of Cardiovascular Cell Lines., PMID:39110328
Tankyrase1/2 inhibitor XAV-939 reverts EMT and suggests that PARylation partially regulates aerobic activities in human hepatocytes and HepG2 cells., PMID:39053638
A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens., PMID:38969985
Methylated urolithin A, mitigates cognitive impairment by inhibiting NLRP3 inflammasome and ameliorating mitochondrial dysfunction in aging mice., PMID:38636727
OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma., PMID:38483541
PINK1 is a target of T cell responses in Parkinson's disease., PMID:38405939
The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia., PMID:38266099
Spinal cord abnormal autophagy and mitochondria energy metabolism are modified by swim training in SOD1-G93A mice., PMID:38197966
Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity., PMID:38031187
Glutamate decarboxylase-1 is essential for efficient acclimation of Arabidopsis thaliana to nutritional phosphorus deprivation., PMID:37837235
ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control., PMID:37742191
Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis., PMID:37678921
Role of OGDH in Atophagy-IRF3-IFN-β pathway during classical swine fever virus infection., PMID:37604413
Transcriptome profiling of A549 non-small cell lung cancer cells in response to Trichinella spiralis muscle larvae excretory/secretory products., PMID:37601754
FDX1 regulates cellular protein lipoylation through direct binding to LIAS., PMID:37453661
Subunit composition of mitochondrial dehydrogenase complexes in diplonemid flagellates., PMID:37451476
The oxoglutarate dehydrogenase complex is involved in myofibril growth and Z-disc assembly in Drosophila., PMID:37272588
The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis., PMID:37221841
L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis., PMID:36879117
[Expression of Key Enzymes in Glucose Metabolism in Chronic Mountain Sickness and Its Correlation with Phenotype]., PMID:36765499
Total coumarins of Pileostegia tomentella induces cell death in SCLC by reprogramming metabolic patterns, possibly through attenuating β-catenin/AMPK/SIRT1., PMID:36597133
Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities., PMID:36520152
Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation., PMID:36460681
Identification of core genes in prefrontal cortex and hippocampus of Alzheimer's disease based on mRNA-miRNA network., PMID:36401602
The Brain Protein Acylation System Responds to Seizures in the Rat Model of PTZ-Induced Epilepsy., PMID:36293175
Changes in the Expression of MIF and Other Key Enzymes of Energy Metabolism in the Myocardia of Broiler Chickens with Ascites Syndrome., PMID:36230229
Distinct proteomic profiles in prefrontal subareas of elderly major depressive disorder and bipolar disorder patients., PMID:35821008
Xanthomonas oryzae Pv. oryzicola Response Regulator VemR Is Co-opted by the Sensor Kinase CheA for Phosphorylation of Multiple Pathogenicity-Related Targets., PMID:35756024
Delayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the Rat Brain Metabolism Is Linked to Protein Glutarylation., PMID:35721081
Tandem Mass Tagging (TMT) Reveals Tissue-Specific Proteome of L4 Larvae of Anisakis simplex s. s.: Enzymes of Energy and/or Carbohydrate Metabolism as Potential Drug Targets in Anisakiasis., PMID:35457153
The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry., PMID:34728602
Citrate Synthase and OGDH as Potential Biomarkers of Atherosclerosis under Chronic Stress., PMID:34539976
Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection., PMID:34534287
Acetate Promotes a Differential Energy Metabolic Response in Human HCT 116 and COLO 205 Colon Cancer Cells Impacting Cancer Cell Growth and Invasiveness., PMID:34414111
Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis., PMID:34246305
The Impaired Bioenergetics of Diabetic Cardiac Microvascular Endothelial Cells., PMID:34054724
For research use only. Not for human or drug use.
