Catalog No.
YHF17201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr648-Thr1057
Predicted molecular weight
46.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P56524
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Histone deacetylase 4, HDAC4, HD4, KIAA0288
Identification of Genomic Structural Variations in Xinjiang Brown Cattle by Deep Sequencing and Their Association with Body Conformation Traits., PMID:40508044
Histone Acetylation Modifications and HDACs are Associated with Resilience or Susceptibility to Stress in a Rat Model of Major Depressive Disorder., PMID:40504297
Long-lasting metabolic impairment in the failing heart: epigenetic memories at play., PMID:40492343
A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics., PMID:40455993
HDAC4: an emerging target in diabetes mellitus and diabetic complications., PMID:40448151
Chondroprotective role of histone deacetylase 4 in early-stage of temporomandibular joint osteoarthritis in male rats., PMID:40446518
Effect of HDAC4 regulation of β-catenin signaling pathway on cardiac injury in spontaneously hypertensive rats and its mechanism., PMID:40439605
Elevated HDAC4 Expression Is Associated with Reduced T-Cell Inflamed Tumor Microenvironment Gene Signatures and Immune Checkpoint Inhibitor Effectiveness in Melanoma., PMID:40361444
Caspase-Dependent Cell Death and HDAC4 Translocation Following Microsecond Pulsed Electric Field (μsPEF) Exposure in MCF-7 Breast Cancer Cells., PMID:40357894
Synergistic HDAC4/8 Inhibition Sensitizes Osteosarcoma to Doxorubicin via pAKT/RUNX2 Pathway Modulation., PMID:40332124
AMPK regulates HIF-1α to induce pupal diapause in the cotton bollworm, Helicoverpa armigera., PMID:40329626
HBP-A Attenuates Knee Osteoarthritis Progression via MLK3/P38/HDAC4 Axis-Mediated Dual Protection of Articular Cartilage and Quadriceps., PMID:40318007
Social hierarchy modulates drug reinforcement and protein phosphorylation in the nucleus accumbens., PMID:40290427
HDAC4 suppresses porcine epidemic diarrhea virus infection through negatively regulating MEF2A-GLUT1/3 axis- mediated glucose uptake., PMID:40250106
miRNA-based regulation in growth plate cartilage: mechanisms, targets, and therapeutic potential., PMID:40225327
HDAC4 super-enhancer drives CEBPB-mediated TWIST2 transcription to promote chemoresistance in LUAD., PMID:40222483
Dysregulation of the circ-Hdac4/miR-30c/RBPJ axis in decidua impairs placental function in preeclampsia., PMID:40208437
Activation of SIK1 by phanginin A regulates skeletal muscle glucose uptake by phosphorylating HADC4/5/7 and enhancing GLUT4 expression and translocation., PMID:40192973
Glucocorticoids regulate the expression of Srsf1 through Hdac4/Foxc1 axis to induce apoptosis of osteoblasts., PMID:40186004
Leucine Supplementation Counteracts the Atrophic Effects of HDAC4 in Rat Skeletal Muscle Submitted to Hindlimb Immobilization., PMID:40183248
Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique., PMID:40171441
Investigating the Role and Regulatory Mechanisms of the Histone Deacetylase 4 Gene in Chondrocyte Differentiation Impairments Associated With Kashin-Beck Disease., PMID:40143630
HDAC4-AS1/CTCF Transcriptionally Represses HDAC4 Under Stress, Whereas HDAC4 Inhibits Stress-Induced Syncytiotrophoblast Cellular Pyroptosis by Deacetylating NLRP3 and GSDMD., PMID:40103178
Inhibition of HDAC4 in granulosa cells improves co-cultured porcine oocyte maturation in vitro independently of LH., PMID:40066659
Seneca Valley virus 3C protease cleaves HDAC4 to antagonize type I interferon signaling., PMID:39927774
SGK1-HDAC4-HMGB1 signaling pathway in the spinal cord dorsal horn participates in diabetic neuropathic pain., PMID:39921539
Scaffolding Activities of Pseudodeacetylase HDAC7., PMID:39908122
HDAC4 regulates apoptosis in Acan-CreERT2;HDAC4d /d mice with osteoarthritis by downregulating ATF4., PMID:39895575
Ginkgolide B regulates apoptosis, oxidative stress, and mitochondrial dysfunction in MPP+-induced SK-N-SH cells by targeting HDAC4/JNK pathway., PMID:39878815
P3 site-directed mutagenesis: An efficient method based on primer pairs with 3'-overhangs., PMID:39863101
HDAC4/5 Inhibitor, LMK-235 Improves Animal Voluntary Movement in MPTP-Induced Parkinson's Disease Model., PMID:39806528
The Chicken HDAC4 Promoter and Its Regulation by MYC and HIF1A., PMID:39766786
Transcriptional regulation of daily sleep amount by TCF4-HDAC4-CREB complex in mice., PMID:39745887
Histone deacetylases synergistically regulate juvenile hormone signaling in the yellow fever mosquito, Aedes aegypti., PMID:39742981
Aerobic plus resistance exercise attenuates skeletal muscle atrophy induced by dexamethasone through the HDAC4/FoxO3a pathway., PMID:39732306
Trichostatin A reverses rocuronium resistance in burn-injured rats., PMID:39729668
Pharmacogenetic and microRNA mechanisms of beta blocker use on bone., PMID:39673185
MD simulations for rational design of high-affinity HDAC4 inhibitors - Analysis of non-bonding interaction energies for building new compounds., PMID:39662718
Magnolol Inhibits High Fructose-Induced Podocyte Inflammation via Downregulation of TKFC/Sp1/HDAC4/Notch1 Activation., PMID:39598328
HDAC4 Inhibits NMDA Receptor-mediated Stimulation of Neurogranin Expression., PMID:39581920
Tasquinimod promotes the sensitivity of ovarian cancer cells to cisplatin by down-regulating the HDAC4/p21 pathway., PMID:39539173
CRISPR activation identifies a novel miR-2861 binding site that facilitates the osteogenesis of human mesenchymal stem cells., PMID:39506798
Loss of Hdac4 in osteoprogenitors impairs postnatal trabecular and cortical bone formation, resulting in a dwarfism and osteopenia phenotype in mice., PMID:39481602
Qingrexiaoji Recipe Regulates the Differentiation of M2 TAM via miR-29 in GC., PMID:39428821
The N-terminal fragment of histone deacetylase 4 (1-669aa) promotes chondrocyte apoptosis via the p53-dependent endoplasmic reticulum stress pathway., PMID:39428562
The pivotal role of histidine 976 in human histone deacetylase 4 for enzyme function and ligand recognition., PMID:39406110
PTGER4 signaling regulates class IIa HDAC function and SPINK4 mRNA levels in rectal epithelial cells., PMID:39396982
Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling., PMID:39394127
LMK235 ameliorates inflammation and fibrosis after myocardial infarction by inhibiting LSD1-related pathway., PMID:39379699
TRPC5-mediated NLRP3 inflammasome activation contributes to myocardial cell pyroptosis in chronic intermittent hypoxia rats., PMID:39377158
For research use only. Not for human or drug use.
