Catalog No.
YHF75501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp220-Ser425
Predicted molecular weight
25.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P84022
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mad3, JV15-2, Mothers against decapentaplegic homolog 3, SMAD family member 3, Smad3, SMAD3, MADH3, hMAD-3, SMAD 3, MAD homolog 3, hSMAD3, Mothers against DPP homolog 3
Regulation of epithelial-mesenchymal plasticity in pancreatic ductal adenocarcinoma: Role of key molecules in tumor differentiation and therapy., PMID:40499272
miR-320-3p regulates apelin and TGF-β/SMAD3 signaling in hypobaric hypoxia exposed rats to induce skeletal muscle atrophy., PMID:40498412
FOXO1 contributes to cigarette smoke condensate-induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway., PMID:40498253
Effect of miR-29a-3p on renal interstitial fibrosis in diabetic kidney disease through FOXP1-mediated TGF-β1/Smad3 signaling pathway., PMID:40497041
Ligand-specific regulation of a binary enhancer code dictating cellular senescence., PMID:40493192
Amygdalin Alleviates Airway Inflammation and Remodeling in Asthma Mice: Involvement of TGF-β1/Smads Signaling Pathway., PMID:40485525
HNRNPC promotes keloid progression via modulating the stability of m6A-modified WDR77 mRNA and expression of TGF-β and SMAD3., PMID:40484365
Involvement of ADAM17-dependent MUC1-CT activation in TGF-β-induced EZH2 expression in human lung fibroblasts and in ovalbumin-induced airway fibrosis in mice., PMID:40484037
Design and discovery of novel cyclic peptides as TSP1-CD36 interaction inhibitors for intestinal fibrosis treatment., PMID:40483936
Investigation of HO-1 Regulation of Liver Fibrosis Related to Nonalcoholic Fatty Liver Disease Through the SIRT1/TGF-ß/Smad3 Pathway., PMID:40474887
Growth hormone combined with estrogen improves intrauterine adhesion fibrosis by downregulating endometrial microbial citraconic acid to target β-catenin protein., PMID:40470939
A Super-Enhancer-Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration-Resistant Prostate Cancer., PMID:40470696
Probing the binding hypothesis of Smad3 modulators by molecular dynamic simulations for Atherosclerosis Cardiovascular Disease (ASCVD)., PMID:40465783
CHIP mediates glucagon action on hepatic glucose production via regulating Smad3 ubiquitination., PMID:40462730
Plasma exosome proteomics reveals upregulation of CILP-1 in concave side of paraspinal muscle in adolescent idiopathic scoliosis., PMID:40461962
[Effects of total extract of Anthriscus sylvestris on immune inflammation and thrombosis in rats with pulmonary arterial hypertension based on TGF-β1/Smad3 signaling pathway]., PMID:40461203
Allicin induced AMPK signaling attenuated Smad3 pathway mediated lung fibrosis., PMID:40447631
Growth differentiation factor-8 promotes human extravillous trophoblast cell invasion by increasing ANGPTL4 expression., PMID:40435667
Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1α Inhibition in a Mouse Model., PMID:40433398
MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3., PMID:40425777
3,4-Dimethoxycinnamic acid from coffee silverskin biowaste ameliorates bleomycin-induced pulmonary fibrosis via modulating caveolin-1-dependent activation of NF-κB, TGF-β1/Smad3, and ERK1/2 signaling pathways., PMID:40425068
SMAD2 S-palmitoylation promotes its linker region phosphorylation and TH17 cell differentiation in a mouse model of multiple sclerosis., PMID:40424363
TGF-β Enhances Doxorubicin Resistance and Anchorage-Independent Growth in Cancer Cells by Inducing ALDH1A1 Expression., PMID:40414259
Targeting interferon regulatory factor 7 alleviates renal fibrosis by inhibiting macrophage-to-myofibroblast transition., PMID:40412608
LncRNA SNHG12 promotes EMT and metastasis of colorectal cancer via regulating TGF-β/Smad2/3 signaling pathway., PMID:40412277
Identification of regulatory cell death-related genes during MASH progression using bioinformatics analysis and machine learning strategies., PMID:40406118
Autophagic degradation of SQSTM1 enables fibroblast activation to accelerate wound healing., PMID:40400126
Functional metabolomics revealed pyroglutamic acid may play a key role in idiopathic pulmonary fibrosis., PMID:40398246
Naringin Alleviates Digoxin-induced Nephrotoxicity via Regulating Nrf2/HO-1 and PI3K/ AKT/TGF-β Cascades in Rats' Renal Tissues., PMID:40396295
Taraxacum mongolicum total triterpenoids and taraxasterol ameliorate benign prostatic hyperplasia by inhibiting androgen levels, inflammatory responses, and epithelial-mesenchymal transition via the TGFβ1/Smad signalling pathway., PMID:40393639
Mesenchymal stem cell exosomes regulate TGFβ/Smad3 by decreasing the METTL3-NEAT1 axis to inhibit scar progression after breast surgery., PMID:40392368
Suppressing MASH fibrotic progression by blocking succinate-GPR91 signaling in hepatic stellate cells., PMID:40392081
The Genetic Association between CDKN1A and Heart Failure: Genome-Wide Exploration of m 6A-SNPs and Mendelian Randomization., PMID:40383946
Identification of a Distal Enhancer That Regulates TGF-β-Induced SNAI1 Expression., PMID:40364580
Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degeneration., PMID:40356987
Cellular senescence promotes macrophage-to-myofibroblast transition in chronic ischemic renal disease., PMID:40348745
Lacking TRPA1 cation channel impairs primary closure of a stromal incision injury in a mouse cornea., PMID:40348381
MRI-based machine learning reveals proteasome subunit PSMB8-mediated malignant glioma phenotypes through activating TGFBR1/2-SMAD2/3 axis., PMID:40335825
Aldose reductase -mediated HUR ubiquitination enhances exosome release and hepatic fibrosis via ROS/PI3K/AKT pathway., PMID:40334999
From Skeletal Muscle to Myocardium: Molecular Mechanisms of Exercise-Induced Irisin Regulation of Cardiac Fibrosis., PMID:40332022
[Construction of mouse podocyte clone-5 cell lines with Smad3 knockout by CRISPR/Cas9]., PMID:40328723
[Smad3 signaling pathway promotes silica-induced epithelial-mesenchymal transition]., PMID:40328617
Twenty-five years of WWOX insight in cancer: a treasure trove of knowledge., PMID:40327201
Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF-β/Smad2/3 Signaling in Mice., PMID:40323694
FKBP10 Silencing Alleviates Gluteal Muscle Contracture by Inhibiting Fibrosis and Restoring Autophagy via HSP47/SMAD3 Pathway Inactivation., PMID:40316212
LncRNA PVT1 activated by TGF-β1/Smad3 facilitates proliferation and metastasis of hepatocellular carcinoma via upregulating Smad6 and NRG1., PMID:40312711
Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics., PMID:40307879
Nanoparticle-mediated dual targeting of stromal and immune components to overcome fibrotic and immunosuppressive barriers in hepatocellular carcinoma., PMID:40306574
Roles of Transmembrane Protein 119 in the Effects of Transforming Growth Factor-β on Mouse Bone Cells., PMID:40300647
The Role of MCPIP1 in Macrophage Polarization and Cardiac Function Post-Myocardial Infarction., PMID:40285621
For research use only. Not for human or drug use.
