Catalog No.
YHF56301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Val217
Predicted molecular weight
27.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P62993
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein Ash, GRB2, Growth factor receptor-bound protein 2, SH2/SH3 adapter GRB2, ASH, Adapter protein GRB2
Identification of Grb2 protein as a potential mediator of macrophage activation in acute pancreatitis based on bioinformatics and experimental verification., PMID:40491924
Allosteric modulation of Grb2 drives ligand-dependent signal responses., PMID:40410909
GRB2 Promotes Malignant Behaviors of Breast Cancer by Modulating the Global Expression and Alternative Splicing Profiles in SK-BR-3 Cells Through Binding mRNA., PMID:40384436
Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development., PMID:40327534
GRB2 promotes brain metastasis in HER2-positive breast cancer by regulating the Ras/MAPK pathway., PMID:40289214
Laminar organization of molecular complexes in a clathrin coat revealed by nanoscale protein colocalization., PMID:40273906
Novel potent heterocyclic Grb2-SH2 domain antagonists as potential anti-proliferative agents., PMID:40157294
GRB2 regulation of essential signaling pathways in the endometrium is critical for implantation and decidualization., PMID:40038241
IL-22-mediated microRNA-124-3p/GRB2 axis regulates hyperproliferation and inflammatory response of keratinocytes in psoriasis., PMID:39792268
Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction., PMID:39723820
DDR1 promotes metastasis of cervical cancer and downstream phosphorylation signal via binding GRB2., PMID:39567474
Generating and validating renewable affimer protein binding reagents targeting SH2 domains., PMID:39550397
The activation of SYNJ2/GRB2 axis accelerates the malignant metastasis and angiogenesis of gastric cancer cells., PMID:39521152
The role of GRB2 in diabetes, diabetes complications and related disorders., PMID:39478285
Association of the rs9896052 Polymorphism Upstream of GRB2 with Proliferative Diabetic Retinopathy in Patients with Less than 10 Years of Diabetes., PMID:39408563
Insulin receptor substrate 1 is a novel member of EGFR signaling in pancreatic cells., PMID:39326351
Spatial and signaling overlap of growth factor receptor systems at clathrin-coated sites., PMID:39292879
DUS4L suppresses invasion and metastasis in LUAD via modulation of PI3K/AKT and ERK/MAPK signaling through GRB2., PMID:39216120
Targeting Grb2 SH3 Domains with Affimer Proteins Provides Novel Insights into Ras Signalling Modulation., PMID:39199427
Grb2 Y160F mutant mimics the wild-type monomeric state dynamics and the monomer-dimer equilibrium., PMID:39182877
Ginsenoside Rg3 Restores Mitochondrial Cardiolipin Homeostasis via GRB2 to Prevent Parkinson's Disease., PMID:39159293
Porcine deltacoronavirus nucleocapsid protein interacts with the Grb2 through its proline-rich motifs to induce activation of the Raf-MEK-ERK signal pathway and promote virus replication., PMID:39136113
TGF-β-induced lncRNA TBUR1 promotes EMT and metastasis in lung adenocarcinoma via hnRNPC-mediated GRB2 mRNA stabilization., PMID:39102940
Structural basis of binding the unique N-terminal domain of microtubule-associated protein 2c to proteins regulating kinases of signaling pathways., PMID:39002671
Regulation of RHOV signaling by interaction with SH3 domain-containing adaptor proteins and phosphorylation by PKA., PMID:38959529
Gga-miR-200a-3p suppresses avian reovirus-induced apoptosis and viral replication via targeting GRB2., PMID:38909417
ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner., PMID:38862918
CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche., PMID:38805286
GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer., PMID:38459011
The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain., PMID:38432639
GRB2 is a BECN1 interacting protein that regulates autophagy., PMID:38182563
Unveiling Metastable Ensembles of GRB2 and the Relevance of Interdomain Communication during Folding., PMID:37824286
Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB - GRB2/ERK/RUNX2 pathway., PMID:37798786
Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes., PMID:37777158
GRB2 serves as a viable target against skin fibrosis in systemic sclerosis by regulating endothelial cell apoptosis., PMID:37661474
RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma., PMID:37626338
FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development., PMID:37421147
GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production., PMID:36864087
High expression of GRB2 associated binding protein 3 mRNA predicts positive prognosis in melanoma., PMID:36545920
Exploring the effect of tethered domains on the folding of Grb2 protein., PMID:36265650
Anti-c-MET Fab-Grb2-Gab1 Fusion Protein-Mediated Interference of c-MET Signaling Pathway Induces Methuosis in Tumor Cells., PMID:36233320
The possible correlation between serum GRB2 levels and carotid atherosclerosis in patients with type 2 diabetes mellitus., PMID:36176460
Evaluation of the relationship between miR-1271 and GRB2 gene in endometriosis., PMID:35970002
A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions., PMID:35858593
A common IL-4 receptor variant promotes asthma severity via a Treg cell GRB2-IL-6-Notch4 circuit., PMID:35841382
The Role of the LINC01234/miR-433-3p/GRB2 ceRNA Network in NSCLC Cell Malignant Proliferation., PMID:35747966
The structural basis of BCR-ABL recruitment of GRB2 in chronic myelogenous leukemia., PMID:35651316
Synergistic effect of growth factor receptor-bound protein 2/epidermal growth factor receptor dual-targeting peptide inhibitor and salinomycin on osteosarcoma., PMID:35645100
TGF-β1/SH2B3 axis regulates anoikis resistance and EMT of lung cancer cells by modulating JAK2/STAT3 and SHP2/Grb2 signaling pathways., PMID:35589677
Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation., PMID:35574218
For research use only. Not for human or drug use.
