Catalog No.
YHF84301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp132
Predicted molecular weight
16.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q00975
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Brain calcium channel III, Voltage-gated calcium channel subunit alpha Cav2.2, CACNL1A5, CACH5, BIII, CACNA1B, Calcium channel, L type, alpha-1 polypeptide isoform 5, Voltage-dependent N-type calcium channel subunit alpha-1B
Gene expression profiling of extraocular muscles in primary inferior oblique overaction., PMID:40452936
Seven loci associated with schizophrenia and bipolar I disorder in selected southern African population groups., PMID:39999946
C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models., PMID:39656529
Peripheral CaV2.2 Channels in the Skin Regulate Prolonged Heat Hypersensitivity during Neuroinflammation., PMID:39433408
Cannabinol (CBN) Influences the Ion Channels and Synaptic-Related Genes in NSC-34 Cell Line: A Transcriptomic Study., PMID:39329756
Uncoupling the CRMP2-CaV2.2 Interaction Reduces Pain-Like Behavior in a Preclinical Joint-Pain Model., PMID:39233208
Interleukin-1α links peripheral CaV2.2 channel activation to rapid adaptive increases in heat sensitivity in skin., PMID:38643253
Whole transcriptome sequencing analyses of islets reveal ncRNA regulatory networks underlying impaired insulin secretion and increased β-cell mass in high fat diet-induced diabetes mellitus., PMID:38557554
CACNA1B protects naked mole-rat hippocampal neuron from apoptosis via altering the subcellular localization of Nrf2 after 60Co irradiation., PMID:38389270
An orally available Cav2.2 calcium channel inhibitor for the treatment of neuropathic pain., PMID:38157867
Electroacupuncture at GB20 improves cognitive ability and synaptic plasticity via the CaM-CaMKII-CREB signaling pathway following cerebral ischemia-reperfusion injury in rats., PMID:38126262
Functional implications of paralog genes in polyglutamine spinocerebellar ataxias., PMID:37845370
Meta-Analysis of Mechano-Sensitive Ion Channels in Human Hearts: Chamber- and Disease-Preferential mRNA Expression., PMID:37446137
A pilot pharmacogenetic study of calcium channel blocker treatment of bipolar mania., PMID:37270865
Cav2.2 Channels Sustain Vesicle Recruitment at a Mature Glutamatergic Synapse., PMID:37185239
Whole-Genome Sequencing Among Kazakhstani Children with Early-Onset Epilepsy Revealed New Gene Variants and Phenotypic Variability., PMID:37095367
N-Type Ca Channel in Epileptic Syndromes and Epilepsy: A Systematic Review of Its Genetic Variants., PMID:37047073
Effect of semaglutide and empagliflozin on cognitive function and hippocampal phosphoproteomic in obese mice., PMID:37007007
Nerve injury increases native Ca V 2.2 trafficking in dorsal root ganglion mechanoreceptors., PMID:36524581
Estimation of genetic parameters and single-step genome-wide association studies for milk urea nitrogen in Holstein cattle., PMID:36460511
Cav2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization., PMID:36137995
BaseScope™ Approach to Visualize Alternative Splice Variants in Tissue., PMID:35895265
High expression of N-type calcium channel indicates a favorable prognosis in gliomas., PMID:35777045
Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing., PMID:35773312
Generalised dystonic presentation of CACNA1B-associated dystonia and its response to Levodopa., PMID:35698023
N-type calcium channel v2.2 is a target of TCF21 in adrenocortical carcinomas., PMID:35603952
High-voltage long-duration pulsed radiofrequency attenuates neuropathic pain in CCI rats by inhibiting Cav2.2 in spinal dorsal horn and dorsal root ganglion., PMID:35341732
In Silico Analysis of Ion Channels and Their Correlation with Epithelial to Mesenchymal Transition in Breast Cancer., PMID:35326596
A Clinical and Integrated Genetic Study of Isolated and Combined Dystonia in Taiwan., PMID:35041927
Valproic acid promotes differentiation of adipose tissue-derived stem cells to neuronal cells selectively expressing functional N-type voltage-gated Ca2+ channels., PMID:34891042
Closed-state inactivation and pore-blocker modulation mechanisms of human CaV2.2., PMID:34731621
Heat But Not Mechanical Hypersensitivity Depends on Voltage-Gated CaV2.2 Calcium Channel Activity in Peripheral Axon Terminals Innervating Skin., PMID:34353899
The impact of gene-body H3K36me3 patterns on gene expression level changes in chronic myelogenous leukemia., PMID:34352296
Structure of human Cav2.2 channel blocked by the painkiller ziconotide., PMID:34234349
The Drosophila ortholog of the schizophrenia-associated CACNA1A and CACNA1B voltage-gated calcium channels regulate memory, sleep and circadian rhythms., PMID:34015490
Icariin ameliorates partial sciatic nerve ligation induced neuropathic pain in rats: an evidence of in silico and in vivo studies., PMID:33822115
TWIST1 preserves hematopoietic stem cell function via the CACNA1B/Ca2+/mitochondria axis., PMID:33619534
Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain., PMID:33459966
Reduced Graphene Oxides Modulate the Expression of Cell Receptors and Voltage-Dependent Ion Channel Genes of Glioblastoma Multiforme., PMID:33419226
CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways., PMID:33360835
CACNA1B facilitates breast cancer cell growth and migration by regulating cyclin D1 and EMT: the implication of CACNA1B in breast cancer., PMID:33100116
Expression and functions of N-type Cav2.2 and T-type Cav3.1 channels in rat vasopressin neurons under normotonic conditions., PMID:33059597
CACNA1B gene variants in adult-onset isolated focal dystonia., PMID:33051750
Probing Synaptic Signaling with Optogenetic Stimulation and Genetically Encoded Calcium Reporters., PMID:32865742
Modulation of intracellular calcium concentration by D2-like DA receptor agonists in non-peptidergic DRG neurons is mediated mainly by D4 receptor activation., PMID:32717335
Inhibition of Histone Methyltransferase EZH2 Suppresses Endometriotic Vesicle Development in a Rat Model of Endometriosis., PMID:32651901
Genetic associations between voltage-gated calcium channels and autism spectrum disorder: a systematic review., PMID:32571372
Knockdown of microglial Cav2.2 N-type voltage-dependent Ca2+ channel ameliorates behavioral deficits in a mouse model of Parkinson's disease., PMID:32484574
Constitutive activity of dopamine receptor type 1 (D1R) increases CaV2.2 currents in PFC neurons., PMID:32259196
Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function., PMID:32213287
For research use only. Not for human or drug use.
