Catalog No.
YHF19601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu46-Thr457
Predicted molecular weight
48.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P56817
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BACE1, Memapsin-2, KIAA1149, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, BACE, Beta-site APP cleaving enzyme 1, Beta-secretase 1, Aspartyl protease 2, ASP2, Membrane-associated aspartic protease 2
BACE1 Inhibition Protects Against Type 2 Diabetes Mellitus by Restoring Insulin Receptor in Mice., PMID:40507910
Synaptic Vesicle Glycoprotein 2A Slows down Amyloidogenic Processing of Amyloid Precursor Protein via Regulating Its Intracellular Trafficking., PMID:40506382
Proposed Therapeutic Strategy to Combat Alzheimer's Disease by Targeting Beta and Gamma Secretases., PMID:40491367
A Novel Aβ B-cell epitope Vaccine, Aβ1-10 with carrier protein OVA and KLH reduce Aβ-induced neuroinflammation mediated neuropathology in mouse model of Alzheimer's disease., PMID:40484150
Exploration of Asparagus racemosus Willd for Alzheimer's Disease Through Integrated Metabolomics and Network Pharmacology Analyses Targeting BACE1 Protein., PMID:40483633
Soluble VCAM-1 may serve as a pharmacodynamic CSF marker to monitor BACE2 activity in non-human primates., PMID:40480341
Evaluating computational and experimental approaches in early-stage Alzheimer's drug discovery: a systematic review., PMID:40478444
Probing new 3-hydrazinyl indole phenacetamide derivatives as multitarget anti-Alzheimer: Synthesis, in vivo, in vitro, and in silico studies., PMID:40449120
Synthesis of substrate peptides incorporating non-natural amino acids and screening study using BACE1., PMID:40447163
Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Amyloid Precursor Protein Processing in Neuronal Cell Lines., PMID:40442550
Molecular mechanism of phosphorylation-mediated impacts on the conformation dynamics of ligand-bound BACE1 probed by Gaussian accelerated molecular dynamics., PMID:40439100
Targeted Neuroprotection in Sporadic Alzheimer's Disease: UPLC-ESI-MS/MS Profiling and Bilosome-Mediated Delivery of Crateva magna and Its Endophytic Fungal Extracts., PMID:40420219
Defective autophagy in a fibroin secretion-deficient silkworm mutant., PMID:40413758
Disruption of BAG3-mediated BACE1 stabilization alleviates neuropathology and memory deficits in a mouse model of Alzheimer's disease., PMID:40408490
Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease., PMID:40399225
Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice., PMID:40394225
The Quasi-Bound State as a Predictor of Relative Binding Free Energy., PMID:40392679
The interaction between neurotransmitter receptor activity and amyloid-β pathology in Alzheimer's disease., PMID:40388923
Repurposing pharmaceuticals for Alzheimer's treatment via adjusting the lactoferrin interacting proteins., PMID:40379164
In silico analysis of Chlorophytum borivilianum phytocompounds as a multi-targeted directed ligand (MTDL) against type 2 diabetes mellitus-induced Alzheimer's disease., PMID:40376790
Harnessing computational tools for drug discovery: An integrated computational approach to identify potential BACE-1 inhibitors., PMID:40373679
Ergothioneine Suppresses Amyloid β-Induced Tau Phosphorylation and Cytotoxicity by Inactivating Glycogen Synthase Kinase-3β in Cultured Neurons., PMID:40370244
Synthesis and Biological Evaluation of Novel Ramalin Derivatives as Multi-Target Agents for Alzheimer's Disease., PMID:40363835
Alzheimer's Is a Multiform Disease of Sustained Neuronal Integrated Stress Response Driven by the C99 Fragment Generated Independently of AβPP; Proteolytic Production of Aβ Is Suppressed in AD-Affected Neurons: Evolution of a Theory., PMID:40362488
Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine., PMID:40361183
Intranasal Delivery of BACE1 siRNA and Berberine via Engineered Stem Cell Exosomes for the Treatment of Alzheimer's Disease., PMID:40351705
Evaluation of the Neurotherapeutic Effect of Quercetin on Neuronal miR-124 and β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) in an Experimental Alzheimer's Disease Model., PMID:40341631
Key Chemotypes for the Rational Design of Dual AChE/BACE-1 Inhibitors., PMID:40329722
Empagliflozin and memantine combination ameliorates cognitive impairment in scopolamine + heavy metal mixture-induced Alzheimer's disease in rats: role of AMPK/mTOR, BDNF, BACE-1, neuroinflammation, and oxidative stress., PMID:40325262
Investigating the effects of 40 Hz sound stimulation on Alzheimer's disease pathways: Modulation of amyloid-β42 secretion, tau phosphorylation, phagocytosis, and autophagy., PMID:40320777
PINK1-dependent NFKB signaling contributes to amyloid pathology in Alzheimer disease., PMID:40320714
Neuroprotective effect of Licochalcone A against aluminum chloride-induced neurotoxicity by reducing Aβ accumulation, oxidative stress and inflammatory reaction., PMID:40311879
ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition., PMID:40301465
Identification of novel ligands against GSK-3β: Molecular docking, ADMET filtering, MD simulations, MM-GBSA studies, and DFT analysis., PMID:40300214
Brain-derived neurotrophic factor but not beta-secretase 1, vascular endothelial growth factor, glial fibrillary acidic protein and interleukin-1β correlate with cognitive impairment in adult persons with epilepsy: a cross-sectional single-center study from India., PMID:40291844
Trelagliptin Ameliorates Memory Decline in Diabetic Rats through the AMPK/AKT/GSK-3β Pathway in the Cerebral Cortex., PMID:40290996
Multi-Target Inhibitor of ZJQ- 3 F Against AChE/BACE1/GSK3β Targets Improves the Cognitive Impairment of APP/PS1/Tau Triple-Transgenic Mouse Models of Alzheimer's Disease., PMID:40285940
Blockage of CCL3 with neutralizing antibody reduces neuroinflammation and reverses Alzheimer disease phenotypes., PMID:40268067
APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ., PMID:40266681
Tripeptides inhibit dual targets AChE and BACE-1: a computational study., PMID:40264872
Bacopa monnieri phytochemicals as promising BACE1 inhibitors for Alzheimer's disease therapy., PMID:40251199
Exploring the Potential of Dolutegravir in Alzheimer's Disease Treatment: Insights from Network Pharmacology and In Silico Docking Studies., PMID:40231534
Convolidine as potent BACE1 inhibitor for Alzheimer's disease; in-silico coupled with in-vitro assessment., PMID:40208466
Sex-specific effects of chronic alcohol consumption across the lifespan in the transgenic Alzheimer's Disease (TgF344-AD) rat model., PMID:40187669
Shedding new light on BACE1-mediated modulation of IL-6 signaling: Implications for neural activity and synaptic plasticity in mice., PMID:40184913
The endocannabinoid system offers a target for Alzheimer's disease treatment through inhibition of fatty acid amide hydrolase (FAAH)., PMID:40172080
Mettl3 regulates the pathogenesis of Alzheimer's disease via fine-tuning Lingo2., PMID:40169805
IL-17 A Exacerbated Neuroinflammatory and Neurodegenerative Biomarkers in Intranasal Amyloid-Beta Model of Alzheimer's Disease., PMID:40163129
Amyloidogenic and non-amyloidogenic pathways of amyloid precursor protein processing in oligodendrocytes., PMID:40154861
GALM Alleviates Aβ Pathology and Cognitive Deficit Through Increasing ADAM10 Maturation in a Mouse Model of Alzheimer's Disease., PMID:40128515
For research use only. Not for human or drug use.
