Catalog No.
YHF83101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro38-Leu343
Predicted molecular weight
36.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q00653
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lymphocyte translocation chromosome 10 protein, NFKB2, LYT10, H2TF1, Nuclear factor NF-kappa-B p100 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, DNA-binding factor KBF2, Oncogene Lyt-10, Lyt10
NF-κB pathway variants in Iranian patients with inborn errors of immunity., PMID:40320674
TRAIL induces cytokine production via the NFkB2 pathway promoting neutrophil chemotaxis and neutrophil-mediated immune-suppression in triple negative breast cancer cells., PMID:40187604
Case report: novel NFKB2 variant associated with pediatric eosinophilic granulomatosis with polyangiitis (EGPA) in the COVID-19 pandemic., PMID:40165201
Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation., PMID:39607428
Effects of high-pressure-processed rice intake during interval walking training on glycemic control and NFKB2 gene methylation in hyperglycemic older people., PMID:39589533
A Novel Heterozygous NFKB2 Variant in a Multiplex Family with Common Variable Immune Deficiency and Autoantibodies Against Type I IFNs., PMID:39579251
Type-Specific Impacts of Protein Defects in Pathogenic NFKB2 Variants: Novel Clinical Findings From 138 Patients., PMID:39447838
Biophysical characterization of RelA-p52 NF-κB dimer-A link between the canonical and the non-canonical NF-κB pathway., PMID:39412374
Intrinsic functional defects in B cells of patients with NFKB2 mutations., PMID:39405181
Unconventional p65/p52 NF-κB module regulates key tumor microenvironment-related genes in breast tumor-associated macrophages (TAMs)., PMID:39278618
Inherited human RelB deficiency impairs innate and adaptive immunity to infection., PMID:39231201
Disseminated tuberculosis is associated with impaired T cell immunity mediated by non-canonical NF-κB pathway., PMID:39032519
Clinical, Immunological, and Genetic Features in Patients with NFKB1 and NFKB2 Mutations: a Systematic Review., PMID:38990428
A case of novel NFKB2 variant with hypertensive emergency and nephrotic syndrome leading to CKD 5D., PMID:38587560
Generalized pustular psoriasis that developed in a patient with an NFKB2 variant., PMID:38117957
TRIM55 promotes noncanonical NF-κB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing., PMID:37816088
Deficient anterior pituitary with common variable immune deficiency (DAVID syndrome): a new case and literature reports., PMID:37322808
Novel NFKB2 Pathogenic Variants in Two Unrelated Patients with Common Variable Immunodeficiency., PMID:37191755
Analysis of NFKB1 and NFKB2 gene expression in the blood of patients with sudden sensorineural hearing loss., PMID:36773447
NFKB2 haploinsufficiency identified via screening for IFN-α2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications., PMID:36509151
Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa., PMID:35916405
TiO2 nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2., PMID:34799167
Disseminated Coccidioidomycosis as the First Presentation of a C-Terminal NFKB2 Pathogenic Variant: A Case Report and Review of the Literature., PMID:34609106
An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module., PMID:34155144
NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration., PMID:34023356
Trim14 promotes osteoclastogenesis and noncanonical NF-κB activation by targeting p100/p52 in chronic periodontitis., PMID:33901321
More severe than CVID: Combined immunodeficiency due to a novel NFKB2 mutation., PMID:33369776
Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility., PMID:33107914
BET inhibitor suppresses melanoma progression via the noncanonical NF-κB/SPP1 pathway., PMID:33052224
Programmed death ligand-1 (PD-L1) expression in meningioma; prognostic significance and its association with hypoxia and NFKB2 expression., PMID:32839486
A Nonsense N -Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency., PMID:32813180
TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy., PMID:32591397
Circulating Myeloid-derived Suppressor Cells Facilitate Invasion of Thyroid Cancer Cells by Repressing miR-486-3p., PMID:32492708
NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium., PMID:32152480
NFKB2 gene expression in patients with peptic ulcer diseases and gastric cancer., PMID:32056043
A 32-year-old female with relapsing polychondritis and common variable immunodeficiency due to a monogenic mutation in NFKB2., PMID:31873736
NFKB2 regulates human Tfh and Tfr pool formation and germinal center potential., PMID:31751612
Expression Of Intracellular Components of the NF-κB Alternative Pathway (NF-κB2, RelB, NIK and Bcl3) is Associated With Clinical Outcome of NSCLC Patients., PMID:31586084
Role of NF-kappaB2-p100 in regulatory T cell homeostasis and activation., PMID:31554891
Familial hypogammaglobulinemia with high RTE and naïve T lymphocytes., PMID:31468084
ECCR1 and NFKB2 Polymorphisms as Potential Biomarkers of Non-small Cell Lung Cancer in a Polish Population., PMID:31177178
Compounds of PAH mixtures dependent interaction between multiple signaling pathways in granulosa tumour cells., PMID:30980910
Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency., PMID:30953794
Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2., PMID:30941118
Fetal lung C4BPA induces p100 processing in human placenta., PMID:30940885
Fatal Enteroviral Encephalitis in a Patient with Common Variable Immunodeficiency Harbouring a Novel Mutation in NFKB2., PMID:30927119
The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate., PMID:30716099
A novel NFKB2 mutation in a Chinese patient with DAVID syndrome., PMID:30599236
Early B cell developmental impairment with progressive B cell deficiency in NFKB2 mutated CVID disease without autoimmunity., PMID:30500415
Fibroblast growth factor-2 inhibits CD40-mediated periodontal inflammation., PMID:30370560
For research use only. Not for human or drug use.
