Catalog No.
YHF87401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu20-Arg94
Predicted molecular weight
10.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01523
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HD5(20-94), DEF5, Defensin-5, DEFA5, Defensin, alpha 5
Identification and Validation of Key Genes Involved in the Coupling of Mitochondria-Associated Endoplasmic Reticulum Membrane in Hemorrhoidal Disease., PMID:40469970
Large-scale Plasma Proteomic Profiling Unveils Novel Diagnostic Biomarkers and Pathways for Alzheimer's Disease., PMID:40166037
Activating Thermoplastic Polyurethane Surfaces with Poly(ethylene glycol)-Based Recombinant Human α-Defensin 5 Monolayers for Antibiofilm Activity., PMID:39977277
Shigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11., PMID:39901059
Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues., PMID:39883179
Regulation of Paneth cell-specific genes in COVID-19 patients and SARS-CoV-2-infected mice by quantification of mRNA from exfoliated cells in stool samples., PMID:39738327
Intestinal Epithelial PTPN2 Limits Pathobiont Colonization by Immune-Directed Antimicrobial Responses., PMID:39386684
Establishment of an in-vitro inflammatory bowel disease model using immunological differentiation of Caco-2 cells., PMID:39329151
Alterations in the plasma proteome persist ten months after recovery from mild to moderate SARS-CoV-2 infection., PMID:39324144
Anti-DEFA5 Monoclonal Antibody Clones 1A8 and 4F5 Immunoreactive Bioassay for Diagnosing Inflammatory Bowel Disease., PMID:39257990
Innate Immunity Activation in Newly Diagnosed Ileocolonic Crohn's Disease: A Cohort Study., PMID:38319717
Regulation of Chloride Channels by Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Induced α-Defensin 5., PMID:38171775
Application of enzyme-linked immunosorbent assay to detect antimicrobial peptides in human intestinal lumen., PMID:38081407
FOXO inhibition rescues α-defensin expression in human intestinal organoids., PMID:37956278
The Function and Modification of Human Defensin 5., PMID:37861034
Ubiquitous Colonic Ileal Metaplasia Consistent with the Diagnosis of Crohn's Colitis among Indeterminate Colitis Cohorts., PMID:37854669
Human α-Defensin 51-9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet., PMID:37762180
Reduced DEFA5 Expression and STAT3 Activation Underlie the Submucosal Invasion of Early Gastric Cancers., PMID:37598668
Predicting Duodenal Cancer Risk in Patients with Familial Adenomatous Polyposis Using Machine Learning Model., PMID:37565794
Serotonin reuptake transporter deficiency promotes liver steatosis and impairs intestinal barrier function in obese mice fed a Western-style diet., PMID:37246491
Integrated multiple microarray studies by robust rank aggregation to identify immune-associated biomarkers in Crohn's disease based on three machine learning methods., PMID:36792688
3' untranslated region variants in DEFA5 gene associated with susceptibility to IgA nephropathy in the Chinese Han population., PMID:36632813
Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation., PMID:36341397
Electroacupuncture promoted intestinal defensins and rescued the dysbiotic cecal microbiota of high-fat diet-induced obese mice., PMID:36116529
Evaluation of the Binding Mechanism of Human Defensin 5 in a Bacterial Membrane: A Simulation Study., PMID:34830284
Protective Role of Spermidine in Colitis and Colon Carcinogenesis., PMID:34767785
Identification of diagnostic signatures in ulcerative colitis patients via bioinformatic analysis integrated with machine learning., PMID:34731452
Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation., PMID:34635074
The penetration of human defensin 5 (HD5) through bacterial outer membrane: simulation studies., PMID:34546425
Resveratrol Improves Growth Performance, Intestinal Morphology, and Microbiota Composition and Metabolism in Mice., PMID:34539617
Human α-defensin 5 suppressed colon cancer growth by targeting PI3K pathway., PMID:34487729
Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study., PMID:34105106
Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease., PMID:33690604
Nanodefensin-encased hydrogel with dual bactericidal and pro-regenerative functions for advanced wound therapy., PMID:33664853
Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin., PMID:33518681
Astaxanthin Alleviates Ochratoxin A-Induced Cecum Injury and Inflammation in Mice by Regulating the Diversity of Cecal Microbiota and TLR4/MyD88/NF-κB Signaling Pathway., PMID:33505592
The inhibitory effect of human DEFA5 in growth of gastric cancer by targeting BMI1., PMID:33503272
Defensin-driven viral evolution., PMID:33232373
Defensin 5 for prevention of SARS-CoV-2 invasion and Covid-19 disease., PMID:33017910
High level of defensin alpha 5 in intestine may explain the low incidence of diarrhoea in COVID-19 patients., PMID:32976188
Fat-Shaped Microbiota Affects Lipid Metabolism, Liver Steatosis, and Intestinal Homeostasis in Mice Fed a Low-Protein Diet., PMID:32579743
A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity., PMID:32503648
Human Intestinal Defensin 5 Inhibits SARS-CoV-2 Invasion by Cloaking ACE2., PMID:32437749
Gene Signatures of Early Response to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease., PMID:32397546
Absence of neurotensin attenuates intestinal dysbiosis and inflammation by maintaining Mmp7/α-defensin axis in diet-induced obese mice., PMID:32359121
An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease., PMID:32351509
Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy., PMID:32089753
An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease., PMID:32086815
Anticancer potential of human intestinal defensin 5 against 1, 2-dimethylhydrazine dihydrochloride induced colon cancer: A therapeutic approach., PMID:31981594
Alpha-defensin 5 differentially modulates adenovirus vaccine vectors from different serotypes in vivo., PMID:31841560
For research use only. Not for human or drug use.
