Catalog No.
YHF37801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr271
Predicted molecular weight
32.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P60842
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Eukaryotic initiation factor 4A-I, eIF4A-I, eIF-4A-I, EIF4A, EIF4A1, DDX2A, ATP-dependent RNA helicase eIF4A-1
BLF1 Affects ATP Hydrolysis Catalyzed by Native and Mutated eIF4A1 and eIF4A2 Proteins., PMID:40423315
Effect and mechanism of the miR-1284/EIF4A1 axis on the cGAS-STING pathway under radiotherapy., PMID:40386253
Comparative analysis of translatomics and transcriptomics in the longissimus dorsi muscle of Luchuan and Duroc pigs., PMID:40100799
Targeting YBX1-m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma., PMID:40088428
The DEAD-box helicase eIF4A1/2 acts as RNA chaperone during mitotic exit enabling chromatin decondensation., PMID:40069174
RNF10 and RIOK3 facilitate 40S ribosomal subunit degradation upon 60S biogenesis disruption or amino acid starvation., PMID:40022732
Targeting PGE2 mediated senescent neuron improves tumour therapy., PMID:39963753
eIF4A1 exacerbates myocardial ischemia-reperfusion injury in mice by promoting nuclear translocation of transgelin/p53., PMID:39856433
Correction: Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E., PMID:39710704
Critical and differential roles of eIF4A1 and eIF4A2 in B-cell development and function., PMID:39516355
Exploring the Regulatory Interaction of Differentially Expressed Proteins in Cleft Palate Induced by Retinoic Acid., PMID:39473103
CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice., PMID:39349455
Putting a Kink in HIV-1 Particle Infectivity: Rocaglamide Inhibits HIV-1 Replication by Altering Gag-Genomic RNA Interaction., PMID:39339982
DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs., PMID:39223140
Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice., PMID:39179537
Anti-tumor effects of the eIF4A inhibitor didesmethylrocaglamide and its derivatives in human and canine osteosarcomas., PMID:39164287
Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis., PMID:39117283
Curcumin Inhibits the Development of Pancreatic Cancer by Targeting the circ_0079440/miR-522-3p/EIF4A1 Pathway., PMID:39102088
Pharmacologic Inhibition of EIF4A Blocks NRF2 Synthesis to Prevent Osteosarcoma Metastasis., PMID:39078310
Anti-tumor Effects of the eIF4A Inhibitor Didesmethylrocaglamide and Its Derivatives in Human and Canine Osteosarcomas., PMID:38947012
Protein interactome analysis of ATP1B1 in alveolar epithelial cells using Co-Immunoprecipitation mass spectrometry and parallel reaction monitoring assay., PMID:38912441
Protein translation rate determines neocortical neuron fate., PMID:38849354
eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition., PMID:38773334
mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells., PMID:38738857
Identification and Verification of Endoplasmic Reticulum Stress-Related Genes as Novel Signatures for Osteoarthritis Diagnosis and Therapy: A Bioinformatics Analysis-Oriented Pilot Study., PMID:38734758
The m6A reader IGF2BP2 promotes esophageal cell carcinoma progression by enhancing EIF4A1 translation., PMID:38724996
The MYCN 5' UTR as a therapeutic target in neuroblastoma., PMID:38662542
Sporadic Amyotrophic Lateral Sclerosis Skeletal Muscle Transcriptome Analysis: A Comprehensive Examination of Differentially Expressed Genes., PMID:38540795
Bioinformatics integration reveals key genes associated with mitophagy in myocardial ischemia-reperfusion injury., PMID:38539069
The NP protein of Newcastle disease virus dictates its oncolytic activity by regulating viral mRNA translation efficiency., PMID:38377149
Comparative Analysis of Transcriptome Profiles in Patients with Thromboangiitis Obliterans., PMID:38275601
Computational inference of eIF4F complex function and structure in human cancers., PMID:38266053
Eukaryotic translation initiation factor 4A1 in the pathogenesis and treatment of cancers., PMID:38028556
Architecture, domain organization, and functional signatures of trypanosomatid keIF4A1s and Plasmodium peIF4A1s suggest conserved functions., PMID:38018538
RNA helicase EIF4A1-mediated translation is essential for the GC response., PMID:38011999
IGF2BP2 Drives Cell Cycle Progression in Triple-Negative Breast Cancer by Recruiting EIF4A1 to Promote the m6A-Modified CDK6 Translation Initiation Process., PMID:37983610
CircDLGAP4 overexpression ameliorates neuronal injury in Parkinson's disease by binding to EIF4A3 and increasing HMGA2 expression., PMID:37822284
Stem cells from human exfoliated deciduous teeth rejuvenate the liver in naturally aged mice by improving ribosomal and mitochondrial proteins., PMID:37815776
The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs., PMID:37768948
Computational inference of eIF4F complex function and structure in human cancers., PMID:37609226
Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates., PMID:37291191
5'-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I., PMID:36973570
Exploring the targeting spectrum of rocaglates among eIF4A homologs., PMID:36882295
Identification and Analysis of Hub Genes and Immune Cells Associated with the Formation of Acute Aortic Dissection., PMID:36818541
eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma., PMID:36768380
eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation., PMID:36727461
IFITM proteins assist cellular uptake of diverse linked chemotypes., PMID:36480603
Splicing factor SRSF3 represses translation of p21cip1/waf1 mRNA., PMID:36344491
Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules., PMID:36151083
Novel eIF4A1 inhibitors with anti-tumor activity in lymphoma., PMID:36058921
For research use only. Not for human or drug use.
