Catalog No.
YHF91801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr31-Arg395
Predicted molecular weight
41.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q02127
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dihydroorotate oxidase, Dihydroorotate dehydrogenase (quinone), mitochondrial, DHODH, DHOdehase
DHODH blockade induces ferroptosis in neuroblastoma by modulating the mevalonate pathway., PMID:40513779
A Metal-Phenolic Network Nanoresensitizer Overcoming Glioblastoma Drug Resistance through the Metabolic Adaptive Strategy and Targeting Drug-Tolerant Cells., PMID:40489242
The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b., PMID:40460517
Inner-mitochondrial membrane protein PfMPV17 is linked to P. falciparum in vitro resistance to the indoloquinolizidine alkaloid alstonine., PMID:40432501
Isolation and validation of antimalarial compounds from Phyllanthus emblica leaves for new antimalarial drug development., PMID:40394223
Not Once, not Twice, but Thrice: Structure and Catalytic Mechanisms of the Dihydroorotate Dehydrogenases., PMID:40371914
Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells., PMID:40354545
Exploring the Anti-Chagas Activity of Zanthoxylum chiloperone's Seedlings Through Metabolomics and Protein-Ligand Docking., PMID:40265836
Natural products protect against spinal cord injury by inhibiting ferroptosis: a literature review., PMID:40248093
Discovery of a New Class of Thiazolidin-4-one-Based Inhibitors of Human Dihydroorotate Dehydrogenase: Biological Activity Evaluation, Molecular Docking, and Molecular Dynamics., PMID:40191330
Inhibition of mitoNEET ameliorates traumatic brain injury-induced ferroptosis and cognitive dysfunction by stabilizing dihydroorotate dehydrogenase., PMID:40189124
Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer., PMID:40185704
Akt mitigates ER stress-instigated cardiac dysfunction via regulation of ferroptosis and mitochondrial integrity in a DHODH-dependent manner., PMID:40164331
Identification of Bioactive Metabolites of Capirona macrophylla by Metabolomic Analysis, Molecular Docking, and In Vitro Antiparasitic Assays., PMID:40137122
Unsaturated fatty acid-doped liposomes deliver piperine to deactivate defensive mechanism for ferroptosis in cancer therapy., PMID:40122242
DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response., PMID:40119669
Ubiquinol-mediated suppression of mitochondria-associated ferroptosis is a targetable function of lactate dehydrogenase B in cancer., PMID:40090955
Targeting YBX1-m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma., PMID:40088428
Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatment., PMID:40066333
Targeting both the enzymatic and non-enzymatic functions of DHODH as a therapeutic vulnerability in c-Myc-driven cancer., PMID:39977268
Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL., PMID:39975156
Crystal structure of dihydroorotate dehydrogenase from Helicobacter pylori with bound flavin mononucleotide., PMID:39960828
Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models., PMID:39900124
Quinoline and quinolone carboxamides: A review of anticancer activity with detailed structure-activity relationship analysis., PMID:39873887
Invasive lobular carcinoma integrated multi-omics analysis reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistance., PMID:39868332
Exploring the antifungal potential of Cannabis sativa-derived stilbenoids and cannabinoids against novel targets through in silico protein interaction profiling., PMID:39834844
Identification of Drug-Targetable Genes for Eczema and Dermatitis Using Integrated Genomic and Proteomic Approaches., PMID:39786806
Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium., PMID:39761766
Ginsenoside Rd alleviates early brain injury by inhibiting ferroptosis through cGAS/STING/DHODH pathway after subarachnoid hemorrhage., PMID:39746578
Combination decoction of Astragalus mongholicus and Salvia miltiorrhiza mitigates pressure-overload cardiac dysfunction by inhibiting multiple ferroptosis pathways., PMID:39737072
Exploring the Venom Gland Transcriptome of Bothrops asper and Bothrops jararaca: De Novo Assembly and Analysis of Novel Toxic Proteins., PMID:39728769
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors., PMID:39698280
Methylophiopogonanone A Inhibits Ferroptosis in H9c2 Cells: An Experimental and Molecular Simulation Study., PMID:39683922
Lipocalin-2 silencing alleviates sepsis-induced liver injury through inhibition of ferroptosis., PMID:39662594
Ferroptosis: when metabolism meets cell death., PMID:39661331
PACS2/CPT1A/DHODH signaling promotes cardiomyocyte ferroptosis in diabetic cardiomyopathy., PMID:39633391
More Pieces of the Puzzle: Transient State Analysis of Dihydroorotate Dehydrogenase B from Lactoccocus lactis., PMID:39620420
Virtual screening and molecular dynamics studies of novel small molecules targeting Schistosoma mansoni DHODH: identification of potential inhibitors., PMID:39620199
Molecular analysis of the 2022 mpox outbreak and antiviral activity of dihydroorotate dehydrogenase inhibitors against orthopoxviruses., PMID:39608644
Mechanisms of S-phase arrest and mitochondrial dysfunction in complex III by DHODH inhibitors in tumorigenic TNBC cells., PMID:39557682
To quest new targets of Plasmodium parasite and their potential inhibitors to combat antimalarial drug resistance., PMID:39493470
A mild skeletal phenotype with overlapping features of Miller syndrome and functional characterisation of two new variants of human dihydroorotate dehydrogenase., PMID:39430512
In vitro antiplasmodium and antitrypanosomal activities, β-haematin formation inhibition, molecular docking and DFT computational studies of quinoline-urea-benzothiazole hybrids., PMID:39397937
Development of a machine learning-based target-specific scoring function for structure-based binding affinity prediction for human dihydroorotate dehydrogenase inhibitors., PMID:39325045
Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity., PMID:39306285
Knockdown of SLC16A3 decreases extracellular lactate concentration in hepatocellular carcinoma, alleviates hypoxia and induces ferroptosis., PMID:39303526
Mitochondrial Dysfunction-Evoked DHODH Acetylation is Involved in Renal Cell Ferroptosis during Cisplatin-Induced Acute Kidney Injury., PMID:39303219
Bone marrow stromal cells enhance differentiation of acute myeloid leukemia induced by pyrimidine synthesis inhibitors., PMID:39279497
Engineering Biodegradable Hollow Silica/Iron Composite Nanozymes for Breast Tumor Treatment through Activation of the "Ferroptosis Storm"., PMID:39226614
BNIP3-mediated mitophagy attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting ferroptosis through P62-KEAP1-NRF2 pathway activation to maintain iron and redox homeostasis., PMID:39179868
For research use only. Not for human or drug use.
